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The expert seminar on the cinema film Chang ‘an Chang ‘an was held in Beijing. Experts in the industry believe that it has filled the gap in the film with the theme of "Belt and Road".

  International Online Shaanxi News (Reporter Liu Honghua): On the afternoon of July 5th, an expert seminar on the movie Changan was held in Beijing. The conference focused on the characterization, artistic exploration, and the significance of promoting the "Belt and Road" and promoting international cooperation in film and television. The participating experts spoke highly of the film’s theme conception, artistic characteristics, actors’ performances, as well as multicultural expression, multi-time narrative and multi-country creative cooperation.

An expert seminar on the movie Chang ‘an Chang ‘an was held in Beijing.

  A strategically located building serves as a pulse for international cooperation in China film industry.

Huang Yichuan, member of the 14th Chinese People’s Political Consultative Conference and researcher of China Film Art Research Center, presided over the seminar.

  As the first China-Iranian cooperative film under the background of the initiative of jointly building the Belt and Road, the film Chang ‘an Chang ‘an not only has profound story content and exquisite artistic expression, but also has far-reaching practical significance and historical connotation.

The cinema film "Chang 'an Chang 'an" expert viewing seminar was held in Beijing. Industry experts believe that it has filled the gap in the film with the theme of "Belt and Road" _fororder_ Speech by Abu Talifu, Political Counselor of Kazakh Embassy in China

Abu Talifu, Political Counselor of Kazakh Embassy in China, made a speech.

  Abu Talifu, Political Counselor of Kazakhstan Embassy in China, said that in recent years, the relationship between Kazakhstan and China has become closer and closer, and cooperation has deepened. The film Chang ‘an Chang ‘an is a love story between the people of Kazakhstan and China, which will further promote the exchanges between the two peoples and the cooperation between the two countries.

  Iranian Zadeh, Cultural Counselor of the Iranian Embassy in China, said that in terms of culture, both countries are ancient civilizations. Iranian filmmakers have participated in the screenwriting, producer, editing and composition of the film Chang ‘an Chang ‘an, hoping that the film will be released in Iran, which I believe will promote the better relations between Iran and China.

Zhang Ling, editor-in-chief of the Film Channel Program Center, spoke.

  Zhang Ling, editor-in-chief of the program center of the film channel, pointed out that as a film with the theme of "One Belt, One Road", "Chang ‘an Chang ‘an" is not superficial, but a small incision of self-salvation of a Kazakh woman, trying to deeply explore the hidden humanity behind the transnational marriage, and at the same time show the inside story of Chang ‘an in ancient and modern times and the culture and folk customs of different countries. The filming process of the film is also a promotion of the spirit of Silk Road.

Zhang Hong, member of the former party group and secretary of the Secretariat of the China Federation of Literary and Art Circles, secretary of the former party group of the China Film Association and vice chairman of the Association, spoke.

  Zhang Hong, a member of the former party group of the China Federation of Literary and Art Circles and secretary of the Secretariat, and the former party group secretary of the China Film Association and vice chairman of the Association, believes that the film Chang ‘an Chang ‘an fully reflects the concept of "five links" and fills the gap in the film with the theme of "Belt and Road"; At the same time, as a sincere work of cooperation among filmmakers from many countries, it is of international significance for the exchange and mutual learning of civilizations. In terms of artistic creation, the film’s characters are full in three dimensions, the story is true and credible, and the expression of love, affection and nostalgia is subtle and touching; In addition, music is also eye-catching, which plays a key role in setting off the film atmosphere and expressing the theme.

Qin Zhengui, Director of Publicity Department of the Communist Party of China Film Script Planning and Planning Center, spoke.

  Qin Zhengui, director of the Publicity Department of the Communist Party of China Screenplay Planning and Planning Center, said that the film "Chang ‘an Chang ‘an" really achieved the co-production of many countries and was the success of multi-party cooperation. The narrative rhythm of the film is smooth, and the actors perform brilliantly. At the same time, the traditional narrative and modern civilization are skillfully combined. It is expected that the film will meet audiences in Kazakhstan, Iran and other countries faster and achieve good results in the market.

Xia Meng, member of the 13th Chinese People’s Political Consultative Conference, vice president of China Documentary Society and national first-class screenwriter, made a speech.

  Xia Meng, member of the 13th Chinese People’s Political Consultative Conference, vice president of the China Documentary Society and a national first-class screenwriter, said that women-themed films have attracted worldwide attention. The performance of the actors in the movie Chang ‘an Chang ‘an is commendable. For example, Alima makes Ayana’s characters full of introverted tension through the expression, body language and inner feelings. Only when people’s hearts are connected can business cooperation be smooth. The film Chang ‘an Chang ‘an brings inspiration to filmmakers, and from a broader perspective, we can find movie themes in the lives of people in various countries.

Ekbel Mi Jiti, member of the 11th and 12th Chinese People’s Political Consultative Conference and executive vice president of China Film Literature Society, made a speech.

  Aikebaier Mi Jiti, member of the 11th and 12th Chinese People’s Political Consultative Conference and executive vice president of the China Film Literature Society, said that the key to popular support is cultural exchange. As a film jointly produced by many countries, the film Chang ‘an Chang ‘an fits the spiritual core of the "One Belt, One Road" initiative.

The cinema film "Chang 'an Chang 'an" expert viewing seminar was held in Beijing. Industry experts believe that it has filled the gap in the film with the theme of "Belt and Road" _fororder_ Hou Guangming, former party secretary of Beijing Film Academy, made a speech

Hou Guangming, member of the 13th Chinese People’s Political Consultative Conference and former Party Secretary of Beijing Film Academy, spoke.

  Hou Guangming, member of the 13th Chinese People’s Political Consultative Conference and former Party Secretary of the Beijing Film Academy, believes that the film Chang ‘an Chang ‘an is a realistic work with a unique theme. By showing the entanglement of marriage and family and self-redemption, it reflects the difficulty of transnational love and has rich connotations, which makes the film more realistic, durable and representative. The bold attempt of the film Chang ‘an Chang ‘an in multi-cultural presentation and multi-country joint shooting highlights the great potential of the film "going out" and hopes that the film Chang ‘an Chang ‘an will achieve good benefits in building a "Belt and Road" country.

Rao Shuguang, President of China Film Criticism Society, made a speech.

  Rao Shuguang, president of the China Film Criticism Society, said that the core of the film is human art. The plot logic of the film Chang ‘an Chang ‘an is clear, the narrative is smooth and the completion is high, and the pursuit of artistic differentiation and Chinese aesthetic spirit is seen. It is worth noting that the film also gives full play to the elements of Shaanxi opera, and at the same time, from the perspective of tourism, it naturally shows the two "Chang ‘an" in ancient and modern times, so that the audience can’t help but want to visit Xi ‘an. China’s films seek the greatest common denominator of different cultures in international cooperation, and the film Chang ‘an Chang ‘an has brought a lot of enlightenment.

Ban Yongji, former deputy director and first-class inspector of the Seventh Research Department of the Central Party History and Literature Research Institute, spoke.

  Ban Yongji, former deputy director and first-class inspector of the Seventh Research Department of the Central Party History and Literature Research Institute, said that the film Chang ‘an Chang ‘an is based on the story of Chinese traditional culture, refining the symbolic concept of cultural communication, expanding the connotation of Chinese culture in the times, and taking into account the cultural aesthetic demands of people from different countries. By telling the story of people from all countries knowing each other and loving each other, it shows the significance of building the "Belt and Road Initiative" to benefit the world.

Tang Ke, Deputy Director of Film Channel Program Center, made a speech.

  Tang Ke, deputy director of the program center of the film channel, said that the film "Chang ‘an Chang ‘an" is a work that conforms to the initiative of building the "Belt and Road" and promotes exchanges and mutual learning among civilizations; It is a work with multiple time-space narrative structures, which deepens the theme, enriches the connotation and can arouse the audience’s thinking. It is an online performance of actors, and the characterization is very successful, reaching a high artistic level.

Zhang Wei, Vice President of China Film Criticism Society, spoke.

  Zhang Wei, vice president of China Film Criticism Society, believes that the film Chang ‘an Chang ‘an shows the comparative reflection between contemporary life and ancient classics, the political demands and artistic themes go hand in hand, the triple narrative and the triple time and space care for each other, and the static performance and dynamic performance complement each other.

Zhao Weifang, Director of Film and Television Institute of China Academy of Art and Vice President of China Film Criticism Society, made a speech.

  Zhao Weifang, director of the Film and Television Institute of the Chinese Academy of Art and vice president of the China Film Criticism Society, said that the film Chang ‘an Chang ‘an is the embodiment of the creative transformation and innovative development of excellent traditional culture, and at the same time, the design of Iranian female films is seen in the film. In addition, the performance of actors such as Alima is also the highlight of the film.

