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Decision of the People’s Government of Inner Mongolia Autonomous Region on Abolishing Some Government Regulations

The Decision of the People’s Government of Inner Mongolia Autonomous Region on Abolishing Some Government Regulations, which was adopted at the 23rd executive meeting of the People’s Government of the Autonomous Region on November 17, 2021, is hereby promulgated and shall come into force as of the date of promulgation.

Wang Lixia, Chairman of the Autonomous Region

November 25, 2021

Inner Mongolia Autonomous Region People’s GovernmentDecision on Abolishing Some Government Regulations

In order to maintain the unity of the socialist legal system, the 23rd executive meeting of the People’s Government of the Autonomous Region on November 17, 2021 discussed and passed, and decided to abolish the following government regulations:

1. Measures for the Implementation of Regulations on Kindergarten Management in Inner Mongolia Autonomous Region (promulgated by Decree No.14 of the People’s Government of Inner Mongolia Autonomous Region on November 10, 1990 and amended by Decree No.175 of the People’s Government of Inner Mongolia Autonomous Region on November 26, 2010);

2. Measures for the Implementation of the Regulations on Salt Industry Management in Inner Mongolia Autonomous Region (promulgated by Decree No.21 of the People’s Government of Inner Mongolia Autonomous Region on December 18, 1990, revised by Decree No.87 of the People’s Government of Inner Mongolia Autonomous Region on August 13, 1998, and revised by Decree No.175 of the People’s Government of Inner Mongolia Autonomous Region on November 26, 2010);

3. Measures for the Implementation of Urban Water Conservation Management in Inner Mongolia Autonomous Region (promulgated by Decree No.23 of the People’s Government of Inner Mongolia Autonomous Region on February 23, 1991 and amended by Decree No.175 of the People’s Government of Inner Mongolia Autonomous Region on November 26, 2010);

4. Measures for the Implementation of the Regulations on School Physical Education in Inner Mongolia Autonomous Region (promulgated by Decree No.41 of the People’s Government of Inner Mongolia Autonomous Region on June 11, 1992 and revised by DecreeNo. 115th of the People’s Government of Inner Mongolia Autonomous Region on October 11, 2001);

5. Detailed Rules for the Implementation of the Law on Guarding State Secrets in Inner Mongolia Autonomous Region (promulgated by Decree No.55 of the People’s Government of Inner Mongolia Autonomous Region on January 3, 1994, and amended by Decree No.175 of the People’s Government of Inner Mongolia Autonomous Region on November 26, 2010);　　

6. Regulations on Quality Supervision and Management of Construction Projects in Inner Mongolia Autonomous Region (promulgated by Decree No.57 of the People’s Government of Inner Mongolia Autonomous Region on April 7, 1994, revised by Decree No.87 of the People’s Government of Inner Mongolia Autonomous Region on August 13, 1998 and revised by Decree No.175 of the People’s Government of Inner Mongolia Autonomous Region on November 26, 2010);

Seven, "the Inner Mongolia Autonomous Region mineral resources compensation fee collection and management implementation measures" (promulgated by Decree No.59 of the Inner Mongolia Autonomous Region People’s Government on June 29, 1994, revised by Decree No.87 of the Inner Mongolia Autonomous Region People’s Government on August 13, 1998, and revised by Decree No.175 of the Inner Mongolia Autonomous Region People’s Government on November 26, 2010);

Eight, "the Inner Mongolia Autonomous Region in violation of mine safety regulations and fines" (promulgated by DecreeNo. 60th of the People’s Government of Inner Mongolia Autonomous Region on September 19, 1994, revised according to DecreeNo. 175th of the People’s Government of Inner Mongolia Autonomous Region on November 26, 2010);

9. Measures for the Administration of Product Standards in Inner Mongolia Autonomous Region (promulgated by Decree No.69 of the People’s Government of Inner Mongolia Autonomous Region on May 8, 1996, revised by Decree No.95 of the People’s Government of Inner Mongolia Autonomous Region on December 28, 1998 and revised by Decree No.175 of the People’s Government of Inner Mongolia Autonomous Region on November 26, 2010);

