标签归档 南京新茶外卖论坛

In 2020, China’s economy will strive for progress and start a new journey —— Experts and scholars look forward to the economic trend of China.

  Editor’s note: 2020 is the year of building a well-off society in an all-round way and ending the 13th Five-Year Plan. In the face of the complicated situation that risks and challenges at home and abroad are obviously rising, how can China achieve high-quality economic development in the new year? How to activate dormant development potential?

  Many experts and scholars believe that we should not only see that China is in the key period of transforming the development mode, optimizing the economic structure and transforming the growth momentum, but also see that we have a solid material and technical foundation accumulated for a long time, a super-large-scale market advantage and domestic demand potential, and huge human capital and talent resources. In the future, we will be able to overcome all kinds of risk challenges, and China’s economy will be even more splendid.

  Feng Qiaobin, Deputy Director of Macroeconomic Research Department of the State Council Development Research Center:

  The characteristics of economic "gaining momentum" are very obvious

  Looking forward to 2020, the external environment of China’s economic growth is still complex and severe.

  From the international environment, 2020 is still in a long-term bottoming period, and the world pattern is uncertain.

  From the internal environment, the supply-side factors that determine China’s long-term growth have undergone major changes, and the potential economic growth rate has declined. The new kinetic energy represented by the digital economy is growing rapidly, but it is still in a small and scattered stage compared with the traditional kinetic energy. From the demand side, the import and export are unstable, the consumption is stable and slightly slow, the investment has declined, and the pulling force of the "troika" has weakened.

  More importantly, there are many optimistic and positive factors in China’s economic growth in 2020. Since the end of 2019, countries have taken a series of measures to stimulate and boost the recession, such as the Federal Reserve’s three consecutive interest rate cuts and Japan’s fiscal stimulus plan. These measures are expected to produce practical results in early 2020. At the same time, China is still in the middle and late stage of industrialization and urbanization, the historical depth of economic development is still broad, the supply-side factor conditions continue to upgrade, and the demographic dividend is being transformed into talent dividend and engineer dividend. At the same time, funds are abundant, scientific and technological innovation is changing with each passing day, and the digital economy is moving towards traditional manufacturing, and the whole economy is very obvious.

  Therefore, the main task of macroeconomic management in 2020 is to continue to create and maintain the overall environment for balanced economic operation. It is necessary to maintain a normal mind about the speed of economic growth, not to be overly worried about short-term fluctuations, and to take more measures to ensure that the macroeconomic operation is in a reasonable range of around 6%.

  In terms of fiscal policy, we should continue to implement the policy of reducing taxes and fees, and further activate the endogenous motivation of market players. We will issue 3.15 trillion yuan of local government special bonds and launch a number of large projects such as sichuan-tibet railway, which will effectively stabilize the stable operation of China’s economy from the investment side.

  In terms of monetary policy, while maintaining a reasonable and abundant liquidity, efforts should be made to unblock the transmission mechanism of monetary policy and effectively alleviate the problem of financing difficulties for private enterprises.

  In addition, strengthen the coordination among fiscal policy, monetary policy, industrial policy, regional policy and employment policy, ensure that China’s economy operates in a reasonable range, create conditions for promoting reform, restructuring and preventing risks, and turn to high-quality development at an early date, successfully complete the tasks of the 13 th Five-Year Plan and the year of building a well-off society in an all-round way, and lay a solid foundation for opening a new journey of modernization.

  (Reporter Lin Huocan finishing)

  Zhao Ping, researcher of China Council for the Promotion of International Trade Research Institute:

  The upgrading of consumption structure has been enhanced.

  In 2020, the global economy is expected to achieve recovery growth, China’s economy will remain stable and positive, the business environment will continue to improve, the system and mechanism of consumption growth will be further improved, the factors restricting consumption growth will be alleviated, and new consumption highlights will continue to emerge. The annual consumption growth will continue to improve, which will play a fundamental role in the rational growth of economic aggregate and the steady improvement of development quality.

  From the international situation, global economic growth will be better than that in 2019. According to the forecast of the International Monetary Fund, the uncertain factors of economic growth in emerging economies will fade in 2020, which can offset the negative impact of the slowdown of capital expenditure in developed economies and drive the global economic growth to rebound. It is estimated that the global economic growth rate will increase from 3% in 2019 to 3.6% in 2020, and the global trade growth will return to 3.2%. The warmer global economic situation is conducive to enhancing the supporting role of China’s export-oriented economy in domestic consumption growth.

  From a policy perspective, the institutional mechanism for promoting consumption growth will be more perfect. In 2020, the country will still attach importance to giving full play to the basic role of consumption. The Central Economic Work Conference clearly stated that it is necessary to guide funds to invest in advanced manufacturing, people’s livelihood construction, infrastructure shortcomings and other fields that benefit both supply and demand, and promote the "double upgrade" of industry and consumption. This is to promote consumption upgrading through the improvement of supply quality and level, so as to smooth the economic cycle between supply and consumption and ensure a smoother consumption growth mechanism.

  From the perspective of consumption growth, new consumption highlights continue to appear. From January to November 2019, the total retail sales of social consumer goods increased by 8.0% year-on-year. After deducting automobile consumption, the growth rate of retail sales of consumer goods can reach 9.0%. Due to the continuous decline of automobile consumption in 2019, the accelerated adjustment of automobile industry structure and the increasing ability to adapt to consumer demand, the year-on-year decline of automobile consumption in 2020 is expected to narrow, or even turn from negative to positive.

  At the same time, the motivation for upgrading the consumption structure continues to increase. The overall consumption structure will still maintain the pattern of two-wheel drive of commodity consumption and service consumption. Among them, within the commodity consumption, the characteristics of quality, individuality and diversification are more prominent. While consumers get material satisfaction, they have higher and higher demand for spirit. Pursuing both internal and external cultivation through consumption behavior will become a new trend of consumption. Compared with commodity consumption, the growth rate and proportion of service consumption continue to increase, especially the consumption of transportation, communication, education, culture, entertainment and medical care will still maintain high growth, and the growth rate will be higher than the total retail sales of consumer goods in the same period.

  (Reporter Feng Qiyu finishing)

  Zhu Caihua, Deputy Director of Foreign Trade Institute of International Trade and Economic Cooperation Research Institute of Ministry of Commerce:

  Strong foreign trade foundation and strong toughness.

  In 2019, China’s foreign trade showed strong resilience and maintained a stable operation in general, under the pressure of economic transformation and the headwind of protectionism. Looking forward to 2020, China’s foreign trade situation is still grim, but its resilience remains the same.

  First of all, Sino-US economic and trade friction and global value chain reconstruction are still the biggest risks. At present, China and the United States have reached an agreement on the text of the first phase agreement, and the United States has promised to cancel some of the proposed tariffs and tariffs imposed on China. This will help to temporarily improve the bilateral trade between China and the United States. However, it is undeniable that the tariff increase that has not been completely eliminated will still affect the development of bilateral trade between China and the United States, and the uncertainty of US trade policy toward China will bring the risk of global value chain reconstruction.

  Secondly, global economic growth will pick up and the external market environment will tend to improve. According to the forecast of the International Monetary Fund (IMF), the global economy will grow by 3.0% in 2019, which is the weakest year since the international financial crisis. In 2020, it will go out of the bottom and reach 3.4%. If China and the United States can eliminate all tariff increases, this year’s economic growth forecast is expected to be further raised. In addition, the growth expectations of emerging economies, including Argentina, Turkey, Brazil, Mexico and Russia, have improved significantly, providing a good external environment for market diversification.

  Thirdly, the adjustment of domestic industrial structure is accelerating, and new kinetic energy will provide strong help. At present, China’s economy is transforming from a high-speed growth stage to a high-quality development stage, and a new round of scientific and technological revolution and industrial transformation continues to deepen. The newly revised Guiding Catalogue of Industrial Structure Adjustment (2019 edition) issued by the National Development and Reform Commission puts the high-quality development of manufacturing industry in a more prominent position, and at the same time emphasizes accelerating the transformation and upgrading of traditional industries and vigorously cultivating and developing emerging industries. This will certainly help the foreign trade industry to change birds, provide new kinetic energy for China’s foreign trade development, and effectively hedge the risks brought about by the transfer of some manufacturing industries.

  Finally, the measures of "stabilizing foreign trade" continue to land, and the policy effect will be further revealed. In 2019, various "stable foreign trade" policies and measures were introduced in time and effectively landed, which contributed to maintaining a stable operation of foreign trade as a whole. In 2020, the effect of the policy of reducing fees and taxes will continue to appear and the business environment will continue to improve. A series of policies provide all-round and guiding practical guidance and policy framework for China’s foreign trade to achieve high-quality development, which will help to further lay a solid foundation, enhance motivation and expand depth for foreign trade development in 2020.

  (Reporter Feng Qiyu finishing)

  Li Changan, Professor of university of international business and economics School of Public Administration:

  Achieve fuller and higher quality employment.

  2020 is the year to build a well-off society in an all-round way, and it is also the decisive year to achieve the goal of the first century.

  Employment is the greatest livelihood. Doing a good job in employment is the premise of ensuring the smooth realization of various economic and social development goals and the objective requirement of practicing the people-centered purpose.