The expert seminar on the cinema film Chang 'an Chang 'an was held in Beijing. Experts in the industry believe that it has filled the gap in the film with the theme of "Belt and Road" _fororder_ Zuo Heng, director of the film culture research department of China Film Art Research Center, made a speech

  Zuo Heng, Director of Film Culture Research Department of China Film Art Research Center, made a speech.

  Zuo Heng, director of the film culture research department of China Film Art Research Center, said frankly that Chang ‘an Chang ‘an put the grand narrative into the tiny relationship between two people, which brought enlightenment to the road of co-production in many countries. And this road needs more delicate movie stories and needs the careful care of filmmakers from many countries.

Chen Ruijun, a member of the Chinese Writers Association, spoke.

  Chen Ruijun, a member of the Chinese Writers’ Association, said that the film Chang ‘an Chang ‘an has a profound meaning and a moving story. It is not confined by the grand theme, but skillfully uses the ups and downs of personal destiny to connect the communication between countries building the "Belt and Road" in series, which is refreshing. I believe that the film will get good response in various countries.

  Multi-country cooperation to create China — Moving story of Central Asia

Speech by Lin Siwei, Deputy Director of China Film Archive and Deputy Director of China Film Art Research Center.

  As the organizer of the seminar, Lin Siwei, deputy director of China Film Archive and deputy director of China Film Art Research Center, said in his speech that the film "Chang ‘an Chang ‘an" is a vivid practice of close cooperation among filmmakers from many countries, actively responding to the initiative of building the "Belt and Road" and telling the story of the "Belt and Road" with movies. The film shows the modern symbols and historical and cultural elements of Xi ‘an, the starting point of the ancient Silk Road, realizes the presentation of multinational cultures and embodies the human values of innovation, cooperation and integration. China Film Archive will give full play to its own resources and provide support for the promotion, distribution and screening of the film Chang ‘an Chang ‘an and participation in international film festivals.

Speech by Liu Chi, Vice President of CCTV International Online

  In his speech, Liu Chi, vice president of International Online of China Central Radio and Television General Station, said that film, as an important link in the construction of international communication capacity and cultural soft power, is one of the important forms of cultural products for a country to spread abroad. In recent years, International Online has actively planned and promoted high-quality film projects under international cooperation, and the film Chang ‘an Chang ‘an is one of the achievements of innovative exploration. The film takes the Chinese-European tourist train as the story link, integrates the traditional cultural elements such as the Legend of the White Snake in the Qin Opera, and takes pictures in the cultural places such as the Mausoleum Museum of the First Qin Emperor and the City Wall of Xi ‘an, which makes the film Chang ‘an Chang ‘an full of the silk road spirit, rich cultural atmosphere and strong future expectations.

Shi Jia, a member of the Shaanxi Provincial Political Consultative Conference and producer of the film Chang ‘an Chang ‘an, introduced the film.

  Shi Jia, a member of the Shaanxi Provincial Political Consultative Conference and producer of the film Chang ‘an Chang ‘an, said that the two Chang ‘an in the film name, one representing the capital of the Tang Dynasty, an open and inclusive international metropolis, and the other representing Xi ‘an, which is building a national central city, complement each other. In addition, the story of the heroine in the film begins with the first special train from Almaty, Kazakhstan to Xi ‘an. On July 2-4, the Supreme Leader of president paid a state visit to the Republic of Kazakhstan. In a joint statement, the two countries pointed out that they are willing to jointly support the China-Central Asia humanistic tourism train, including exploring the first Xi ‘an-Almaty humanistic tourism train. The perfect coincidence of movie dream and development reality highlights the time value of the movie Chang ‘an Chang ‘an.

Zhong Zhang, director of the film Chang ‘an Chang ‘an, introduced the creative process.

  Zhong Zhang, director of the film Chang ‘an Chang ‘an, said that the film Chang ‘an Chang ‘an spans 30 years in time and space, and tells the story of the future time and space on the international tourist train in Central Europe in 2031. The film connects the future, the present and the past in series through the memories of women who have suffered from the marriage crisis, and shows her psychological course of self-healing from the perspective of a foreign woman, realizing reconciliation and connection between different countries, nationalities and people. The film is an exploration of international art forms, looking for people’s spiritual commonalities among different countries and nations.

The expert seminar on the cinema film Chang 'an Chang 'an was held in Beijing. Experts in the industry believe that it has filled the gap in the film with the theme of "Belt and Road" _fororder_ Alima, starring in the film Chang 'an Chang 'an, spoke.

  Alima, starring in the movie Chang ‘an Chang ‘an, speaks.

  Alima, the star of the movie Chang ‘an Chang ‘an, said in her speech: "I played Ayana, a character who realized self-reconciliation and redemption after experiencing the pain of transnational marriage. With the joint efforts of all the main creators, the film has received extensive attention, hoping to build a ‘ Belt and Road ’ Stories contribute their own strength. "

He Fei, Iranian producer of the film Chang ‘an Chang ‘an, spoke.

  He Fei, an Iranian producer of the film Chang ‘an Chang ‘an, said in his speech: "The filmmakers of Iran and China have overcome many difficulties and completed real cooperation, which makes the film Chang ‘an Chang ‘an meaningful. I look forward to more cooperation between Iran and China in the film industry in the future. "

Hu Die, producer of the film Chang ‘an Chang ‘an and general manager of Shaanxi Butterfly Effect Entertainment Media Co., Ltd., made a concluding speech.

  Hu Die, the producer of the film Chang ‘an Chang ‘an and the general manager of Shaanxi Butterfly Effect Entertainment Media Co., Ltd., said in his concluding speech that the film Chang ‘an Chang ‘an bears multiple meanings and echoes and interprets the spirit of the times contained in the initiative to jointly build the Belt and Road Initiative, hoping to convey the concept of openness and tolerance in the form of art and inspire people’s respect and appreciation for diversity.

  The film Chang ‘an Chang ‘an is created by China, Iranian and Kazakh filmmakers, and plays China — A film of transnational love in Central Asia. This film-watching expert seminar is not only a review and summary of the works, but also a discussion and prospect of the direction of literary and artistic creation in the new era, international cooperation and innovation, and China’s story expression, which will provide rich enlightenment for the internationalization of China films, empower China films and convey the voice of China.

  It is reported that the film "Chang ‘an Chang ‘an" expert viewing seminar was hosted by China Film Art Research Center and China Radio and Television General Station International Online, and was undertaken by China Film Newspaper and International Online Shaanxi Channel.

The data is right: "non-"general cooperation

  CCTV News:The 7th Beijing Summit of the Forum on China-Africa Cooperation was held in Beijing on September 3rd. Since its establishment in 2000, the Forum on China-Africa Cooperation has also celebrated its 18th birthday. In the process of continuous maturity, it has promoted the continuous expansion of China-Africa cooperation step by step. The growth track of 18 years has witnessed the deepening of China-Africa friendship, and the scope of cooperation has become broader. From trade, investment and infrastructure construction to personnel training, poverty reduction and income increase, medical assistance and people-to-people exchanges, China is helping Africa to achieve leap-forward development and integrate into globalization in all directions.

  18 years: the China-Africa Forum has been growing for 18 years and continuously implementing its commitment plan.

  Since the establishment of the China-Africa Cooperation Forum in 2000, China-Africa cooperation has been continuously expanded and deepened. The summit of the Forum on China-Africa Cooperation is held every three years, and the seventh Beijing Summit of the Forum on China-Africa Cooperation was held in Beijing from September 3rd to 4th. The theme of this summit is "win-win cooperation and work together to build a closer community of destiny between China and Africa". At the last China-Africa Cooperation Forum in 2015, China put forward ten cooperation plans between China and Africa, which opened a new stage of win-win and common development of China-Africa cooperation.

  Facts have proved that the Forum on China-Africa Cooperation has always played an important role in leading and promoting China-Africa relations in the past 18 years, and actively planned routes for China-Africa cooperation in different periods. Not only that, the forum has also become an effective help to expand the space for China-Africa cooperation. It is not difficult to see from the following figure that with the launch of sub-forums such as civil society and media, China-Africa cooperation has gradually expanded from the initial stage of the forum to the current all-round cooperation in many fields such as politics, economy, security, society, humanities and environment.

  Then, after 18 years of growth and deepening of the China-Africa Forum, what achievements have China-Africa "unusual" cooperation made? Let’s use the data to find out.

  Number one: the trade volume between China and Africa increased by 16 times in the first half of the year, and China was the largest trading country in Africa for nine consecutive years.

  The most direct aspect of China-Africa friendly cooperation is economic and trade exchanges. Since the establishment of the Forum on China-Africa Cooperation 18 years ago, the trade volume between China and Africa has increased from 10.6 billion US dollars to 170 billion US dollars, an increase of about 16 times.