Ten, "the Inner Mongolia Autonomous Region major and extraordinarily serious fire accident responsibility investigation and handling regulations" (DecreeNo. eighty-fifth of the Inner Mongolia Autonomous Region People’s Government on July 20, 1998);

Eleven, "the Inner Mongolia Autonomous Region administrative punishment hearing procedures" (promulgated by DecreeNo. ninetieth of the Inner Mongolia Autonomous Region People’s Government on October 29, 1998, and revised according to DecreeNo. 175th of the Inner Mongolia Autonomous Region People’s Government on November 26, 2010);

Twelve, "the Inner Mongolia Autonomous Region to investigate and deal with acts of counterfeiting patents" (promulgated by Decree No.89 of the Inner Mongolia Autonomous Region People’s Government on October 29, 1998, and amended by Decree No.175 of the Inner Mongolia Autonomous Region People’s Government on November 26, 2010);

Thirteen, "the decision of the Inner Mongolia Autonomous Region People’s Government on comprehensively promoting administration according to law" (DecreeNo. 100th of the Inner Mongolia Autonomous Region People’s Government on December 9, 1999);

Fourteen, "the Inner Mongolia Autonomous Region premarital medical examination management measures" (DecreeNo. 103rd of the Inner Mongolia Autonomous Region People’s Government on February 24, 2000);

15. Measures for the Administration of Brokers in Inner Mongolia Autonomous Region (promulgated by DecreeNo. 125th of the People’s Government of Inner Mongolia Autonomous Region on January 24, 2003);

Sixteen, "the Inner Mongolia Autonomous Region according to the proportion of employment arrangements for the disabled" (DecreeNo. 140th of the Inner Mongolia Autonomous Region People’s Government on December 27, 2005);

17. Measures for the Implementation of Farmland Occupation Tax in Inner Mongolia Autonomous Region (promulgated by DecreeNo. 158th of the People’s Government of Inner Mongolia Autonomous Region on May 30, 2008, and revised by DecreeNo. 204th of the People’s Government of Inner Mongolia Autonomous Region on November 18, 2014);

Eighteen, "the Inner Mongolia Autonomous Region People’s governments at all levels of fire safety responsibility system" (DecreeNo. 161st of the Inner Mongolia Autonomous Region People’s Government on December 22, 2008);

XIX. Administrative Measures for Environmental Protection of Urban Catering and Entertainment Services in Inner Mongolia Autonomous Region (promulgated by Decree No.164 of the People’s Government of Inner Mongolia Autonomous Region on January 13, 2009, revised by Decree No.219 of the People’s Government of Inner Mongolia Autonomous Region on May 10, 2016 and revised by Decree No.230 of the People’s Government of Inner Mongolia Autonomous Region on January 16, 2018);

20. Measures for the Administration of Grain Circulation in Inner Mongolia Autonomous Region (promulgated by DecreeNo. 165th of the People’s Government of Inner Mongolia Autonomous Region on February 10, 2009 and revised by DecreeNo. 230th of the People’s Government of Inner Mongolia Autonomous Region on January 16, 2018);

Twenty-one, "Measures for Promoting Informatization in Inner Mongolia Autonomous Region" (promulgated by DecreeNo. 169th of the People’s Government of Inner Mongolia Autonomous Region on January 27, 2010);

22. Measures for the Administration of Copyright in Inner Mongolia Autonomous Region (promulgated by DecreeNo. 171st of the People’s Government of Inner Mongolia Autonomous Region on May 25, 2010);

Twenty-three, "the Inner Mongolia Autonomous Region new rural and pastoral cooperative medical management measures" (DecreeNo. 194th of the Inner Mongolia Autonomous Region People’s Government on February 20, 2013);

24. Measures for the Administration of Public Credit Information in Inner Mongolia Autonomous Region (promulgated by Decree No.234 of the People’s Government of Inner Mongolia Autonomous Region on June 13, 2018).

This decision shall come into force as of the date of promulgation.

Country Garden is flat!