  In the new year, China’s employment work is facing both rare opportunities and great challenges. The increasingly complex domestic and international situation has brought great uncertainty to the stable development of China’s economy and society, and also brought great difficulties to stabilizing employment. We must be soberly aware that insufficient employment and low quality of employment are the main contradictions in China’s employment field for a long time at present and in the future, and the problem of insufficient employment still exists. At present, judging from the registered unemployment rate in cities and towns and the survey unemployment rate indicators, employment has remained basically stable as a whole. However, this does not mean that the employment pressure will be reduced.

  In terms of labor supply, China’s urban labor supply will still exceed 15 million in 2020, including about 8.5 million college graduates, plus vocational school graduates and those who will not continue their studies after junior high school and high school, about 7 million people. In addition, nearly 10 million rural laborers are transferred every year, and together with nearly one million urban laborers who are re-employed, the total supply of employment is still very large, and the contradiction between supply and demand is more prominent.

  At the same time, the problem of low employment quality is more prominent. Although the quality of employment in China has been improved in recent years, the low quality of employment is still a prominent contradiction in the field of labor and employment. This is mainly manifested in the low average wage level of workers, persistent wage arrears, unstable employment, imperfect social security and long working hours. Some workers have a low sense of acquisition, and it is a long way to go to achieve decent employment.

  To meet the challenge, we must firmly grasp the main contradiction and solve the key problems in the field of employment in the next step of employment work. First of all, we should continue to implement the employment priority policy and realize the coordination between the employment policy and other macro-control policies; Secondly, continue to tap the potential of expanding employment and increase employment opportunities in high-quality development and economic restructuring and upgrading; Finally, we attach great importance to the education and training of the labor force and improve the ability of workers to adapt to changes in the labor market. In this way, the goal of promoting full and higher quality employment can be successfully achieved.

  (Reporter Han Bingzhi finishing)

  Guo Liyan, Researcher, Institute of Market and Price, China Macroeconomic Research Institute:

  There is no basis for overall price increase.

  From the macro-economic fundamentals, the transformation of old and new kinetic energy of China economy is obviously accelerated, the resilience and vitality of the domestic market are further enhanced, and the economy achieves a dynamic balance between supply and demand at a higher level, which is the key cornerstone for maintaining a stable overall price level. Domestic industrial and agricultural production is stable, the market supply is sufficient, the main grain income is increased, apples, pears and other fruits are high, and the supply capacity of vegetables continues to grow. Although the scale of pig slaughter has declined, the overall supply of meat protein is stable, and there is no basis for overall price increase.

  At present, the pork reserve has maintained considerable strength and rhythm, the import of meat has been accelerated, the market circulation and supply channels have been fully unblocked, and an efficient and effective combination boxing has been played. In December 2019, the probability of the growth rate of pork prices turning from positive to negative is very high. This is a positive signal released after taking multiple measures to increase the efforts to ensure supply and stabilize prices. In addition, considering the factors such as consumption substitution, the seasonal increase of consumption in 2020 will be obviously less than that in previous years, and it is expected that the price of pork and other meat will hardly continue to rise sharply in the first half of 2020.

  Taking all factors into account, it is predicted that the overall situation of stable price operation in 2020 is completely predictable, and the CPI is likely to show a trend of high before and low after. In the first half of the year, the high tail-warping has a greater impact, which may support the CPI to run at a higher level, especially when the Spring Festival is in January. The Spring Festival effect will lift the year-on-year increase of CPI at the beginning of the year, but the new price increase range is controllable. The annual CPI increase may be slightly higher than that in 2019, and the core CPI excluding food and energy will remain stable.

  From the PPI point of view, at this stage, the supply-side structural reform has entered the stage of consolidating and establishing a long-term mechanism. The price increase effect caused by accelerated supply contraction such as quantitative de-capacity and environmental protection and limited production in the early stage has basically been released. In addition, due to the downward fluctuation of international commodity prices, it is expected that the prices of upstream industrial raw materials will remain at a low level for some time in the future. At present, the counter-cyclical adjustment policy is making efforts to improve efficiency, which has played a positive role in boosting infrastructure, especially new infrastructure, stabilizing social investment and residents’ consumption expectations. The downstream industrial demand and construction demand have picked up regionally, which has led to a phased increase in the prices of some industrial products such as building materials. It is expected that the PPI will show a slight rebound in 2020 and will remain stable overall.

  (Reporter Lin Huocan finishing)

  Ni Pengfei, Director of Urban and Competitiveness Research Center of China Academy of Social Sciences:

  The property market will operate within a reasonable range.

  On the whole, on the basis of 2019, the property market will remain in a reasonable range in 2020, and the trend of "steady seasonal change and continuous differentiation" will not change.

  First of all, there will be no drastic fluctuations in the property market in 2020 without a major policy shift. At present, the interest mechanism of real estate speculation has not been completely eliminated, and financial institutions still tend to invest their funds in the real estate field. At the same time, due to the relatively few investment tools and the lack of export of residents’ funds, some people still use real estate as a hedge tool. Judging from the trend of the real estate market, the existing problems and the impact of the property market on the macro economy, the determination of the state to regulate the property market will not change, and the regulation will not be relaxed in 2020. In the future, with the improvement of regulation system and mechanism, the real estate market will continue to operate within a reasonable range.

  Secondly, the property market will have ups and downs and fluctuations in individual time periods. In individual months, house prices may increase to some extent, but there may also be negative growth in a certain period of time. In addition, real estate investment may continue to maintain the trend of high before and low after many years. On the one hand, the property market will be in fluctuation due to the impact of external environment, changes in its supply and demand relationship and expected changes. On the other hand, in order to ensure the stable and healthy development of the real estate market, the regulatory policies will be continuously fine-tuned according to the current or future possible changes in the property market — — When the market rises to a certain extent, the regulation will be overweight; When the market drops to a certain extent, the regulation will be relaxed.

  At the same time, from a spatial perspective, cities will continue to differentiate. For first-and second-tier cities, the upward pressure on the property market will increase in 2020, and the growth rate of prices, sales and investment will fluctuate. However, for third-and fourth-tier cities, the downward pressure on the property market will be further enhanced, and inventory may increase again. It is worth noting that the economy and population of first-and second-tier cities, metropolitan areas, cities with special resources, cities with four or five lines and below, and cities with exhausted resources will continue to differentiate.

  In addition, from the perspective of real estate market risks, the overall decline is controllable. But at the same time, there is also the possibility of risk amplification in individual areas, links, subjects and regions of the property market. (Reporter Wang Yuchen finishing)

Attention! The latest release of Shaanxi CDC

  Today (June 1), Shaanxi Provincial Center for Disease Control and Prevention issued a health reminder for June, especially reminding people to pay attention to novel coronavirus infection, hand, foot and mouth disease, epidemic hemorrhagic fever, brucellosis, rabies, respiratory infectious diseases and food-borne diseases.

  First, novel coronavirus infection

  As of early May, XBB series mutants have become the main epidemic strains in Covid-19, China. Compared with the early epidemic branches in Omicron, the pathogenicity of XBB series mutants has not changed significantly. It is suggested that people should continue to do personal protection and health management.

  Health tips

  (1) It is suggested that those who meet the requirements should be vaccinated with Covid-19 vaccine as soon as possible without any contraindications. The target population of vaccination at this stage is: ① people who are not infected and have not completed the established immunization program. Including uninfected people aged 3-17 who have not completed basic immunization, uninfected people aged over 18 who have not completed the first dose of booster immunization, and uninfected people aged over 18 who have not completed the second dose of booster immunization; ② People who have been infected and have not completed basic immunization.

  (2) Do a good job in daily protection. Wear masks scientifically, pay attention to hygiene habits, wash hands frequently, pay attention to cough etiquette, gather less, open windows regularly at home and workplace for ventilation, and do a good job in daily hygiene in the room.

  (3) Strengthen personal health management. Pay close attention to your family and your own health every day. If you have symptoms such as fever, dry cough, fatigue, sore throat, decreased sense of smell, diarrhea, etc., avoid going to school or work with illness, and go to a fever clinic in a nearby hospital as appropriate. Wear a mask all the way to the hospital and try to avoid taking public transport.

  (4) Once infected with Covid-19, it is recommended not to go out unless necessary, to avoid going to crowded public places, not to participate in gathering activities, and to wear masks all the time. During the period of living at home, infected people should reduce close contact with their roommates, do a good job in self-health monitoring, and see a doctor in time if necessary.

  Second, hand, foot and mouth disease

  Hand, foot and mouth disease (HFMD) is a common infectious disease in children caused by enterovirus infection, mostly in children under 5 years old. The monitoring data over the years show that April-July is the main epidemic season of hand, foot and mouth disease in Shaanxi, and it has entered a high incidence period.

Attention! The latest release of Shaanxi CDC

  Health tips

  (1) Vaccination with EV71 vaccine can effectively prevent hand, foot and mouth disease caused by EV71 virus and effectively reduce the risk of severe illness and death.