  In the first half of 2018, the trade volume between China and Africa reached 98.8 billion US dollars, a year-on-year increase of 16%. China has been Africa’s largest trading partner for nine consecutive years since 2009.

  Hundreds of thousands of jobs: investment in Africa has created hundreds of thousands of jobs.

  In addition, China has become the country with the fastest growth rate of international investment in Africa, with the investment flow increasing from $200 million in 2000 to $2.4 billion in 2016, and the investment stock has also increased from less than $500 million to more than $38 billion in the same period.

  China’s investment in Africa has not only created hundreds of thousands of jobs, but also improved Africa’s infrastructure, upgraded Africa’s production technology, promoted Africa’s industrialization and modernization process, and strengthened the public opinion base of China-Africa cooperation.

  Over 5,000 kilometers: breaking through the bottleneck of infrastructure, opening up economic veins and building railways and highways over 5,000 kilometers.

  It is the common aspiration of African countries to break through the bottleneck of infrastructure and open up the economic veins.

  The Kenyan Munne Railway is one of the two most influential century projects undertaken by China on the African continent, and it is known as "the road to prosperity and development". In January this year, the first freight train of Inner Mongolia Railway was put into operation. At present, there are five freight trains running between Nairobi, the capital, and Mombasa, the largest port in East Africa, saving at least 40% of logistics costs. The Inner Mongolia Railway drives Kenya’s GDP growth by about 1.5% every year, creating 46,000 jobs directly for the local area. Since the reform and opening up, China has built more than 5,000 kilometers of railways and highways for African countries.

  In addition to helping traffic infrastructure construction, the expansion project of Kariba South Bank Hydropower Station, which was built by Chinese enterprises in Zimbabwe in southern Africa, was completed in March this year. The total installed capacity of Kariba Hydropower Station increased from 750,000 kilowatts to 1.05 million kilowatts, which increased the power supply for Zimbabwe by 20% to 30%, effectively alleviating the power shortage in the country.

  如今,从铁路、公路到机场、港口、水电站,中国承建的基础设施项目遍布非洲大陆,非洲国家正在逐步跟上经济全球化的步伐。

  15万人次:授人以渔 两年提供了15万人次的专业人才培训

  习主席曾深刻指出,中非关系最大的“义”,就是用中国发展助力非洲的发展,最终实现互利共赢、共同发展;不仅“授人以鱼”、提供不附加任何政治条件的对非援助,更要“授人以渔”、加强人力资源开发合作和技术交流。

  “与当地人才共同成长、与当地经济互利共赢”的中非合作模式,如今已遍及非洲大陆。自2015年年底中非合作论坛约翰内斯堡峰会以来,中国高度重视非洲发展能力建设,两年多来已向非洲国家提供了15万人次的专业人才培训,向非洲学生提供了3万个奖学金名额。

  今年6月,“蒙内铁路”承建中企发布报告显示,该项目已累计雇佣当地员工超过7.2万人,培养了数以万计的熟练工人和5000多名铁路技术人才;并通过合作办学,让超过2000名当地学生通过了铁路运营相关专业培训,他们将成为当地未来铁路运营、维护的中坚力量。

  Increase production by 140%: Promote rice planting techniques in China to increase production by 140% so that African people can get rid of poverty as soon as possible.

  China has always been anxious and considerate of African countries, as it has been for decades. The data shows that 70% of the population in Africa is agricultural, and the contribution rate of agriculture to Africa’s GDP is as high as 30%. However, many African countries have weak agricultural infrastructure, backward technology, frequent natural disasters and social unrest, and food security cannot be guaranteed. China put forward China-Africa cooperation plans such as "reducing poverty and benefiting the people" and "agricultural modernization", and once again stressed the need to share agricultural development experience with Africa, transfer applicable agricultural technologies and increase the income of local farmers.

  In China Agricultural Technology Demonstration Center, the rice yield per mu increased from 237kg to 570kg by 140% after adopting China rice planting technology.

  At present, China rice planting technology has more than 15,000 mu of high-yield demonstration model fields in the Dakawa rice-growing area of Morogoro province, which directly benefits more than 2,000 farmers. China has also built a farm in Zambia. Over the past 24 years, Zhongken Farm has solved the employment problem of more than 4,200 people and solved the food and clothing problem of more than 15,000 people — — After careful calculation, the farm supplies more than 45,000 tons of grain, 260 million fresh eggs and 3.71 million broilers and laying hens to the local market.

  Up to now, experts and technicians from China have implemented more than 300 small-scale demonstration projects in nine African countries, popularized 450 practical agricultural technologies and trained nearly 30,000 local farmers and technicians.

  Over 200 million: medical assistance relieves the pain of over 200 million African patients.

  In addition to solving the problem of "lack of food", the China-Africa cooperation project is also committed to alleviating the plight of African people who "look down on illness". In Zambia, over the past 40 years, there have been 20 batches of China medical teams with 546 members who have treated more than 3 million patients in Zambia, performed more than 20,000 operations of various types, and introduced and implemented more than 700 new technologies and projects.

  In 2006, 108,000 cases of malaria were reported in Comoros, resulting in 34 deaths. In 2007, the anti-malaria team from China entered Comoros. By 2014, only over 2,000 cases of malaria were reported in the whole country, and zero deaths were achieved.

  After the Ebola outbreak in West African countries in 2014, China took the lead in helping African brothers to fight the epidemic. For more than half a century, tens of thousands of foreign aid doctors in China have relieved more than 200 million African patients.

  23.7%: African students studying in China increased by 23.7% year-on-year during the five years of promoting cultural integration.

  Unusual cooperation has also promoted cultural exchanges between China and Africa. At present, there are nearly 2 million people-to-people exchanges between China and Africa every year, and China has opened more than 80 Confucius Institutes and classrooms in 41 African countries. In 2017 alone, China and Africa held more than 100 humanities exchange activities and implemented more than 200 humanities cooperation projects.

  Since 2000, the Summit of the Forum on China-Africa Cooperation has promised to provide funds and support for African education in China and abroad. According to statistics, during the five years from 2012 to 2016, the total number of international students from Africa in China was 61,594, which was the fastest growing among international students from all continents, with a year-on-year increase of 23.7%.

  One-third: in-depth cooperation for one-third of the world’s progress

  From brothers in distress to comprehensive strategic partners, China-Africa friendship has been deepening and China-Africa cooperation has been escalating. The data shows that the total population of Central Africa has exceeded 2.6 billion in 2017, accounting for about 35% of the world’s total population; Central Africa has a total land area of 39.8 million square kilometers, accounting for about 30% of the world’s total land area (except Antarctica). The progress of China-Africa relations under the guidance of the Forum on China-Africa Cooperation means that one-third of the world is advancing, which goes beyond the "holding a group to keep warm" among developing countries, and marks that South-South cooperation in the 21st century is glowing under the background of the new era and China’s efforts to build a community of global destiny.

  (CCTV reporter Zhu Ruijun Guan Weina)

A major breakthrough in non-invasive prenatal screening technology for fetal monogenic diseases

January 22, 2024, Academician Huang Hefeng, together with researchers from Zhejiang University and Fudan University, published the latest clinical research results in Nature Medicine, entitled Prospective Prenatal Cell-Free DNA Screening for Genetic Conditions of Heterogeneous Etiology. Using a new generation of non-invasive prenatal screening technology developed by our team, the clinical effectiveness of prenatal screening for fetal chromosomal diseases, microdeletion microreplication syndrome and monogenic diseases was verified in a prospective multicenter cohort study.

In this study, an innovative comprehensive non-invasive prenatal screening technology-synergistic allele-targeted enrichment sequencing was used to comprehensively screen different types of fetal genetic variation by detecting free DNA in maternal plasma. Studies have shown that this comprehensive non-invasive prenatal screening can accurately identify the fetal pathogenic variation at chromosome and monogenic level in high-risk pregnancy, which may improve the prenatal risk assessment of heterogeneous causes of genetic diseases, realize more accurate prenatal and perinatal medical management, and fill the gap in prenatal screening for new dominant monogenic diseases.

Research publication link:

https://www.nature.com/articles/s41591-023-02774-x#citeas

Academician Qiao Jie, Executive Vice President of Peking University/Director of Medical Department, Academician Yang Zhenglin, Dean of Sichuan Provincial People’s Hospital, Dean of Chongqing Women and Children Hospital (Chongqing Maternal and Child Health Hospital), and Qi Hongbo, Chairman-designate of Perinatal Branch of Chinese Medical Association, commented on this achievement.