In August,It is exposed that the company is caught in liquidity difficulties and enters a state of "quasi-default";

In September,During the grace period of one month, Country Garden stepped on the line to pay the overdue US dollar debt coupon, temporarily avoiding default;

In October,That is, yesterday, Country Garden announced that the cash situation is still under pressure and will start overseas debt restructuring.

Reorganize,That is, housing enterprises cannot pay their debts on time.You need to roll over the debt to get some breathing space.

According to the existing statistics, Country Garden currently has 15 US dollar bonds in existence, involving a principal of about 9.3 billion US dollars. There is no principal due in 23 years, and there are 2 in 24 years.

The interest due this year is mainly the dollar debt bill, which means that Country Garden can’t afford the debt interest now.

To make an announcement is to tell everyone that they are going to lie flat.

Or Country Garden already knows that there is no chance to turn over. Instead of struggling, it is better to lie flat.

After all, people’s memories are still there.

For example, Lao Yang passed the position to Xiao Yang in order to get away with it.

For another example, Xiao Yang donated 20% of the shares of Country Garden Service in his hand, totaling 6.4 billion to Guoqiang Public Welfare Foundation for the development of charity, which is a typical transfer of high-quality assets.

Just like Evergrande, there is nothing to analyze.

Next, Country Garden can strive for a long debt restructuring cycle as long as it guarantees the delivery of the building according to the wishes of the top management.

During this period, Country Garden can make many adjustments to save itself. Just like Evergrande, it can still be delayed for two or three years after the thunderstorm.

However, if Country Garden keeps stepping on the red line like Evergrande, it will be hard to say.

According to the news reported by the media today, at the recent monthly meeting of Country Garden, Mo Bin, the president with an annual income of over 100 million yuan last year, explained the donation of shares in Yang Huiyan, revealed that the boss had sold his private jet, and excused himself by the way.

Share donation has already started, with the purpose of public welfare, but the timing is not good.Executives did earn some money a few years ago, but now their annual salary has been reduced to a minimum. The annual salary of themselves and Dr. Cheng has been reduced to 3 million and 1 million.

Let’s not say whether this explanation is useful or not, but we can see that the Evergrande incident did shock some people, but the degree of shock is hard to say.

But it doesn’t matter what Country Garden said. It’s only a matter of time before it falls.

In the first nine months of this year, Country Garden realized equity sales of 154.98 billion yuan, down 43.9% year-on-year, and down 65.4% compared with 2021.

Looking at it every month,In January, the sales of Country Garden was still 22 billion yuan, which fell to 12 billion yuan in July and 6.17 billion yuan in September.Compared with the average monthly sales of more than 40 billion in the peak period, it is just two words, which is sluggish.

So, why are Yang and Yang preparing for the thunderstorm? Because of the real sales situation of Country Garden, they know it too well.

And it’s really hard to turn things around.

More than 60% of the properties for sale in Country Garden are in third-and fourth-tier cities. It is a foregone conclusion that house prices in third-and fourth-tier cities will fall. What is waiting for Country Garden in the future isIf we get rid of difficulties and continue to lose money, asset valuation will continue to shrink.

In addition, in the case of public default and undiminished debts, whether it is first-and second-tier real estate or third-and fourth-tier real estate, the sales end will face a devastating plunge.

This is the vicious circle of public debt default thunder.

In other words, the real challenges and pressures of Country Garden are still behind.

This is obvious and invisible on the surface, as well as the tremendous pressure brought by foreign exchange fluctuations, and the "borrowing the new and returning the old" can’t go on.

In August, Country Garden issued an announcement summarizing that one of the reasons for the loss was the expected net exchange loss caused by foreign exchange fluctuations.

To put it simply, the domestic sales rebate is RMB, and the overseas repayment is US dollars. There is an exchange rate problem.

In the past, the interest rate of the US dollar was low. In the past two years, the Federal Reserve continued to raise interest rates, and the interest rate of the US debt was close to 6%. At the same time, the RMB was also in a weak state, and the floating profit had long since become a floating loss.

It means that it may be six dollars when you borrow it, but you have to pay seven dollars when you return it. Not only did you not pay less, but you also had to pay more.