  (2) Pay attention to hand hygiene, especially before touching the nose and mouth, before meals, after defecation, or after going out and going home, after touching herpes/respiratory secretions, after changing diapers or handling articles contaminated by feces, wash your hands with flowing clean water+hand sanitizer or soap to guide children to master the "seven-step washing method".

  (3) Pay attention to ventilation, and open the window for ventilation 2-3 times a day. During the epidemic of hand, foot and mouth disease, try to avoid taking children to places where people gather and the air circulation is poor.

  (4) Always change and dry clothes, bedding, towels and diapers; Clean and disinfect toys, personal hygiene utensils, tableware and other items every day.

  (5) Pay attention to the health status of children. Once there is fever, rash (especially perianal rash) or oral ulcer, go to medical institutions in time. Delayed treatment or misdiagnosis may easily lead to the development of children into severe cases and even lead to death.

  (6) Nursery institutions should strictly implement measures such as morning and afternoon check-up, absence from class due to illness, epidemic report, ventilation and disinfection, etc., report sick children in isolation in time, and do a good job in the discovery, response and disposal of aggregated and outbreak epidemics.

  Iii. Epidemic hemorrhagic fever

  Hemorrhagic fever is a natural epidemic disease caused by Hantavirus, with rodents as the main source of infection, and the incidence rate is high among farmers who often work or have activities in the field. In the recent summer harvest season, outdoor activities and field work have increased the chances of contact with rodents and their pollutants. It is recommended that the masses do a good job in protection.

  Health tips

  (1) Vaccination is the most important and effective measure to prevent hemorrhagic fever. Vaccination should be carried out in time and in the whole process according to relevant vaccination requirements.

  (2) Strengthen personal protection and develop good hygiene habits. Try to avoid contact with rats and their excreta pollutants, and don’t stay overnight in outdoor places such as orchards to prevent mites from biting; Rodent control measures can be implemented for a long time in key places such as villages, orchards, vegetable gardens and farms.

  (3) Do not eat cold food, water, etc., especially those contaminated by rodents; Wear masks, hats and gloves when cleaning up messy things and wastes (such as straw and corn stalks).

  (4) In case of fever, muscle soreness, skin bleeding and other symptoms, you should go to the hospital in time.

  Fourth, brucellosis

  Brucellosis (brucellosis for short), also known as lazy disease, is a zoonotic infectious disease caused by brucellosis. Sheep, cattle and pigs suffering from brucellosis are the main sources of brucellosis in human beings, and it is clinically characterized by long-term fever, sweating, fatigue, joint pain, hepatosplenomegaly and lymphadenopathy.

  Health tips

  (1) Buy sheep from a regular sheep farm without brucellosis epidemic, and conduct quarantine and immunization on the sheep regularly.

  (2) Livestock should be kept in captivity, separated from humans and animals, avoiding water sources, and not scattered and mixed.

  (3) Occupational people engaged in livestock breeding, fur and milk meat processing, veterinarians, etc., should take personal protection in the process of occupational contact such as breeding, wear work clothes, masks, rubber gloves and other protective articles, and do not directly contact with sick livestock products. At the same time, Ying Qin should wash hands and disinfect, change clothes, maintain environmental hygiene, and conduct regular physical examination, and treat suspicious symptoms in time.

  (4) Pay attention to food safety, do not drink raw milk or eat raw meat, and separate raw and cooked chopping boards when cooking.

  Five, rabies

  Summer is the high incidence of dog injuries. The sultry weather can easily make dogs fidgety and impulsive. At the same time, people wear thin clothes in summer and are easily bitten and scratched by dogs.

Attention! The latest release of Shaanxi CDC

  Health tips

  (1) Scientifically manage pets. Families who keep pets should apply for dog registration certificate, vaccinate their pets in time, and keep their pets in captivity, and don’t abandon them at will.

  (2) When walking dogs, dog chains, muzzle covers and dog cages should be used to control the range of activities and behaviors of dogs and avoid the occurrence of dog injuries.

  (3) Avoid contact with wild animals and stray animals, do not tease and play with cats, dogs and other animals, do not disturb dogs that are eating, sleeping or caring for their cubs, and do not let animals lick skin wounds.

  (4) After being bitten by dogs, cats and other animals, you should go to the nearby standardized dog injury treatment clinic as soon as possible.

  (5) In contrast, children are more dangerous to be bitten. The bitten wound is deep and serious, and the closer it is to the head, neck, face and hands, the more dangerous it is, which requires special attention. It is necessary to strictly wash the wound, inject immunoglobulin, choose more efficient vaccine and vaccinate according to the procedure.

  Six, respiratory infectious diseases

  June is still the high incidence season of respiratory infectious diseases such as mumps, scarlet fever, chickenpox, rubella and measles, and schools and kindergartens should be alert to the outbreak of the epidemic.

  Health tips

  (1) Vaccinate infectious diseases such as measles, chickenpox, mumps, etc. which are prevented by vaccines in time and in the whole process according to relevant vaccination requirements.

  (2) Pay attention to good personal hygiene habits, wash your hands frequently, cover your nose and mouth with paper towels when sneezing and coughing, and do not touch your eyes, mouth and nose with your hands. Wash and dry clothes and bedding frequently.

  (3) Open the window regularly for ventilation several times every day to keep the indoor air fresh.

  (4) Try to avoid going to crowded places, wear a mask when there are symptoms such as fever, sore throat and cough, and reduce contact with others.

  (5) Schools and child care institutions should focus on preventing small-scale outbreaks of respiratory infectious diseases, strengthen environmental sanitation and ventilation and disinfection of classrooms in schools, and implement measures such as morning and afternoon inspection, absenteeism registration and epidemic report.

  Seven, food-borne diseases

  The weather is getting hotter and hotter, and the rising temperature creates conditions for the proliferation of bacteria, food is more prone to decay and deterioration, and food-borne diseases have also entered a high incidence period.

  Health tips

  (1) Develop good personal hygiene habits, wash your hands before and after meals, after touching dirty things and before processing and making food, and disinfect tableware regularly.

  (2) canteens and families should strictly control the quality of food, and must not buy spoiled poultry, eggs, meat and aquatic products for the sake of greed.

  (3) Pay attention to kitchen and food hygiene, and separate raw and cooked chopping boards when cooking; Do not eat food that is not thoroughly cooked, and do not drink unclean raw water; Eat as much food as possible, eat little or no leftovers, and put them in the refrigerator if there are any leftovers. When eating out, you must pay attention to choosing a regular restaurant or restaurant with good sanitary conditions.

  (4) Pay attention to insects and rats indoors, and strengthen the sanitary management of feces, garbage and sewage.

  (5) If there are symptoms such as diarrhea, fever, abdominal pain and bloody stool, you should go to the hospital in time.

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  Source: Shaanxi CDC

  Editor | Long Yi

  Edit | He Ye

[Editor in charge:

]

A major breakthrough in non-invasive prenatal screening technology for fetal monogenic diseases

January 22, 2024, Academician Huang Hefeng, together with researchers from Zhejiang University and Fudan University, published the latest clinical research results in Nature Medicine, entitled Prospective Prenatal Cell-Free DNA Screening for Genetic Conditions of Heterogeneous Etiology. Using a new generation of non-invasive prenatal screening technology developed by our team, the clinical effectiveness of prenatal screening for fetal chromosomal diseases, microdeletion microreplication syndrome and monogenic diseases was verified in a prospective multicenter cohort study.

In this study, an innovative comprehensive non-invasive prenatal screening technology-synergistic allele-targeted enrichment sequencing was used to comprehensively screen different types of fetal genetic variation by detecting free DNA in maternal plasma. Studies have shown that this comprehensive non-invasive prenatal screening can accurately identify the fetal pathogenic variation at chromosome and monogenic level in high-risk pregnancy, which may improve the prenatal risk assessment of heterogeneous causes of genetic diseases, realize more accurate prenatal and perinatal medical management, and fill the gap in prenatal screening for new dominant monogenic diseases.

Research publication link:

https://www.nature.com/articles/s41591-023-02774-x#citeas

Academician Qiao Jie, Executive Vice President of Peking University/Director of Medical Department, Academician Yang Zhenglin, Dean of Sichuan Provincial People’s Hospital, Dean of Chongqing Women and Children Hospital (Chongqing Maternal and Child Health Hospital), and Qi Hongbo, Chairman-designate of Perinatal Branch of Chinese Medical Association, commented on this achievement.

Academician Qiao Jie pointed out in his comments, "The biggest innovation of this clinical study by Academician Huang Hefeng is to include monogenic diseases in the scope of non-invasive prenatal screening. This progress not only significantly improves the detection rate of fetal genetic diseases, but also provides safer, timely and accurate information for pregnant women and doctors in the decision-making and management of pregnancy, marking an important breakthrough in the field of genetic diseases and birth defects prevention and control."