Academician Qiao Jie pointed out in his comments, "The biggest innovation of this clinical study by Academician Huang Hefeng is to include monogenic diseases in the scope of non-invasive prenatal screening. This progress not only significantly improves the detection rate of fetal genetic diseases, but also provides safer, timely and accurate information for pregnant women and doctors in the decision-making and management of pregnancy, marking an important breakthrough in the field of genetic diseases and birth defects prevention and control."

Academician Yang Zhenglin pointed out in his comments that "the dominant monogenic disease caused by new mutation is the weak link in the current prenatal screening, and it is an inevitable trend for NIPT to include it in the comprehensive screening of fetal cfDNA. The research of Academician Huang Hefeng’s team not only proposed a novel and efficient technical path, but also demonstrated the clinical effectiveness of related technologies, providing important theoretical and practical basis for further improving prenatal diagnosis and prevention and treatment of hereditary birth defects. "

Dean Qi Hongbo pointed out in his comments, "This three-in-one comprehensive screening method has significantly improved the detection rate and demonstrated high accuracy, which proves its great potential in clinical application. If this method can be popularized in clinic, it will effectively fill the gap in prenatal screening for dominant monogenic diseases, which is of great practical significance for improving China’s prenatal screening system and prevention and control of birth defects. "

What is prenatal non-invasive screening?

Noninvasive prenatal screening (NIPS): It is a kind of prenatal screening technology. The screening targets are mainly trisomy 21, trisomy 18 and trisomy 13, which are common fetal chromosomal diseases. After 2013, it quickly integrated into the prenatal screening system and became the most effective and widely used prenatal screening method.

At present, non-invasive prenatal screening (NIPS) detects aneuploidy or microdeletion/microdeletion syndrome by analyzing fetal free DNA(cfDNA) in maternal peripheral blood. Because most of the maternal plasma cfDNA comes from the mother, it is difficult to detect fetal specific variation in high maternal background, and many hereditary diseases can not be detected at present.

What is comprehensive non-invasive prenatal screening technology?

Comprehensive non-invasive prenatal screening (cfDNA comprehensive screening) technology covers three main human genetic variations, namely chromosome aneuploidy, chromosome microdeletion and single gene variation, which expands the detection range of non-invasive prenatal screening and improves the detection accuracy, and is of great significance in the field of prenatal screening.

What did the study find?

The team established a new targeted enrichment method-COATE-SEQ (Figure 1), which realized multi-dimensional analysis of maternal and fetal free DNA, solved many technical defects of the first generation NIPT, and realized non-invasive prenatal detection of fetal chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic disease at the same time for the first time.

Figure 1 New generation NIPS technical process

This study evaluated the clinical effectiveness and increased detection efficiency of this new generation NIPS technology through a multicenter prospective clinical study lasting nearly 2 years.

During the period from April 24th, 2021 to September 10th, 2022, 1191 pregnant women (age ≥20 years, single pregnancy ≥12 weeks, abnormal fetal structure (including NT≥3mm), high risk of NIPT or maternal serological screening, or high risk of genetic diseases due to previous pregnancy history) from three maternity hospitals in different provinces of China were included in the study, and all the participants underwent a comprehensive prenatal cfDNA screening. Finally, the screening results of 1,090 pregnant women who met the criteria for ovulation were analyzed. Pathogenic genetic variation was detected in 135 cases (12.4%) of pregnancy through comprehensive cfDNA screening, which was confirmed by diagnostic tests, including 89 aneuploidies, 9 microdeletions and 37 single gene variations (Figure 2). Compared with the current standard screening for chromosomal abnormalities (NIPT), the detection rate of diagnostic genetic variation in comprehensive cfDNA screening increased by 60.7%, the sensitivity was 98.5% (95% CI, 94.3%-99.7%), and the specificity was 99.3% (95% CI, 98.4%-99.7%).

Figure 2 Detection rate of genetic variation in pregnancy with abnormal fetal structure

Among 876 cases of pregnancy with abnormal fetal structure, 98 cases (11.2%) detected diagnostic gene variation. Among them, 42 cases were autosomal aneuploidy (42.9%), 13 cases were sex aneuploidy (13.3%), 6 cases were microdeletion (6.1%) and 37 cases were single gene (37.8%). B in 876 cases of pregnancy with abnormal fetal structure, the detection rate of diagnostic genetic variation was the highest in lymphatic or hydrops abnormalities (36.9%), followed by skeletal abnormalities (24.7%) and multiple system abnormalities (23.3%). The highest detection rate of chromosomal abnormalities was lymphatic or hydrops abnormalities (32.6%), followed by multiple system abnormalities (19.2%), thickening of the transparent layer behind the neck (8.8%), heart defects (5.7%) and craniofacial abnormalities (5.7%). The highest detection rate of single gene abnormality is skeletal abnormality (23.5%), followed by lymphatic or hydrops abnormality (4.3%), multi-system abnormality (4.1%), FGR(2.9%) and brain developmental abnormality (2.2%).

What is the significance of this research?

Incorporating chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic diseases into fetal cfDNA screening is beneficial to prenatal diagnosis, can be used as an auxiliary tool for early identification in the first trimester of pregnancy, supplement the current imaging-based methods, and is also beneficial to prenatal screening and perinatal management. When pregnant women with abnormal fetus choose to continue pregnancy and refuse invasive surgery, this screening becomes particularly important. Comprehensive NIPS screening can provide more accurate prenatal screening for a wide range of hereditary diseases and provide valuable help for risk assessment and timely management of pregnancy.

Correspondents of this study are Zhejiang University/Director of Key Laboratory of Reproductive Genetics/Academician Huang Hefeng and Researcher Zhang Jinglan of Fudan University, Zhang Dan of Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Xu Chenming of Obstetrics and Gynecology Hospital affiliated to Fudan University and Wang Hua of Hunan Children’s Hospital. The co-first authors are Luo Qiong, the Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Wu Yiting and Chen Songchang, the Obstetrics and Gynecology Hospital affiliated to Fudan University, and Xi Hui, the Maternal and Child Health Hospital of Hunan Province. Chen Yuan, Jiang Ying, Chen Panpan, Liu Yifeng and Dong Min Yue also participated in the study.

It is the eternal pursuit of the development of non-invasive prenatal screening and the long-term research and development goal of the medical community to screen more kinds of important fetal genetic diseases simultaneously with a tube of maternal peripheral blood more accurately and efficiently.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is the leading unit of Zhejiang Prenatal Diagnosis Center, Zhejiang Fetal Medical Diagnosis and Treatment Center, Zhejiang Prenatal Diagnosis (Screening) Quality Control Center, Zhejiang Obstetric Medical Quality Control Center, Zhejiang Critical Pregnant Women Treatment Center, Zhejiang Remote Fetal Heart Monitoring and Interpretation Center, Zhejiang Labor Analgesia Technical Guidance Center, Zhejiang Maternal and Child Nursing Specialist Nurse Training Base and other institutions.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is a national key clinical specialty, a key (supporting) discipline in Zhejiang Province, and the leader unit of Zhejiang perinatal health care cooperation group. The annual delivery volume exceeds 20,000 person-times, among which the high-risk pregnancy exceeds 80%, the proportion of serious, difficult and critical cases exceeds 35%, and the success rate of maternal rescue basically reaches 100%. It has formed sub-specialties such as maternal medicine, fetal medicine and general obstetrics, and opened more than 20 specialty clinics such as fetal medicine clinic, prenatal diagnosis consultation clinic and gestational diabetes clinic. It has a very high rescue success rate for difficult and critical patients such as pregnancy complicated with refractory heart failure, pre-eclampsia critical state, acute fatty liver of pregnancy, amniotic fluid embolism, adult respiratory distress syndrome, severe prenatal hemorrhage and severe postpartum hemorrhage. In the basic and clinical research of pregnancy-induced hypertension, the diagnosis and treatment of intrahepatic cholestasis of pregnancy, the treatment of intrauterine growth retardation, the prognosis evaluation of intrauterine brain diseases and intrauterine kidney diseases, intrauterine fetal surgery such as fetal mirror, delivery room surgery, gestational diabetes mellitus, various fetal intrauterine monitoring, painless delivery and other fields, fruitful results have been achieved; He has accumulated rich clinical experience and management ability in premature delivery, premature rupture of membranes, twins, cervical incompetence, early-onset preeclampsia and early-onset intrahepatic cholestasis of pregnancy. It is an early large-scale unit in China to carry out prenatal diagnosis and fetal monitoring, and has established a prenatal screening system-prenatal diagnosis system-prenatal diagnosis management system.To make a multi-level cross-study on complicated and difficult fetal birth defects.

Source | Zhejiang University Women’s Hospital

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Celebrating the "Busy Year" in the Year of Reunion | Saying "Sacrifice the Kitchen in the Small Year"

  Today is the 23rd day of the twelfth lunar month, a traditional "off-year" in China.

  "Twenty-three, candied melons stick", with the coming of the Lunar New Year, the pace of the Lunar New Year is getting closer and closer.

  General Secretary of the Supreme Leader stressed: "The Spring Festival is a beautiful moment to bid farewell to the old and welcome the new, which will always bring people new expectations." The Spring Festival is not an isolated festival, but a festival group that integrates folk customs such as getting rid of old cloth and making new ones, and worshipping gods and ancestors. From the eighth day of the twelfth lunar month to the fifteenth day of the first lunar month, there are different traditional Spring Festival customs almost every day.

  The old customs bear profound historical and cultural connotations and reflect people’s deep feelings and sense of identity with Chinese excellent traditional culture. Many traditional customs originated from the actual needs of ancient society. With the changes of society, they gradually surpassed the practicality and became the symbol of our nation’s common memory and cultural heritage, which is a vivid portrayal of the enduring and handed down from generation to generation of Chinese civilization. In addition, the annual custom activities in different places have their own characteristics, which bring together the cultural essence of all parts of the country and also show the inclusive characteristics of traditional culture.

Celebrating the "Busy Year" in the Year of Reunion | Saying "Sacrifice the Kitchen in the Small Year"

  Off-year is also called "Lunar New Year Festival" in ancient times, which means before and after beginning of spring, at the turn of Lunar New Year Festival. Off-year is usually regarded as the beginning of a busy year, which means that people begin to prepare new year’s goods, sweep dust, offer sacrifices to stoves, etc., and prepare for a clean and good year.

  The written record about the off-year was first seen in the Eastern Han Dynasty. In the Eastern Han Dynasty, Cui Mao’s "Four People’s Month Order" contained: "La will be updated tomorrow, which means that it is a young age, and it is respected by the wine, and it is a teacher." In fact, the origin of off-year can be traced back to the Xia Dynasty, which originated in honor of a great god respected by the people. Later, in the pre-Qin period, a god was set up in the kitchen, and drinks, fruits and food were used as sacrifices.

  It is worth mentioning that the holiday date of off-year is different in the north and the south, with the 23rd off-year of the twelfth lunar month in the north and the 24th off-year of the twelfth lunar month in the south. The different dates of off-year between the north and the south are related to the tradition of "three officials, three people, four boats and five people" in ancient China [i], that is, the official family celebrated off-year on the 23rd of the twelfth lunar month and the people celebrated off-year on the 24th of the twelfth lunar month. Because the north is close to the capital and is greatly influenced by bureaucracy, the off-year is changed to the 23rd of the twelfth lunar month, while the south still maintains the original tradition of celebrating off-year on the 24th of the twelfth lunar month. Therefore, the off-year in the north is one day earlier than in the south.

  Offering sacrifices to stoves is the most important activity on off-year day, so off-year is also called "Festival of offering sacrifices to stoves" and "Kitchen God Festival". Sacrificial stoves have been in China for thousands of years. The belief in Kitchen God is a reflection of Chinese people’s dream of "having enough food and clothing". According to legend, the Kitchen God is an official who is arranged by the Jade Emperor to manage various kitchen fires on earth. On the 23rd of the twelfth lunar month, he reports to the Jade Emperor about the good and evil of this family in a year, and then rewards and punishments are implemented according to the Jade Emperor’s will. People are afraid that the kitchen god will talk nonsense after going to heaven, so they offer sacrifices to the kitchen stove on the off-year day and send sweet offerings such as candy and rice cakes. I hope he will be sweeter and say some nice words to make people’s lives easier in the coming year [ii]. Therefore, there is also the custom of eating stove candy on this day of off-year, which is very sticky, so it is also called "gum candy", commonly known as "Guandong candy" in Beijing, and "sugar ingot" in Shanghai and Jiangsu.

  Besides offering sacrifices to stoves, there are other customs in off-year life. For example, in the off-year in the north, families get together to eat jiaozi, which means to see the Kitchen God off and to "see off the windward side of jiaozi". In the south, families get together to eat rice cakes, which means that people’s work and life are improved year by year. Of course, there are customs such as cutting window grilles and bathing.

  As the prelude to the Spring Festival, off-year has always maintained its unique charm and significance, which contains profound cultural significance. These colorful folk activities express people’s good wishes to bid farewell to the old and welcome the new. At the same time, the differences in dates and customs between the north and the south also reveal the inclusiveness and diversity of China culture.

  

  Poster: Wang Jinhong and Wang Yiting (internship)

  Copywriter: Wang Ruoxin and Huang Sijin (internship)

  

  [i] traditional customs [J]. Health and wellness of traditional Chinese medicine, 2016, (Z1): 11-20.

  [ii] Wang Jijin. Prosperous China Year — — Endless old customs [J]. Jiangxi Education, 2023 (04): 6-9.

  

Investigation on Certification of Healthy Vegetables: Does the price of ordinary vegetables increase 10 times when you spend some money on branding?

  Xinhua News Agency, Jinan, August 10th Question: Does the price of ordinary vegetables increase 10 times when you spend some money on branding? — — Health vegetable certification chain tracking

  Xinhua News Agency "Xinhua Viewpoint" reporters Shao Kun, Richard Chang and Wang Yang

  At present, in large supermarkets in many cities, besides ordinary bulk vegetables, there are often sales areas for brand vegetables. Unlike ordinary vegetables, which are sold in large quantities, these vegetables are mainly packaged in small packages such as 2 onions, 3 cucumbers and 4 peppers, and are labeled as "pollution-free", "green" and "organic".

  The price of branded vegetables is several times higher than that of ordinary vegetables, and the price of organic vegetables is as high as 10 times. However, some insiders revealed that some of the "aristocrats" in these vegetables are not true, but they are actually ordinary vegetables, and the qualified rate of organic vegetables is even less than 10%.

  Although the price of healthy vegetables is high, the profits of farmers and enterprises are not high.

  On July 30, the reporter saw in Shanshui RT Mart Supermarket in Jinan that the price of ordinary bulk tomatoes was 1.99 yuan per catty, and the price of a brand of tomatoes labeled "green" was 14.8 yuan per catty; Bulk cucumber is sold in 2.3 yuan per catty, and the price per catty with brand and "green" label is 6.8 yuan. On the e-commerce platform, the online sales price of a certain brand of organic tomatoes is 25 yuan per catty, which is more than 10 times that of ordinary tomatoes.

  Although the price of green and organic vegetables sold in supermarkets is high, the income of vegetable farmers has not increased much.

  Dailou Village, Heguan Town, Qingzhou City, Shandong Province, is a concentrated vegetable planting area. Liu Guanjun, a vegetable farmer, once supplied a brand of green vegetables. He said that green vegetables have high requirements on pesticide residue standards and quality, and each batch should be sampled. In order to meet the supply requirements, it is necessary to make insect nets and use biological pesticides, which takes a lot of time. Calculated, the cost of cucumber per mu will increase by more than 500 yuan, but the output is about 1000 kg lower.

  Enterprises that operate high-end vegetables also feel that the profits are not great.

  Ci Runyu, chairman of Youwo Organic Agriculture Co., Ltd. said that in order to manage organic vegetables, the company did not plant anything on the land in the first three years, but buried soybean meal and slowly "raised" the land to meet the requirements of organic soil standards. "It has been six years since we started to make organic vegetables, and we are losing money every year. We are ready to lose money for eight years."

  Li Aihong, deputy general manager of Shandong Liaoyuan Science and Technology Co., Ltd. said, taking green cucumbers as an example, in order to make vegetable farmers motivated, the company’s purchase price is 20 cents higher than the market price per catty, and the cost per catty is at least increased by 1 yuan. In addition, there are expenses such as employee salaries, logistics and transportation, and supermarket shopping guide salaries.

  Zhu Zaijun, chairman of Shouguang Vegetable Farmers’ Home Association, said that in the supermarket, the cost of sales has suddenly increased. In some supermarkets, the entrance fee is as high as 20%, and the admission fee is charged by category, and the settlement time is more than half a month.

  "The sales volume of green vegetables is only about one tenth of that of ordinary vegetables. If vegetables can’t be sold, they will rot. According to the price, it is good that the payment rate can exceed 70%. " Li Aihong said.

  Li Aihong said: "Without pesticides and fertilizers, the labor cost is greatly increased. Real organic vegetables can only be guaranteed at a price several times or even 10 times that of ordinary vegetables. "

  In addition to cost and market problems, the most worrying thing for green vegetable operators is that this high-end vegetable market is full of mixed fish and dragons. Some merchants use ordinary dishes to imitate green and organic dishes, which leads to a large number of shoddy products entering the market, and even to a certain extent, the phenomenon that bad money drives out good money.