Academician Yang Zhenglin pointed out in his comments that "the dominant monogenic disease caused by new mutation is the weak link in the current prenatal screening, and it is an inevitable trend for NIPT to include it in the comprehensive screening of fetal cfDNA. The research of Academician Huang Hefeng’s team not only proposed a novel and efficient technical path, but also demonstrated the clinical effectiveness of related technologies, providing important theoretical and practical basis for further improving prenatal diagnosis and prevention and treatment of hereditary birth defects. "

Dean Qi Hongbo pointed out in his comments, "This three-in-one comprehensive screening method has significantly improved the detection rate and demonstrated high accuracy, which proves its great potential in clinical application. If this method can be popularized in clinic, it will effectively fill the gap in prenatal screening for dominant monogenic diseases, which is of great practical significance for improving China’s prenatal screening system and prevention and control of birth defects. "

What is prenatal non-invasive screening?

Noninvasive prenatal screening (NIPS): It is a kind of prenatal screening technology. The screening targets are mainly trisomy 21, trisomy 18 and trisomy 13, which are common fetal chromosomal diseases. After 2013, it quickly integrated into the prenatal screening system and became the most effective and widely used prenatal screening method.

At present, non-invasive prenatal screening (NIPS) detects aneuploidy or microdeletion/microdeletion syndrome by analyzing fetal free DNA(cfDNA) in maternal peripheral blood. Because most of the maternal plasma cfDNA comes from the mother, it is difficult to detect fetal specific variation in high maternal background, and many hereditary diseases can not be detected at present.

What is comprehensive non-invasive prenatal screening technology?

Comprehensive non-invasive prenatal screening (cfDNA comprehensive screening) technology covers three main human genetic variations, namely chromosome aneuploidy, chromosome microdeletion and single gene variation, which expands the detection range of non-invasive prenatal screening and improves the detection accuracy, and is of great significance in the field of prenatal screening.

What did the study find?

The team established a new targeted enrichment method-COATE-SEQ (Figure 1), which realized multi-dimensional analysis of maternal and fetal free DNA, solved many technical defects of the first generation NIPT, and realized non-invasive prenatal detection of fetal chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic disease at the same time for the first time.

Figure 1 New generation NIPS technical process

This study evaluated the clinical effectiveness and increased detection efficiency of this new generation NIPS technology through a multicenter prospective clinical study lasting nearly 2 years.

During the period from April 24th, 2021 to September 10th, 2022, 1191 pregnant women (age ≥20 years, single pregnancy ≥12 weeks, abnormal fetal structure (including NT≥3mm), high risk of NIPT or maternal serological screening, or high risk of genetic diseases due to previous pregnancy history) from three maternity hospitals in different provinces of China were included in the study, and all the participants underwent a comprehensive prenatal cfDNA screening. Finally, the screening results of 1,090 pregnant women who met the criteria for ovulation were analyzed. Pathogenic genetic variation was detected in 135 cases (12.4%) of pregnancy through comprehensive cfDNA screening, which was confirmed by diagnostic tests, including 89 aneuploidies, 9 microdeletions and 37 single gene variations (Figure 2). Compared with the current standard screening for chromosomal abnormalities (NIPT), the detection rate of diagnostic genetic variation in comprehensive cfDNA screening increased by 60.7%, the sensitivity was 98.5% (95% CI, 94.3%-99.7%), and the specificity was 99.3% (95% CI, 98.4%-99.7%).

Figure 2 Detection rate of genetic variation in pregnancy with abnormal fetal structure

Among 876 cases of pregnancy with abnormal fetal structure, 98 cases (11.2%) detected diagnostic gene variation. Among them, 42 cases were autosomal aneuploidy (42.9%), 13 cases were sex aneuploidy (13.3%), 6 cases were microdeletion (6.1%) and 37 cases were single gene (37.8%). B in 876 cases of pregnancy with abnormal fetal structure, the detection rate of diagnostic genetic variation was the highest in lymphatic or hydrops abnormalities (36.9%), followed by skeletal abnormalities (24.7%) and multiple system abnormalities (23.3%). The highest detection rate of chromosomal abnormalities was lymphatic or hydrops abnormalities (32.6%), followed by multiple system abnormalities (19.2%), thickening of the transparent layer behind the neck (8.8%), heart defects (5.7%) and craniofacial abnormalities (5.7%). The highest detection rate of single gene abnormality is skeletal abnormality (23.5%), followed by lymphatic or hydrops abnormality (4.3%), multi-system abnormality (4.1%), FGR(2.9%) and brain developmental abnormality (2.2%).

What is the significance of this research?

Incorporating chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic diseases into fetal cfDNA screening is beneficial to prenatal diagnosis, can be used as an auxiliary tool for early identification in the first trimester of pregnancy, supplement the current imaging-based methods, and is also beneficial to prenatal screening and perinatal management. When pregnant women with abnormal fetus choose to continue pregnancy and refuse invasive surgery, this screening becomes particularly important. Comprehensive NIPS screening can provide more accurate prenatal screening for a wide range of hereditary diseases and provide valuable help for risk assessment and timely management of pregnancy.

Correspondents of this study are Zhejiang University/Director of Key Laboratory of Reproductive Genetics/Academician Huang Hefeng and Researcher Zhang Jinglan of Fudan University, Zhang Dan of Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Xu Chenming of Obstetrics and Gynecology Hospital affiliated to Fudan University and Wang Hua of Hunan Children’s Hospital. The co-first authors are Luo Qiong, the Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Wu Yiting and Chen Songchang, the Obstetrics and Gynecology Hospital affiliated to Fudan University, and Xi Hui, the Maternal and Child Health Hospital of Hunan Province. Chen Yuan, Jiang Ying, Chen Panpan, Liu Yifeng and Dong Min Yue also participated in the study.

It is the eternal pursuit of the development of non-invasive prenatal screening and the long-term research and development goal of the medical community to screen more kinds of important fetal genetic diseases simultaneously with a tube of maternal peripheral blood more accurately and efficiently.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is the leading unit of Zhejiang Prenatal Diagnosis Center, Zhejiang Fetal Medical Diagnosis and Treatment Center, Zhejiang Prenatal Diagnosis (Screening) Quality Control Center, Zhejiang Obstetric Medical Quality Control Center, Zhejiang Critical Pregnant Women Treatment Center, Zhejiang Remote Fetal Heart Monitoring and Interpretation Center, Zhejiang Labor Analgesia Technical Guidance Center, Zhejiang Maternal and Child Nursing Specialist Nurse Training Base and other institutions.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is a national key clinical specialty, a key (supporting) discipline in Zhejiang Province, and the leader unit of Zhejiang perinatal health care cooperation group. The annual delivery volume exceeds 20,000 person-times, among which the high-risk pregnancy exceeds 80%, the proportion of serious, difficult and critical cases exceeds 35%, and the success rate of maternal rescue basically reaches 100%. It has formed sub-specialties such as maternal medicine, fetal medicine and general obstetrics, and opened more than 20 specialty clinics such as fetal medicine clinic, prenatal diagnosis consultation clinic and gestational diabetes clinic. It has a very high rescue success rate for difficult and critical patients such as pregnancy complicated with refractory heart failure, pre-eclampsia critical state, acute fatty liver of pregnancy, amniotic fluid embolism, adult respiratory distress syndrome, severe prenatal hemorrhage and severe postpartum hemorrhage. In the basic and clinical research of pregnancy-induced hypertension, the diagnosis and treatment of intrahepatic cholestasis of pregnancy, the treatment of intrauterine growth retardation, the prognosis evaluation of intrauterine brain diseases and intrauterine kidney diseases, intrauterine fetal surgery such as fetal mirror, delivery room surgery, gestational diabetes mellitus, various fetal intrauterine monitoring, painless delivery and other fields, fruitful results have been achieved; He has accumulated rich clinical experience and management ability in premature delivery, premature rupture of membranes, twins, cervical incompetence, early-onset preeclampsia and early-onset intrahepatic cholestasis of pregnancy. It is an early large-scale unit in China to carry out prenatal diagnosis and fetal monitoring, and has established a prenatal screening system-prenatal diagnosis system-prenatal diagnosis management system.To make a multi-level cross-study on complicated and difficult fetal birth defects.

Source | Zhejiang University Women’s Hospital

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Tesla Model Y suddenly cut the price by10,000! Owner’s rights protection: refund me 10 thousand yuan

  A few days ago, Tesla officially announced that it would order to pick up the car before the end of the year. The final payment of the Model Y rear-drive version and the long-life all-wheel drive version was reduced by 10,000 yuan, and the price started at 239,900 yuan. The sudden price reduction of Tesla Model Y made the old car owners who had just picked up the car dissatisfied, and the car owners once again staged the story of "protecting rights by reducing prices".

Ranger network

  A few days ago, a number of Tesla Model Y owners posted the "Tesla Price Reduction Rights Protection Statement" on the Internet.

Ranger network

  An activist car owner introduced that he ordered a Model Y in Tesla’s official sales channel on November 3, 2024, and successfully paid the full amount of the final payment under the constant urging of sales and delivery personnel. The car was picked up on November 16.

  However, less than ten days after picking up the car, that is, on November 25, Tesla officially announced that it would cut the price of Model Y by 10,000 yuan, which seriously damaged its economic interests.

  The owner introduced that he repeatedly confirmed the price and preferential policies to the sales staff during the car purchase. The other party replied that it was the lowest price after receiving the subsidy, but Tesla’s sudden price reduction made him suffer unnecessary economic losses.

  The rights-defending car owner asked Tesla officials to give him reasonable compensation and explanation, refund 10,000 yuan lost due to price reduction, or provide equivalent compensation such as vehicle upgrade service or extended warranty.

  At present, Tesla has not responded to the demands of rights-defending car owners.

Ranger network

Some edema comes from heart disease? There are many reasons for edema of lower limbs, so we should be vigilant.

  Li yonglei

  For "edema", most people will recognize it. The simplest way is to press the affected area with your hand. If the skin sags into a small pit and cannot recover immediately, it is "swollen". After living at home for more than two months, many middle-aged and elderly people have similar edema. What needs to be vigilant is that the causes of edema are not only the obvious reduction of exercise and the high age of the family, but also some pathological reasons may be hidden.

  Clinically, "edema" generally refers to edema of lower limbs, mainly manifested as swelling of limbs, which starts at the ankle and then spreads to the whole lower limbs, and sometimes occurs in the limbs, but edema of lower limbs is the most common.

  Why does kidney disease cause edema?

  Mr. Ma has always felt weak waist recently, and his urine is dark and frothy. When he took off his socks, he found obvious indentation on his calf. After seeing a doctor, he was diagnosed with hematuria, proteinuria, moderate hypertension and other problems, and was later diagnosed as acute glomerulonephritis. The edema in the patient’s leg is the secondary edema caused by renal disease.

  Edema can be caused by many reasons, and different edema has different characteristics. Edema caused by kidney diseases is called nephrogenic edema. Nephrogenic edema is the most common cause of edema in clinic, and it is also one of the common symptoms of kidney diseases. Why can kidney problems lead to edema? There are two main reasons: first, the filtration function of glomerulus to water and sodium decreases, while the renal tubule reabsorbs water and sodium well, which leads to the retention of water and sodium, which is often accompanied by the increase of capillary permeability in the whole body, so the water in the interstitial space is retained; Second, a large amount of proteinuria in the body leads to low plasma protein.

  Nephrogenic edema first occurs in loose tissues, such as ankles, eyelids or face, which is most obvious in the morning and can spread to lower limbs and the whole body in severe cases. It is characterized by being soft and easy to move, showing concave edema in clinic, that is, depression can occur when pressing local skin with fingers.

  Clinically, nephrogenic edema is mainly divided into nephrotic edema and nephritis edema.

  Nephrotic edema mainly refers to nephrotic syndrome. In addition to systemic edema, patients also have a lot of proteinuria, hypoproteinemia and hyperlipidemia. All causes of nephrotic syndrome, including primary causes (minimal change nephropathy, mesangial proliferative glomerulonephritis, mesangial capillary glomerulonephritis, membranous nephropathy, focal segmental glomerulosclerosis) and secondary causes (allergic purpura, systemic lupus erythematosus, hepatitis B virus-associated nephritis, diabetic nephropathy, renal amyloidosis, myeloma nephropathy) can cause nephrotic edema.

  Nephritis edema mostly starts from eyelid and face, mainly seen in patients with acute glomerulonephritis. In addition to edema and hypertension, the patient’s clinical manifestations are also urine changes, such as hematuria, proteinuria, red blood cell cast, oliguria, etc. After the acute phase, the edema can subside.

  For such patients, early treatment is the key, and the overall treatment principles are as follows:

  1. Restrict sodium salt intake: Both nephrotic edema and nephritis edema have sodium and water retention, so sodium salt intake must be restricted, but it should be appropriate to avoid hyponatremia;

  2, diuresis: when necessary, using diuretics while limiting sodium can promote sodium and water discharge to relieve edema, and can relieve hypertension and reduce heart load;

  3, control proteinuria: proteinuria must be controlled for nephrotic edema, and immunosuppressive drugs (dexamethasone, prednisone, etc.) can be used to restore the normal permeability of glomerulus;

  4, under the guidance of a doctor, supplement plasma protein.

  Some edema comes from heart disease.

  Ms. Liu, 75, has a history of hypertension for many years, but she believes that she is in good health and does not take medicine regularly. After catching a cold two weeks ago, I felt weak, palpitation, obvious swelling of my feet, and it was difficult to wear shoes. After coming to the hospital, he was diagnosed as hypertension, coronary heart disease and heart failure by the Department of Cardiology.

  Ms. Liu, a patient with hypertension, suffered from heart disease and heart failure after catching a cold. It is due to the edema of lung congestion tissue, the increase of airway resistance and the decrease of alveolar elasticity, resulting in dyspnea, which is to say that breathing is fast and shallow. In fact, clinically, most hypertension will be combined with various types of heart disease, and at the same time, different stages of heart disease may be accompanied by different degrees of hypertension. Poor long-term control of hypertension can cause changes in heart structure and function, which is called hypertensive heart disease. Studies have shown that 70% of heart failure is caused by hypertension, and there may be related cardiac complications such as coronary heart disease and atrial fibrillation. In the early days, patients are prone to fatigue dyspnea, such as when going upstairs, carrying loads, buying food, and even when looking after children. Some people will have paroxysmal dyspnea at night, which usually occurs 1-2 hours after falling asleep. Patients wake up because of tightness and shortness of breath, and may have cough and foam-like sputum. Those with mild symptoms can relieve themselves and live as usual during the day, while those with severe symptoms can continue to attack and cough pink foam-like sputum.

  Then, how is edema related to high blood pressure and heart disease?

  Recently, many patients who came to the hospital due to edema of lower limbs were admitted to the clinic, and some of them were diagnosed as cardiogenic edema. Cardiogenic edema is the body edema caused by cardiac dysfunction. The disease can present systemic or localized edema, which first manifests as decreased urine volume, heavy limbs and increased weight, and then gradually appears edema of lower limbs and whole body. Under normal circumstances, the patient’s ankle first appears sunken edema, which gradually develops into systemic edema. Accompanied by right heart failure, patients will also have other symptoms and signs, such as palpitation, asthma, jugular vein distension, hepatomegaly, and even pleural effusion and ascites. The principles of treating cardiogenic edema are cardiotonic, diuretic and heart protection.

  In heart diseases, heart failure is the most common cause of limb edema. Due to the different concentrations of protein and salt in blood and surrounding tissues, when blood circulation is blocked, the surrounding tissues can easily absorb the liquid in blood excessively, resulting in edema. However, leg swelling caused by heart disease develops relatively slowly, and many elderly people only notice the abnormality because their feet are swollen and they can’t wear shoes. Cardiogenic edema of lower limbs does not need deliberate treatment, and the heart function is restored, and the symptoms of edema can naturally be significantly improved.

  Mosquito bites can also cause edema of lower limbs.

  Recently, Mr. Wang was bitten by a bug when he went out for an outing. After scratching his calf wound, he developed redness and edema. He was diagnosed with erysipelas after seeing a doctor.

  Erysipelas is an infection involving superficial lymphatic vessels of dermis, and the main pathogenic bacteria are group A β Streptococcus hemolyticus Any inflammation of the skin, especially the inflammation with chapped or ulcerated skin, can be a way for pathogenic bacteria to invade the human body. Mild abrasions or scratches, injuries outside the head, unclean umbilical cord ligation and chronic leg ulcers may all lead to this disease.

  Infected with erysipelas, why does the lymphatic system have edema?

  Lymphatic system is a resource recovery and antivirus system of human body, which is widely distributed in human body. Lymphogenic edema mainly refers to the proliferation of subcutaneous fibrous connective tissue after repeated infection of soft tissue fluid on the body surface caused by the obstruction of lymph reflux in some parts of the body. If limbs are involved, it will be thickened, and the skin will be thickened, rough and tough like elephant skin in the later stage, also known as "elephant skin swelling".

  Lymphatic dysplasia or infection can cause swelling of tissues in the corresponding area. There are also some people who have slight abnormalities in the development of blood vessels in their lower limbs and are more prone to edema symptoms. We usually analyze the condition of patients’ lymphatic system by puncturing subcutaneous edema tissue fluid. The protein content of lymphedema fluid is usually very high, ranging from 1.0 to 5.5g/dl, while the protein content of edema tissue fluid with simple venous stasis, heart failure or hypoproteinemia is 0.1 to 0.9g/dl. However, this method can’t understand the lesion site and function of lymphatic vessels, and it is necessary to determine the development or obstruction of lymphatic vessels by lymphangiography.

  Thromboedema of cardiac vein in patients with low back pain

  Mr. Liu is obese, has irregular meals and stays up late for a long time. He is a lover of carbonated drinks and has a history of lumbar muscle strain and lumbar disc herniation. In recent days, he suffered from swelling and pain in his unilateral calf, which was obvious after sitting and standing, but did not relieve obviously after lying in bed. After examination by a doctor, deep venous thrombosis has formed in his lower limbs.

  Seeing the doctor’s diagnosis, Mr. Liu was puzzled and felt that the thrombus came suddenly. Actually, it is not. He is obese, does little exercise, stays up late, and has an unreasonable diet. These factors will easily lead to an increase in blood viscosity. In addition, he suffers from waist disease, and will stay in bed and take medicine when the pain attacks. Staying in bed for a long time will make the blood flow slow, the muscles will not pump enough blood, and it is easy to form a thrombus. At the same time, although taking medicine relieved waist inflammation, it also concealed other symptoms, thus delaying the opportunity to see a doctor. Therefore, we remind patients with lumbar diseases to pay attention to the phenomenon of edema in limbs.