  A green vegetable dealer said that some companies that produce ordinary vegetables are not certified, but they also imitate the packaging of green vegetables, and their appearance is very similar. "They sell as much money as we sell, and consumers mistakenly think that they are all the same." He said.

  Cui Dayou, head of Junhui Farm in zouping county, Shandong Province, has been engaged in organic agriculture for 8 years and has cooperated with famous hotels and restaurants in Jinan and Zibo. "They used organic dishes several times and thought it was really good, but they didn’t need it after the high cost. They can continue to pretend to be our brand." Cui Dayou said that he had seen vegetables sold under the banner of his enterprise in other places, but at first glance they were not produced.

  Counterfeiting happens from time to time, and certificates can be handled with money.

  It is understood that the standards of pollution-free, green and organic vegetables are different. Pollution-free means that pesticides and fertilizers are allowed to be used, but highly toxic and residual pesticides cannot be used; Green is a transitional product from pollution-free to organic development; Organic standards have the highest requirements, not only prohibiting the use of pesticides and fertilizers in the production and processing process, but also having strict requirements on the surrounding planting environment such as soil and water quality. It is considered as pure natural, pollution-free, safe and nutritious food, and almost becomes synonymous with health.

  Although the price is higher, with the concept of green consumption deeply rooted in people’s hearts, high-end healthy vegetables are increasingly welcomed by the people.

  According to the statistics of the Ministry of Agriculture, since the green food project was started in 1990, there have been more than 10,000 green food enterprises in China, with nearly 25,000 products and a base area of nearly 200 million mu. Some products have accounted for 5% to 8% of the total amount of major agricultural products. Since the certification of organic agricultural products in the agricultural system was launched in 2003, there are nearly 1,000 certified enterprises and 4,000 products in China, and the number is still increasing.

  So, are the vegetables with various certification labels genuine?

  A number of business leaders engaged in vegetable production and management said that it would be a good achievement for vegetables that really meet the organic standards in the market. "The certificate agency has been commercialized, and it can be done with money." A person in charge of the company said.

  The reporter learned that there are many certification bodies of organic certificates, such as Zhonglv Huaxia and Wuzhou. Some online agencies say that they can handle the certificates of these institutions, and the processing period ranges from two months to six months.

  The reporter contacted an agency. The salesman said that it costs 26,000 yuan for the organic certification of Zhonglv Huaxia, and the other 18,000 yuan. When asked if "the use of chemical fertilizers and pesticides will fail the audit", the business person said, "Don’t have these things on site during the inspection, and the products can’t be detected."

  The reporter’s investigation found that there are also gaps in product testing. According to the accreditation process, after the on-site audit, the inspector will issue on-site inspection of pesticide residues, heavy metals and other items. Then the inspected person sends the sample to a laboratory in Beijing for testing and pays the testing fee.

  The salesman reminded me that because it is self-inspection, we should try our best to select products that have no problems and mail them to the testing center, which will generally pass smoothly. The certification of Zhonglv Huaxia is difficult to pass. If the vegetables produced use pesticides and fertilizers frequently, other units can be certified.

  According to the relevant regulations, there should be no pollution sources such as garbage dumps and chemical plants around the planting base of organic vegetables. However, the business person said that the plants planted in the village can generally be used, and there is no clear requirement on the distance. The minimum requirement is "invisible" and everything else can be operated.

  Many vegetable producers said that even with organic certificates, it is difficult for products to truly achieve organic quality. According to the standard, using chemical fertilizers and pesticides once cannot be called organic. However, it is impossible for technicians to stare at cooperatives and farmers every day, and it is impossible for inspectors to stay in greenhouses 24 hours a day. "Quality mainly depends on the self-discipline of production enterprises and farmers." A manufacturer said.

  Enhance the credibility of green certification and establish a traceability system for enterprises.

  In 2017, the No.1 Document of the Central Committee emphasized that the authority and influence of domestic green and organic agricultural products certification should be accelerated, and the credibility of green food brands should be enhanced in a more prominent position.

  How to solve the phenomenon that ordinary vegetables pretend to be green, organic and other high-end vegetables for sale? Agricultural experts said that some certification bodies are unprofessional and irresponsible because of the low threshold for certification bodies and the lack of supervision over certification activities. After the approval of certification, due to personnel and energy, post-certification supervision is not in place.

  Zhou Qingjie, a professor at the School of Economics of Beijing Technology and Business University, said that at present, all kinds of food certification in China are mainly base certification rather than product certification, and the certification industry is developing abnormally. The number and frequency of vegetable trading are large, but the production subject is not organized and the scale is small, so it is very difficult to supervise.

  Experts put forward the following suggestions: open the information of certified enterprises and accept the supervision of the government and the public; Improve the qualification threshold of certified enterprises and establish a professional team; Introduce third-party supervision in the authentication process.

  Ma Aiguo, the chief animal husbandry minister of the Ministry of Agriculture, has publicly stated that it is necessary to bring the quality sampling inspection of green food and organic agricultural products into the scope of routine monitoring, law enforcement sampling inspection and risk assessment monitoring. Resolutely crack down on signs infringement, counterfeiting and nonstandard use of marks and other phenomena and behaviors. It is reported that in 2016, China cancelled the right to use the logo of 110 green food products.

  Zhu Zaijun said: "To produce high-quality agricultural products, enterprises must establish a closed system that can be traced back to the whole process of production, brand maintenance and sales."

  Liu Tongli, deputy head of the Agricultural Economics Sub-committee of Shandong Agricultural Expert Advisory Group, suggested that the management department should strengthen online monitoring of production bases to reduce OEM counterfeiting. In addition, it is necessary to strengthen the detection of vegetables and make the results public to consumers.

  In fact, only from the appearance and taste, it is difficult for ordinary consumers to distinguish whether vegetables are ordinary or green and organic. Li Aihong reminded that when buying vegetables, don’t just look at the appearance packaging, but also carefully read the contents on the label. Some high-priced vegetables that don’t have a "green" or "organic" logo must be counterfeit high-end vegetables.

A US judge issued a historic ban to prevent Biden’s government from contacting social media companies.

  Republican Attorneys General in two states of the United States filed a lawsuit accusing Biden’s government of interfering with social media content. In response to the lawsuit, a federal judge in the United States issued an injunction prohibiting major agencies and officials of Biden’s government from meeting and communicating with social media companies on "protected speech".

  The case may have a profound impact on the First Amendment, marking a key turning point in the partisan struggle over social media speech in the United States for several years, which may have a major impact on technology companies.

  On July 4, local time, a federal judge in the United States banned major agencies and officials of Biden’s government from meeting and communicating with social media companies on "protected speech." This is an unconventional preliminary injunction involving an ongoing case that may have a far-reaching impact on the First Amendment.

  The media is worried that this move by the judge appointed by former US President Trump may ruin years of efforts to strengthen coordination between the government and social media companies. For more than a decade, the US federal government has been trying to cooperate with social media companies to solve criminal activities, including child sexual abuse images and terrorism.

  This ruling may have a major impact on technology companies, because technology companies communicate with government officials regularly, especially during emergencies such as elections and epidemics. As American courts are increasingly forced to weigh such issues, it may subvert the legal norms governing online speech for decades.

  The White House retorts that social media platforms should consider the impact on the American people.

  The ban was in response to lawsuits filed by Republican attorneys general in Louisiana and Missouri, who claimed that government officials had gone too far in encouraging social media companies to deal with posts that might cause people to hesitate to get vaccinated or subvert elections during the epidemic. Legal experts believe that these cases may eventually be submitted to the Supreme Court.

  In the past five years, when the United States accused Russia of spreading false information during the 2016 election, the US federal government responded to the increasing election intervention and voter repression, and the coordination and communication between government officials and technology companies have been strengthened. During the COVID-19 epidemic, public health officials often communicated with social media companies, because false information about viruses and vaccines spread on social networks such as Facebook, Twitter and YouTube. Evelyn Douek, an assistant professor at Stanford Law School, told Washington post: "The scope of the ban is extremely broad, obviously to prevent any form of contact between government actors and social media platforms."

  Judge Terry A. Doughty has not yet made a final ruling on the case, but when he issued the injunction, he said that he might side with the Republican Attorney General and think that Biden’s government violated the First Amendment.

  The judge’s order restricted some executive agencies in the federal government, including the Ministry of Justice, the the State Council, the Department of Health and Human Services, and the Centers for Disease Control and Prevention, and named more than a dozen officials, including Alejandro Mayorkas, Secretary of Homeland Security, and Jen Easterly, head of the Cyber Security and Infrastructure Security Bureau.

  In addition to restricting the communication between the government and technology companies, Doughty also prohibited these institutions and officials from cooperating, coordinating and establishing partnerships with major academic groups focusing on social media, including the Election Integrity Partnership, the researchers’ alliance led by the Internet Observatory of Stanford University and the Informed Public Center of Washington University.

  In the order, the judge made some exceptions to the communication between government officials and companies, including warning of national security threats, criminal activities or suppressing voters. Duke said that the exemption list highlighted the thorny issues in the case, but the order lacked clear guidance on "where is the boundary".

  A White House official said that the Justice Department "is reviewing the court’s injunction and will evaluate its options in this case". The official said: "This government advocates taking responsible actions to protect public health, safety and security in the face of challenges such as deadly epidemics and foreign attacks on our elections." "Our consistent view remains that social media platforms have an important responsibility to consider the impact of their platforms on the American people, but to make independent choices about the information they provide."

  Google, one of the companies named in the lawsuit, did not immediately respond to requests for comment. Meta, Facebook’s parent company, declined to comment, and Twitter did not respond to requests for comment.

  Republican victory

  The lawsuit marks a key turning point in the partisan struggle over social media speech in the United States for several years. For years, Republicans have believed that the policies of social media companies to deal with false information related to elections and public health have led to the censorship of their political views. At the same time, Democrats argue that these companies have not done enough to regulate their services to ensure that they do not undermine democracy.

  What is unusual about this lawsuit is that it is not aimed at technology companies, because technology companies claim that they have the First Amendment right to determine the content displayed on the website, but at the role of the federal government in this process. This is the most successful legal effort in this regard so far.

  The Republican state attorney general believes that Biden’s administration threatened to take legal action against technology companies when the comments on the platform caused controversy, which violated the First Amendment. They cited the Biden administration’s threat to take anti-monopoly actions against these companies or to revoke Section 230, which is a legal shield to protect technology giants from lawsuits. (For details, please refer to 澎湃 Technology Report "The US Supreme Court opens the trial of the fate of big technology companies: whether to cancel the 27-year Internet" umbrella "? 》)

  The Trump administration has also put forward similar arguments in its struggle with social media companies. In 2020, Trump signed an executive order instructing the Federal Communications Commission to reconsider the scope of Section 230. In the same week that the order was issued, Twitter put a fact check tag on Trump’s two tweets.

  According to reports, this case is based on tens of thousands of communications between Biden government officials and social media companies, including emails and text messages, which mainly occurred between 2020 and 2021. The attorney general of the above-mentioned state believes that from 2017, four years before Biden became president, internal government officials began to lay the foundation for a "systematic movement" to control social media speech.

  However, although Biden and dozens of officials from 11 government agencies were listed as defendants in the lawsuit, some examples cited occurred during Trump’s administration.

  Since the acquisition of Twitter last year, elon musk has been echoing the views of the Republican Party, releasing internal company documents to selected journalists, implying that Twitter colluded with government officials. Although this is far from being confirmed, some documents disclosed by Musk eventually appeared in the arguments of the lawsuit.

  Defendants, social media companies and experts who study false information say there is no evidence that the government systematically censors individuals in violation of the First Amendment. David Rand, an expert on misinformation at MIT, told The New York Times that his understanding is that the government has limited influence on how social media platforms handle misinformation.

  Jamir Jaffer, executive director of the Knight First Amendment Institute of Columbia University, said: "The government cannot violate the First Amendment simply by interacting with the platform on its content review and policy." "If this is what the court said, then this is a rather radical proposition that is not supported by case law."

Alfa T5 special edition of polar fox with dynamic pull will be unveiled at Guangzhou Auto Show.

Recently, it was reported that the Extreme Fox Alfa T5 special edition will be unveiled at the 2024 Guangzhou Auto Show, with a dynamic blue-green design and a 5C fast charging system, which can be fully charged in 12 minutes in theory. At present, the price range of Extreme Fox Alpha T5 is 15.58-19.98 million yuan. It is positioned as a pure electric medium-sized SUV, integrated with 800V fast charging function, and launched two endurance versions of 520 km /660 km.

In terms of appearance, the front face of Alfa T5 adopts closed design, and the grille part adopts narrow strip type and is connected with headlight groups on both sides, which stretches the visual width of the car. At the same time, there are raised ribs on the engine room cover, and the design of diversion grooves is added to the two sides surrounded below the front line to increase the sense of movement.

On the side of the car body, it can be seen that the new car adopts a slightly raised waistline and slightly raised wheel eyebrow lines at the front and rear, which greatly enhances the design sense with the hidden door handle. In addition, the car is equipped with dense-spoke bright black wheels and red brake calipers. In terms of body size, its length, width and height are 4690/1936/1650mm and its wheelbase is 2845 mm. The rear part of the car adopts a penetrating taillight group with blackening treatment inside, which is very dynamic with the large diffuser on the tailgate.

For the interior, the Alfa T5 adopts a minimalist design, and the central control part is not equipped with a separate LCD instrument except the multimedia large screen. In addition, the new car is also equipped with a two-spoke steering wheel and a two-color interior color scheme. In the configuration part, the new car provides 6 airbags, millimeter-wave radar inside the roof (to detect the vital signs in the back row of the car), Qualcomm 8155 chip, four-zone intelligent voice interaction, 256-color atmosphere lights, panoramic canopy and so on.

The power is driven by pure electricity, and the maximum power is divided into two versions: 185kW and 200kW. The batteries are also available in Ferrous lithium phosphate and ternary lithium. In addition, the new car is also equipped with 800V high-voltage overcharge, which can achieve 260 kilometers in 10 minutes. The battery capacity is 65kWh, 79.2kWh and 85.8kWh, and it is available in 520km and 660km battery life versions.

[The picture in this article comes from the network]

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车系eπ008以其流线型的侧面设计展现出优雅的车身轮廓,车身尺寸为5002mm x 1972mm x 1732mm,轴距长达3025mm,营造出宽敞的内部空间。其前后轮距均为1650mm,确保了良好的行驶稳定性。轮胎规格采用了265/45 R21,不仅提升了操控性能,同时也赋予了车辆独特的视觉冲击力。轮圈风格精致且动感十足,为整体侧面设计增添了一抹运动气息。

泸州eπ008汽车最新价格18.86万,降价促销,特价打折优惠2.8万,不容错过

eπ008的内饰设计彰显了精致与科技感的完美融合。采用现代皮质方向盘,不仅触感细腻,还配备了手动上下+前后调节功能,确保驾驶者舒适度。中控台的核心是一块15.6英寸的高清触控屏幕,集成多媒体系统、导航与电话功能,操作便捷,娱乐性能强大。座椅方面,采用仿皮材质,前排座椅提供加热和通风功能,驾驶位和副驾驶位还有电动记忆功能,确保长途驾驶的舒适性。副驾驶座椅同样支持前后、靠背和高低调节,而第二排座椅支持前后调节和腿托调节,空间利用十分人性化。整体内饰注重实用性和人性化设计,为乘客营造出宽敞、科技的驾乘环境。

泸州eπ008汽车最新价格18.86万,降价促销,特价打折优惠2.8万,不容错过

车系eπ008搭载了一款1.5T涡轮增压发动机,其最大功率达到了108千瓦,拥有210牛·米的峰值扭矩,为车辆提供强劲的动力输出。配合电动车单速变速箱,这种配置确保了车辆在行驶中的高效能和稳定性。

总结汽车之家车主的评价,eπ008无疑在性价比、工艺品质与舒适性上都赢得了车主的认可。其坚实的底盘结构确保了驾驶稳定性,而内饰的无异味则展现了对细节的关注。外观设计的整洁度再次证明了它的高品质追求。在诸多优点的加持下,eπ008无疑为消费者提供了值得信赖的驾驶体验。

Changchun eπ 008 is on sale, the latest offer 188,600! Sufficient car

[Autohome Changchun Discount Promotion Channel] Recently, we learned from official channels that the model is undergoing a large-scale promotion in Changchun, with a maximum discount of 28,000 yuan and a minimum starting price of 188,600 yuan. For friends who have recently purchased a car, now is the best time to start this model. Please click "Check the car price" in the quotation form to get a higher discount.