  Venous thromboedema is common after surgery, trauma, long-term bed rest and long-term desk workers. The vast majority of venous thrombosis of lower limbs is painful first and then swollen, and the more swollen it is, the more painful it is. The most common harm of this disease to human body is pulmonary embolism caused by blood clots falling off, which leads to death. Some blood clots may also cause cerebral thrombosis, renal thrombosis and intestinal thrombosis. The degree of harm mainly depends on the proportion of blood vessel blockage and the shape of thrombus. After regular anticoagulation and anti-inflammatory treatment, a considerable number of patients’ conditions can be stable, and regular medication can be taken later. For those with serious blood vessel blockage and the risk of thrombus falling off, timely surgery is needed. At present, the implantation of inferior vena cava filter is the main method to prevent fatal pulmonary embolism caused by thrombus shedding in acute stage, and it is a minimally invasive operation by interventional method. If thrombus is ablated after anticoagulant therapy, surgery can be avoided; If the patient has persistent high fever, sepsis, uncontrollable infection and irreversible necrosis of lower limbs, it may be necessary to consider amputation.

  Generally speaking, there are many reasons for edema of lower limbs, which cannot be enumerated here. For healthy people, we suggest that you do the following three things in your daily life to avoid edema as much as possible. First, exercise moderately, avoid sitting and lying for a long time, and pay attention to moving the lower limbs when flying for a long time; The second is to supplement water properly and eat fruits and vegetables reasonably to avoid blood viscosity; Third, those who suffer from physical injuries due to diseases or various reasons, and need to use anti-inflammatory and anticoagulant drugs for prevention under the guidance of professional doctors, should follow the doctor’s advice and take drugs correctly.

  (Author: Beijing Longfu Hospital)

Many people around us have been recruited, so we must pay attention to this disease.

Original Xu Chao, I’m Chaoski.

Now that the flu is in an epidemic period, many people around me have confessed. I don’t know what the situation is like there.

According to the monitoring data of the National Influenza Center, the percentage of influenza-like cases in the total number of outpatient and emergency cases in southern and northern provinces increased compared with the previous week, which was also significantly higher than the same period last year.

Further analysis shows that the current wave of influenza viruses in the south and north are mainly influenza A virus H3N2 subtype.

Today, I will talk to you seriously about the related problems of swine flu. I hope you can do a good job of protection and avoid being recruited.

Influenza A (A) virus is a kind of influenza virus. According to the two proteins on the surface of influenza A virus, namely hemagglutinin (HA/H) and neuraminidase (Na/N), it can be divided into different subtypes. Among them, there are 18 H subtypes (H1-H18) and 11 N subtypes (N1-N11).

Three major H subtypes (H1, H2 and H3) and two N subtypes (N1 and N2) have been reported in humans. Influenza A virus subtypes commonly prevalent in humans include influenza A H1N1 and influenza A H3N2. Influenza A is the only influenza virus known to cause a global influenza pandemic.

Seasonal influenza is mainly caused by influenza A (H1N1), H3N2 and influenza B virus infection.

It is mainly transmitted by droplets of respiratory secretions, direct or indirect contact and fine particles. The incubation period after infection is usually 1-3 days.

The typical clinical features after infection are acute onset, high fever, headache, muscle aches, fatigue and mild respiratory symptoms.

Body temperature often reaches its peak in several hours to 24 hours, reaching 39-40℃, even higher or accompanied by cold, and may also be accompanied by respiratory symptoms such as dry cough, stuffy nose and runny nose.

Some patients may be accompanied by conjunctival congestion, retrosternal discomfort and gastrointestinal symptoms such as vomiting, abdominal pain, diarrhea or constipation.

If there are no complications, the course of the disease is mostly self-limited. After 3-4 days, the body temperature will gradually subside and the general symptoms will improve, but it may take 1-2 weeks for cough and fatigue to recover.

If it is severe influenza, the disease progresses rapidly, mainly manifested as pneumonia, acute respiratory distress syndrome, acute kidney injury, septic shock and multiple organ dysfunction syndrome.

Among them, pneumonia is the most common complication of influenza, which can be divided into influenza virus pneumonia, secondary bacterial pneumonia or mixed pneumonia. It usually appears after 2-4 days, or the condition improves briefly after treatment, and symptoms such as fever, cough, cough with thick phlegm, and difficulty breathing reappear.

We used to hear family members in media reports say, "Isn’t it just a cold? When people came, they were fine. How could they die?" Yes, the flu is also possible.

For patients with chronic underlying diseases (such as heart failure, myocardial infarction, stroke, diabetes, chronic obstructive pulmonary disease, asthma, liver and kidney dysfunction), the situation may be more dangerous. Some data show that compared with healthy people of the same age, patients with chronic basic diseases are more seriously ill after being infected with influenza virus, and the risk of death is 11.3 times that of healthy people.

There are two kinds of drugs commonly used in influenza. One is antipyretics, such as ibuprofen and acetaminophen. The other is anti-influenza drugs.

At present, the antiviral treatment of influenza is relatively mature, including neuraminidase inhibitors (such as oseltamivir), hemagglutinin inhibitors (such as Abidor) and RNA polymerase inhibitors (such as mabaloxavir). For emergency patients with non-severe influenza, antiviral treatment should be carried out in time after etiological diagnosis. For emergency patients with severe and critical influenza, antiviral treatment should be started within 48 hours of onset, without waiting for the result of etiological diagnosis.

Most cases of infection with H1N1 are mild. Besides the antipyretic and antiviral treatment mentioned above, symptomatic treatment can also be carried out:

1. If there is an acute cough related to influenza, antihistamines (such as diphenhydramine) and expectorants (such as acetylcysteine and carbomestane) can be added to relieve the cough;

2. If there is acute diarrhea related to influenza, you can use oral rehydration salts, fully rehydrate, supplement intestinal probiotics, and use montmorillonite powder;

3. If there is an acute sore throat related to influenza, you can use some buccal tablets and atomized inhalation. Many people have experienced "blade throat" before, and I believe they should have some experience.

Another point is the flu vaccine. I remind everyone to get the flu vaccine almost every autumn and winter, especially children, the elderly, patients with chronic diseases and other people with high risk of flu, and pay more attention to daily protection.

Generally speaking, after 2-4 weeks of influenza vaccination, the human body will produce antibodies with protective level. Some people may ask, is it too late to get vaccinated now? How to say, as long as you can get the flu vaccine, it is recommended to get it as soon as possible to prevent subsequent infections.

Ok ~ today’s issue is more serious. Thank you for seeing the friends here. I hope everyone can protect themselves and their families and be healthy ~

Reference: The consensus of emergency experts on the diagnosis and treatment of adult influenza (2022 edition)

Disclaimer: Some pictures are from the Internet. If there is any infringement, please contact to delete them.

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Expert’s comment on the film "The Bitter-tongued Lawyer": Touching the "Pain Point" of Reality


Original title: Touching the "pain point" of reality and reaching the "cool point" of the public — — A Review of The Bitter-tongued Lawyer


Wen Yi Yin Hong (film critic, vice chairman of China Film Association)


Special feature of 1905 film network It tells the story of lawyer Lin Liangshui, a single mother who is deeply involved in the abuse of women, fighting back against the powerful Jedi and defending the final dignity of the law.


The film’s release in the mainland has aroused widespread concern. First, it has created the highest box office record in the history of Chinese films in Hong Kong, China, breaking through the pattern of Hollywood films dominating the Hong Kong market in recent years; Secondly, it is a legal drama that is different from the popular types of Hong Kong movies, such as martial arts, police and bandits, action and gangs. Literary drama movies can become the most popular movies, which shows its unique value and charm. Thirdly, this is a breakthrough work by a well-known "talk show" actor in Cantonese. Its success has made many expecters get their wishes, and strangers have made new discoveries.


As a Chinese-language film set in Hong Kong’s society, law, life and characters, The Poisonous Mouth Lawyer will inevitably have some so-called "cultural discounts" and "cross-cultural losses" when it is shown in the Mainland, but its vivid characterization, accurate narrative rhythm, smooth image presentation and full comedy texture, especially its shouting for social fairness and justice, will certainly arouse the mainland audience’s recognition of the film stories and characters.



The courage of "literary drama" lies in the characters. The uniqueness, freshness and vividness of the characters should be the premise for the film to gain the recognition of the audience. Legal themes are not uncommon in Hong Kong film and television dramas. But in this film, Lin Liangshui, a barrister played by Wong Tze Wah, is different from those well-dressed and domineering lawyers. On the one hand, he is arrogant, on the other hand, he is cynical. At the beginning of the film, the comic and exaggerated court judgment, which was delayed, made his character’s personality take the lead. However, in the vicious judgment speech, there was a sharp hatred and discrimination, which laid the foundation for the subsequent transformation.