长春eπ008特价出售,最新报价18.86万!现车充足

eπ008以其独特的前脸设计引人注目,整体呈现出一种未来感。其进气格栅采用封闭式设计,完美融合了科技感和时尚感。车身线条流畅,整体风格简约而不失动感。

eπ008车身尺寸为5002mm*1972mm*1732mm,轴距达到3025mm,展现出宽裕的车内空间。车侧线条流畅,配合21英寸的轮圈,采用265/45 R21的轮胎规格,整体造型运动且充满科技感。

长春eπ008特价出售,最新报价18.86万!现车充足

eπ008的内饰设计采用了简约而现代的风格,营造出科技感与舒适性的完美结合。中控台配备了15.6英寸的高清触控屏幕,支持语音识别控制系统,能够控制多媒体、导航、电话和空调等多种功能,极大提升了驾驶体验的便捷性。方向盘采用皮质包裹,手感细腻,支持手动上下和前后调节,以适应不同驾驶者的使用需求。座椅则采用仿皮材质,提供了良好的支撑和舒适度,主驾驶位和副驾驶位均配备了加热和通风功能,确保在各种天气条件下都能保持舒适的乘坐体验。此外,主驾驶位座椅还配备了头枕扬声器,带来更加沉浸式的听觉享受。车辆还配备了多个USB和Type-C接口,以及前排的手机无线充电功能,为乘客提供了便利的电子设备充电需求。第二排座椅同样具备多向调节功能,包括前后调节、靠背调节和腿托调节,使得后排乘客也能享受到个性化的乘坐体验。

长春eπ008特价出售,最新报价18.86万!现车充足

eπ008搭载了一款1.5T涡轮增压发动机,最大功率为108kW(147马力),峰值扭矩达到210N·m。这款发动机采用直列四缸布局,为车辆提供了强劲的动力输出。配合电动车单速变速箱,使得动力传递更加高效直接。

汽车之家车主 对eπ008给予了高度评价,他提到:“车身整体设计大气,非常耐看,看上去像30多万的车~”这样的赞誉无疑是对eπ008外观设计的认可,相信它会成为更多消费者的理想选择。

On the 10th anniversary of the P series, Huawei launched a "treasure box": subverting the folding screen mobile phone experience

After the large-screen straight-board form of smartphones became popular in people’s lives, it has been a well-developed design for so many years, and in the past two years, there has been almost no gap in configuration. Manufacturers have less and less room to play, and consumers have less and less choice. It is easy to experience aesthetic fatigue.

However, in the past two years, there have also been some very fresh blood in the mobile phone market, that is, a new form of folding screen mobile phone. According to the latest authoritative data released by iResearch, in the context of the continuous decline in the overall shipment of smart phones, the shipment of folding screen mobile phones in China in the past two years is growing, and it is expected that the global shipment of smart phones will rebound in the future.

These data also mean that the folding screen will be the next trend in the mobile phone market, and Huawei has realized the layout in advance before the trend arrives. In the past two years, it has continuously promoted the iteration of folding screen mobile phones.This year’s Mate X2 is already very mature, accounting for nearly 70% of the Chinese folding screen mobile phone market, and has become the absolute leader in the folding screen market.

However, Huawei is not satisfied with this, but hopes to stand higher and fly farther in the future of the folding screen.

On December 23rd, Huawei officially released the first vertical folding screen mobile phone Huawei P50 Pocket, which is Huawei’s new layout in the folding screen market and a new breakthrough on the occasion of the tenth anniversary of the birth of the P series.

First of all, it can be seen at a glance from the appearance that the Huawei P50 treasure box is a stylish and portable folding screen mobile phone, which is folded up and down and has a smaller body.

Huawei’s first longitudinal folding flagship, creating a new generation of water drop hinges to "erase" creases

As a folding screen mobile phone, a foldable screen must be a top priority in design. The Huawei P50 treasure box has innovatively adopted a new generation of water drop hinges unique to the industry, allowing the phone to form a water drop-type screen space at the bend, solving the problem of the fuselage gap in the folded state.

At the same time, Huawei also uses a multi-dimensional linkage lift design in the folding structure, which can push the screen as the screen unfolds and folds, making the folding screen smooth and smooth. The crease problem is also greatly reduced. In actual use, it is almost impossible to feel the many pain points of the previous folding screen mobile phone, allowing the folding screen mobile phone to enter the practical stage.

In addition, Huawei did not focus all its energy on folding design, but still brought a screen with excellent display quality.Equipped with a 6.9-inch flexible inner screen, it supports up to 120Hz smart refresh rate, 442ppi, 1.07 billion color, etc., and adopts a 21:9 ratio, whether it is swiping text information or watching games, it can bring a broader field of vision and a stronger sense of immersion.

This screen is also covered with a new nano-optical film, which can achieve ultra-low screen reflectivity, effectively reducing the impact of screen creases on the visual experience, and will no longer have creases all over the eyes under strong light.

The first double-sided three-dimensional micro-engraving process makes the mobile phone as bright as a diamond, the perfect folding screen flagship for the lady

On the back design, the crystal diamond white color scheme of Huawei P50 treasure box adopts unique double-sided three-dimensional micro-engraving process glass, and engraves 1000 diamond-shaped squares, which can bring reflected light and shadow like diamonds and achieve new aesthetic breakthroughs.

It is not difficult to see from the design of this back case,Huawei P50 treasure box will be a folding screen phone that is highly sought after by female users, allowing female users to hold it in their hands like a vanity case, which is completely different from previous folding screen phones that were mostly male and favored hardcore technology.

It is worth mentioning that the Huawei P50 treasure box also continues the P50 series double ring rear camera scheme in the ID design. The two rings on the top of the back make it clear at a glance that it belongs to the P50 series, which is in the same vein as the P series Vientiane double ring design.

But the difference is that the ring under the Huawei P50 treasure box is actually a delicate round screen.It can conveniently display time, notifications and other information, and can operate main functions such as notifications, schedules, calendars, music, weather, wallet payment, etc. without opening the lid.

HarmonyOS + folding screen ecological alliance makes folding screen easy to use and easy to use

With the blessing of Hongmeng Ecology, the HarmonyOS service card was brought.You can directly open the services of many third-party applications such as Alipay, Autonavi Maps, Meitu Xiuxiu and other third-party APP.These are the ecology and innovation that Huawei has continuously developed in the field of folding screens in recent years, which will eventually make folding-screen mobile phones easier to use.

It is reported that Huawei has taken the lead in establishing a folding screen ecosystem alliance since launching folding screen products in 2019, and through close cooperation with developers, has promoted the adaptation of third-party apps and folding screens.

In addition, based on its strong soft and hard coordination and ecological capabilities, Huawei can also make the inner and outer screens work in perfect relay on the P50 treasure box.

For example, after receiving a notification on the external screen and clicking on the preview, opening the screen will directly enter the notification interface, and the reply message will arrive instantly; while on the phone, it is more convenient. When an incoming call is made, the external screen will directly display the incoming call information. In this case, the screen can be opened to answer directly. The experience is similar to the flip machine in earlier years, and the whole process is very smooth and natural.

Top three-camera module + secondary screen preview, Huawei P50 treasure box can be called a selfie artifact

The most important thing is that the addition of this sub-screen also makes the selfie effect more powerful, you can directly link with the main camera module, preview the picture in real time and complete the selfie, in the 40 million pixel primary color lens + 13 million pixel ultra-wide-angle lens + 32 million pixel hyperspectral lens Under the combination of three cameras, it can bring stronger and more natural selfie image quality, blurring effect, etc., seconds become selfie artifact.

In addition, the Huawei P50 treasure box rear camera module also integrates a 10-channel multispectral sensor, flash, hyperspectral fill light, laser focus sensor, based on the hyperspectral fill light and macro shooting capabilities, Huawei has brought a new shooting gameplay – fluorescence photography.

This function allows users to use the Huawei P50 treasure box in their hands to take beautiful fluorescent pictures that are difficult to see with the naked eye in nature, such as shooting flowers in a dim light environment, you will see a different fantasy world. And with the blessing of the hyperspectral imaging system, Huawei Mirror also brings professional-grade skin detection function. Through AI accurate identification, hyperspectral depth analysis, real-time sunscreen detection, intelligent reminders, and sun protection suggestions are given.

This combination of top-level hardware, innovative interaction, and application ecology has allowed Huawei’s P50 treasure box to truly transform from usable to easy-to-use and easy-to-use, and even endowed it with fashionable attributes through ID design, which is no longer exclusive to hardcore players. This has greatly promoted the further popularization of folding screen mobile phones.

If you have the opportunity to experience the Huawei P50 Pocket, you must give it a try. It may change your previous opinion of folding screen phones.The Huawei P50 Pocket is priced at 8988 yuan and will be officially launched at 18:08 on December 23 in Huawei Mall, major e-commerce platforms, Huawei Authorized Experience Stores, and Huawei Authorized Distributors.

Huawei also launched a broken screen service treasure and an extended service treasure for the P50 treasure box. The broken screen service treasure covers the inner and outer screens, and you can enjoy a low-cost service fee to change the screen after the broken screen. You can also get a battery renewal service within two years when you buy with the new machine. The extended service treasure is to extend the one-year warranty service period for the equipment host on the basis of the standard warranty service period. Users who need it can go to Huawei malls, retail stores, and service stores to buy with the new machine.

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Please indicate the source when reprinting: Fast Technology

#Folding screen phone #Huawei P50 Pocket

(Editor in charge: Lee Hsien Kit)