When Lin Liangshui, like other lawyers, tried to praise the "smelly feet" of the rich and enjoy the worldly life of being drunk, he did not expect to be kicked to the ground by the "smelly feet" and sent an innocent woman to prison by mistake. On the one hand, it is the torture of conscience, on the other hand, it is also the humiliation of self-esteem. Lin Liangshui has to cross the rubicon and fight back, thus winning the final "face" for himself and the law. This character is gradually injected with the motivation of individual behavior from a low starting point, which is similar to the narrative strategy of Song Youshuo, a Korean film-making lawyer who was all the rage that year. This image, from defect to height, from waste to hero, has successfully completed the image of a lawyer who is unruly but still has a conscience and righteousness.


It is this tension that makes the characters grow and change radian, and has the fireworks of life and the diversity of personality. At the same time, it also brings a sense of life interest and comedy that the audience can easily accept and get close to. At the same time, Lin Liangshui’s dramatic conflict with other characters also had a solid foundation, and Jin Yuanshan, as his opponent in the prosecution and defense, finally had the condition of "turning around" under the inspiration of the bottom line of justice. Affinity, vividness, motivation coherence and transformation arc together constitute the narrative charm of characters.



Of course, the biggest reason why this work can become a "best-selling film" is that it sharply touches on the common topic of society: social justice represented by legal justice. Zeng Jieer, a former model in the film, became a victim of self-protection in the rich circle in an accidental misfortune, from a "doll" to an "insulted and damaged" helpless and helpless victim woman. Although this story is not new, it can be said that it has given new meaning to the "old topic" in the current social ideological trend of paying attention to social fairness and justice after the great development of globalization and capitalization.


More and more people feel the explicit and invisible social privilege brought by the expansion of power, and even become legal privilege. People’s dissatisfaction with this kind of social privilege, hierarchical solidification and huge inequality under superficial equality has been seen frequently in recent years’ film and television works such as Clown, Parasite and Squid Game. At this point, The Poisonous Tongue Lawyer can be said to have touched the common pain point of public concern.



If only the "pain point" is revealed, The Bitter Lawyer is still a film with limited audience and serious social issues. In fact, this film is a genre film that brings excitement to the audience with its "cool point". As a legal drama, there are many court debates in the film, but these debates are not only the inquiry and defense of the case, but also the questioning of social inequality, the accusation of legal injustice and the condemnation of human injustice. These sharp, sharp and cold statements, although not necessarily in line with the possibility of debating the real scene in court, make the film climax again and again, and the audience is surging with emotion.


The climax of the whole film is Lin Liangshui’s roar at the final trial: "In the past, everyone said that everyone was equal before the law; Nowadays, everyone has changed his mind and said that the poor are dead before the law. I will see who will die today. " In the end, the "just" ending of the prosecutor’s lawyer’s rebellion, the plaintiff’s becoming the defendant and the jury’s great reversal filled the audience with the pleasure of victory. In this sense, the film is a "legal" film that lets the audience vent and be happy. It leads the audience to get a "fair" satisfaction with an "unfair" incident.



In the audio-visual presentation, the film maintains the modern rhythm of the film and some comic exaggerations with fast and smooth editing, but it insists on the zero degree of "words only" in artistic style, without intentional spectacle display, luxurious big scenes and even plain camera language.


Although the choice of this film style may be related to cost control, it also fully shows that the audio-visual presentation of the film serves the story, the characters, the emotions and the theme. Showing off your skills is sometimes necessary, but it is not necessarily necessary. As the producer of the film said, the most fundamental thing of the film is to tell a good story.



Of course, as mentioned above, The Poisonous Lawyer is a highly completed commercial genre film, and the genre film’s "routines" constitute the underlying logic of its story. The long-standing comedy style of Hong Kong films adds "kindness" to its "serious" theme, and many scenes of the court are also rendered without the "real possibility" genre.


Therefore, judging "The Poisonous Lawyer" by serious realistic film standards, obviously we can find a series of so-called "slots". However, if we regard it as a legal film that touches the "pain point" of society and releases the "cool point" of public psychology, we may not be entangled in the boundary between "reality" and "fiction". It is a kind of "hypothesis", which brings the audience a collective carnival to scream for fairness and justice.

New film viewpoint

Special fund support for national film industry


China’s vaccine transportation capacity is sufficient, and more than 7,700 transportation orders have been issued to ensure the efficient transportation of more than 1.6 million vaccine preparations.

  Cctv newsOn May 27th, the Ministry of Transport held a regular press conference in May to release the overall situation of the development plan of the maritime system in the 14th Five-Year Plan and answer questions from reporters.

  Sun Wenjian, spokesman of the Ministry of Transport, said at the meeting that with the extensive vaccination work in COVID-19, the task of transporting vaccine goods is becoming increasingly heavy. In particular, the epidemic situation in some areas has been sporadic recently, and the demand and willingness for vaccination have risen again. In order to do a good job in the organization and service guarantee of vaccine cargo transportation, the Ministry of Transport has taken five measures:

  The first is to carry out transportation capacity and promote the docking of transportation supply and demand.The Ministry of Transport issued a list of 56 key logistics enterprises to promote the close connection between vaccine production enterprises and logistics enterprises. Generally speaking, the top 30 pharmaceutical logistics enterprises have nearly 8,000 refrigerated trucks and nearly 300,000 refrigerated incubators, which can meet the transportation demand as a whole.

  Second, close departmental coordination and strengthen transportation service guarantee.The Ministry of Transport, in conjunction with the public security, health, civil aviation, drug administration, China State Railway Group Co.,Ltd. and other departments and units, issued a notice to make overall arrangements for the docking of supply and demand, vehicle traffic protection, transportation process supervision, personnel safety education, risk prevention and information traceability.

  The third is to strengthen technical guidelines and standardize loading and unloading operations.In conjunction with the health care, customs, drug administration and other departments, the Technical Guide for Road Transportation of Vaccine Goods in Covid-19 was issued, which urged and guided all localities and relevant enterprises to strictly implement the technical requirements in all aspects of vaccine goods transportation, such as preparation, transportation process and emergency response, and standardized various operations.

  The fourth is to establish a waybill system and implement free passage of vehicles.The Ministry of Transport has opened account numbers for Covid-19 vaccine manufacturers such as Sinopharm and Kexing and 32 provincial CDC, and implemented the policy of free, non-stop and priority access for vehicles with transportation orders. Up to now, China’s vaccine cargo transportation capacity is sufficient, running smoothly, and more than 7,700 transportation orders have been issued, ensuring the efficient transportation of more than 1.6 million vaccine preparations.

  The fifth is to insist on one thing and one discussion to ensure the smooth transportation of vaccines.The Ministry of Transport announced the duty telephone number 010-65292831 for the guarantee of vaccine cargo transportation, implemented 7×24-hour duty, unblocked transportation coordination channels, coordinated and handled one thing at a time, and accepted and solved more than 310 vaccine cargo transportation matters.

  Sun Wenjian finally said that in the next step, the Ministry of Transport will continue to focus on the key points of work, focusing on ensuring smooth flow and capacity, close departmental coordination, strengthening overall scheduling, and strengthening on-duty duty duty to provide a solid transportation service guarantee for vaccine production, supply and vaccination.

Six advantages make Biden stand out.

Topic: 2008 US Presidential Election


Senator Biden, wearing sunglasses, is more mature and sophisticated.


  (Reporter Li Mingbo) Senior Senator Biden eventually became Obama’s running mate, which benefited from his rich diplomatic experience and high fighting spirit when confronting the Republican Party.


  Obama once said that he wanted a deputy who could challenge his ideas, but now he finally got what he wanted. Biden is the ideal candidate for his deputy.


  Advantage 1: Make up for Obama’s diplomatic weakness


  Biden is the chairman of the Senate Foreign Relations Committee, and he is familiar with many world leaders and diplomats. In addition, he is familiar with foreign policies and international security affairs. Last weekend, he received an invitation from the President of Georgia to visit Georgia in the middle of his visit to Russia. During the period of tense relations between the two countries, he could run between Russia and Georgia, fully demonstrating his diplomatic influence.


  In Washington, Biden is regarded as an academic figure, but his words are sharp immediately after he gives warm praise. Because McCain has repeatedly attacked Obama for his lack of foreign policy experience, Biden can make up for Obama’s weakness in diplomacy.


  Democratic Party adviser McMahon said, "I think he is to Obama what lyndon johnson is to John F. Kennedy. He has superb diplomatic skills and a senior and outstanding Senate background. He is one of Obama’s most effective agents at present, because he can compete with Republican opponents at any time and on any issue.


  Advantage 2: Life is bumpy and has affinity.


  Although Biden is from Delaware, he was born in Pennsylvania and is a devout Catholic. Biden’s Catholic background can help Obama consolidate the ballot box. In addition, Biden is also very popular among Jews, which is his advantage.


  Another advantage of Biden is his personality charm. Biden’s wife and two young daughters were killed in a traffic accident. The battered Biden once intended to quit politics, but finally decided to continue his political career. At that time, Biden was sworn in by his son’s hospital bed, and he still stopped work for one day on the day of the car accident (December 18) to send his grief.


  After decades, he went home by train almost every day to meet his family. This remarkable life experience made him have a strong affinity.


  Advantage 3: Congress has been familiar with the operation for 35 years.


  Biden, 65, has been working in Washington since 1972. Years in Washington gave him a good understanding of the city and the operation of Congress, which Obama lacked.


  Just as Cheney helped George W. Bush when he ran for office in 2000. At that time, Bush was inexperienced in politics, but he persuaded Cheney to advise him and finally won.


  Advantage 4: It is difficult to have an idea about the presidency.


  Biden’s experience is enough to help him a lot in foreign policy, so that Obama can devote more energy to developing the economy.


  More importantly, at the age of 65, Biden doesn’t seem to have any thoughts about the presidency. So for Obama, Biden’s political relationship with himself should be much simpler than the relationship between other presidents and their vice presidents.


  Advantage 5: Being born in a working family and accepting a variety of votes.


  Biden was born in an ordinary working-class family in scranton, Pennsylvania. He has a good relationship with trade unions and appeals to blue-collar workers.


  Obama did not perform as well as Hillary in winning the support of this class in the primary stage. Perhaps Biden, who is white, can help Obama attract more blue-collar white voters.


  Advantage 6: Resolutely oppose crime.


  Republicans have accused Obama of being weak in cracking down on domestic crimes, which may affect Obama’s impression among white voters. Biden happens to have a good performance in opposing crime, and his joining will undoubtedly reverse this impression disadvantage.


  It was Biden who led the drafting of the violent crime control law in 1994. According to this law, more than 100,000 policemen took to the streets to patrol, which greatly reduced the occurrence of street criminal cases in the United States.


  Three major disadvantagesnot to be neglected


  Disadvantage 1:


  Washington’s old face


    Image or drag


  Obama’s campaign slogan is "change", and he promised to bring change to the United States in the primary election. This slogan finally helped the young Obama to defeat Hillary Clinton, who is experienced in politics, in the democratic primary election. But Biden, who has worked in Congress for 35 years, can be said to be an old courtier in Washington. This image of Biden may be a drag on Obama. It remains to be seen whether Americans who like innovation and change will accept such old faces.


  Disadvantage 2:


  Lack of administrative experience


  Both Obama and Biden are senators. Biden has been a senator for six consecutive terms, and Obama has not finished one term. However, both of them lack experience in administration, which gives people the feeling that they have some shortcomings in their abilities.


  Disadvantage 3:


  Attacked Obama.


  Habitual duplicity?


  Earlier this week, the American media revealed a final list of four people, and Biden was the number one favorite.


  However, just two days ago, Biden told reporters who were stuck in front of his house: "I’m not that person." In fact, Biden already knew that he was Obama’s running mate. Biden’s untrue remarks triggered criticism from the American media. Some people questioned: Is he very good at lying?


  Coincidentally, shortly after Obama officially confirmed Biden, the McCain campaign released a media interview recording. In this interview in 2007, Biden attacked Obama’s foreign policy and said that "he is not the ideal candidate for the president". In early 2008, Biden told reporters after withdrawing from the primary election that he would not be vice president for anyone, and he would rather continue to choose to be chairman of the Senate Foreign Relations Committee.


 


Related links:



  • Focus on Obama’s deputy Biden: a heavyweight expert in foreign affairs August 23, 2008
  • Six advantages make Biden stand out. August 24, 2008
  • There is a great hope that O ‘Byrne will enter the White House, and there are still variables. August 24, 2008
  • Moderate "Dove" Biden advocates contact rather than confrontation. August 24, 2008
  • Biden was chosen as Obama’s deputy. August 24, 2008
  • Obama abandoned "male and female matching" and chose "young and old matching" August 24, 2008
  • News Person: Biden, US Democratic Vice Presidential Candidate August 23, 2008
  • Biden: From stutterer to speaker August 24, 2008

Editor: Zhang Renhe

Russia’s withdrawal of all military bases in Georgia has not eased relations between the two countries.

     

    [Content at a glance]Russia’s 62nd military base in Georgia entered a military state [data photo] On November 15th, a senior Russian military official revealed that Russia had withdrawn all its troops in Georgia, so far, all Russian military bases in Georgia have been closed. Georgian President Saakashvili accused a large number of Russian heavy weapons and personnel of illegally entering Abkhazia in recent days, and they did not belong to the peacekeeping force.


  



Russia’s 62 nd military base in Georgia entered a military state [data picture]


Senior Russian military officials revealed on November 15 that Russia has withdrawn all its troops stationed in Georgia, so far, all Russian military bases in Georgia have been closed. Although the garrison problem that has long caused friction between the two countries has been solved, the recent tension between the two sides has not eased.


Russian troops bid farewell to Georgia


According to Russian media reports, Russian Army Commander Alexei? Maslov said on the 15th: "There are no Russian troops in Georgia, leaving only peacekeepers, some in Abkhazia and some in South Ossetia."


After the disintegration of the former Soviet Union, Russia retained four military bases in Georgia. As of June this year, except for the 12th military base in Batumi, the capital of the Republic of Azar, Georgia, the other three bases have been officially handed over to the Georgian government, and the Russian military’s foreign Caucasus cluster command in Tbilisi, the capital of Georgia, was also closed at the end of last year.


According to the withdrawal agreement signed by Russia and Georgia in March last year, Russian troops should completely withdraw from their military bases in Batumi before October 2008. The evacuation was one year ahead of schedule. Russia and Georgia completed the relevant handover procedures on the 13th, and the last Russian base in Georgia will be officially handed over to the Georgian Ministry of Defence on December 1st.


Transfer to Armenian base


According to Colonel Konashenkov, press assistant to the commander-in-chief of the Russian Army, the last military special train used for the evacuation of Batumi military base contained 34 cars and other military technical equipment with a total weight of about 200 tons, and Major General popov, commander of the Russian Caucasian Cluster Command abroad, and 150 troops were also evacuated with the train. They entered the territory of the Republic of Armenia in the early morning of 15th, and will arrive at No.102 Russian military base in Gyumri in northern Asia on the evening of 15th.


Armenia is Russia’s strategic partner in Transcaucasia, and the military and political relations between the two countries are very close. At the Gyumri base, the Russian army deployed more than 100 tanks and about 300 armored personnel carriers, as well as artillery systems, various air defense missile systems and more than 4,000 officers and men. Its task was to cover the southern wing of Russia and protect Armenia. Armenia not only does not charge Russia for the use of the base, but also provides it with related equipment and maintenance services.


In addition to the Gyumri base, there are five Russian military bases in the "brother" countries of the Commonwealth of Independent States, namely the Aini base in Tajikistan, the Kantor air base in Kyrgyzstan, the Sevastopol naval base in Ukraine, the Baranovich early warning radar station in Belarus and the Daryal early warning radar station in Azerbaijan. With the adjustment of military strategy and the change of military strength, Russian military bases abroad gradually lost their pure military color and played a more important political role.


Relations between the two countries remain tense.


Although Russia fulfilled its promise to remove its military base from Georgia one year ahead of schedule, Russian political scientists believe that this will not help much to improve the tense relations between the two countries. Alexander, an expert at the Russian Post-Soviet Space Social and Political Process Research Center? Karavayev said: "This move should ease the relationship between the two countries, but this has not happened."


Leonid, director of the Russian Geopolitical Research Institute? Ivashov agrees with this view. At the same time, he believes that it is necessary to strengthen the military presence in Abkhazia and even the southern Federal District to make up for the military vacuum caused by Russia’s withdrawal of military bases from Georgia. "Now we need to strengthen the Russian peacekeeping forces in Abkhazia and ensure their safety, because the conflict between Georgia and the unrecognized Republic of Abkhazia may escalate."


However, two political scientists also admitted that the loss of the military base in Georgia did not cause much loss to Russia’s strategic plan.


At present, Abkhazia and South Ossetia, where Russian peacekeeping troops are stationed, are Georgia’s autonomous republics and autonomous prefectures, respectively, bordering Russia. After the disintegration of the former Soviet Union, they declared their independence and have been in a state of confrontation with the Georgian central government, but they both maintain close relations with Russia. As a result, Georgia and Russia are at loggerheads over Abkhazia and South Ossetia.


Georgian President Saakashvili accused a large number of Russian heavy weapons and personnel of illegally entering Abkhazia in recent days, and they did not belong to the peacekeeping force. This was categorically denied by the Russian side, calling this statement "a pure lie" and a provocation against Russia. (China Daily website/Kang Juan)


  



Russian military officials announced the early completion of their withdrawal from Georgia.


Colonel Igor Konashenkov, Press Assistant to the Commander-in-Chief of the Russian Army, said on the 15th that the special train carrying Russian soldiers and materials from the 12th military base in Batumi, Georgia, had arrived at the border between Armenia and Georgia at 14: 00 Moscow time. Read the full text ""


Russian experts: Russian military forces are in danger and unable to defend the country.


According to the report "Counting Putin: Crisis and Decline of Russian Army" by Russian National Institute of Strategic Studies, Russian military forces are at the most dangerous moment, especially during Putin’s administration, and this situation has an irreversible trend in Putin’s era. Read the full text ""

Editor: Cao Jin