According to the published data, in 2022, Country Garden lost 8.4 billion yuan and Evergrande lost 9.6 billion yuan because of the exchange rate.

In addition, the interest rate of American debt continues to rise, and "borrowing the new and returning the old" can no longer be played.

After the deleveraging of domestic real estate, many real estate enterprises ran abroad to borrow US dollar debt because they could not get money from banks. Originally, it was quite good and smooth, but after the interest rate of American debt continued to rise, the financing cost became higher and higher, and the road of borrowing new and returning old was blocked.

Country Garden is notoriously afraid to borrow money. Before that, the former chief financial officer of Country Garden wrote a book, which told me to spend 1000 days in Country Garden, revealing many details of Country Garden’s borrowing money. Because the content was too true, it was blocked by President Yang.

It mentioned that President Yang borrowed GLD, and also mentioned that President Yang gambled with international capital. In short, the interest rolled up to several hundred million, but the money it actually earned was not enough.

With more debts, I thought about desperately taking land and developing quickly, but with a large scale, the operation will no longer be fine. In the current market, there is no suspense in the outcome. Country Garden in the first half of this yearThe assets are 1.62 trillion, and the liabilities are 1.36 trillion.More than half of the assets are projects under construction and properties for sale.

Country Garden has made the same mistake as Evergrande today.

What is the ending of Country Garden? Is it the next Evergrande? Or the next Sunac?

This is not difficult to answer. Like Evergrande, it is impossible to rescue directly with invisible hands, because the financial burden cannot be borne, and we can only look at the market.

The market of the third and fourth lines is already established. What are we looking at?

To sum up, there are two points:

1. Can the price be greatly reduced, and the price will be exchanged for the amount, which will pull back the blood;

2. Whether it is possible to realize the massive blood transfusion of financial institutions.

At present, these two points are unrealistic.

1、Recently, Huizhou’s 50% discount on selling houses has been stopped. This is not the first time that a place has stopped selling houses at a discount.

2、Financial institutions should be responsible for their own profits and losses, at their own risk, and giving blood transfusion to housing enterprises like Country Garden is tantamount to beating dogs with meat buns.

Therefore, the end of the next Country Garden, including many private housing enterprises that have already gone out of danger, has been decided. Now I hope that the Baojiao Building that everyone has vowed to shout out can really fall.

Current statistics on Country Garden:

The house that hasn’t been handed in yet,There are about 600 billion, which is more than 600 thousand families according to 1 million suites, but the reality is definitely more than that;

Money owed to suppliers,There are about 300-400 billion;

Money owed to financial institutions,There are about 260 billion.

For the ending of Country Garden, you can also express your views in the comment area ~

At 7: 30 every Friday night, Cherry will give a special closed-door live class for WeChat users, with different topics, and answer questions with fans.If you want to listen to the closed-door live class on Friday night, remember to add that WeChat will receive a push once a week.

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My personal direct and bold point of view will be sent to the following WeChat official account, so please pay attention to it.

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Chongqing Museum of Natural History will open the first treasure warehouse.

The newly restored giant panda specimen. (Photo courtesy of Chongqing Natural Museum)

May 18th is "World Museum Day". In order to celebrate the festival of this global museum, Chongqing Natural Museum will open its treasures warehouse to the public for the first time free of charge. On that day, visitors can walk into the 340-square-meter warehouse and watch more than 1,200 precious specimens from all over the world at close range. Members of the public can pay attention to the reservation activities of WeChat WeChat official account in Chongqing Natural Museum.

On May 14th, with the approval of the Natural History Museum, the reporter went into the warehouse in advance to inquire about this special "animal world" for readers.

"Unlike fossil specimens, there are no ancient creatures in the treasure warehouse, but all living animals. Among them are not only giant pandas, golden monkeys, South China tigers, but also rare albino black bears in nature." Zhao Liwei, the collection manager of the collection management department of the Natural Museum, said that some of these specimens came from the old collections in the museum, some from the collection of specimens, and some from the donation of the Bellin Foundation.

Two panda specimens made their debut.

In the vast warehouse, more than 1,200 animal specimens are placed on a three-storey specimen rack in different categories. Some of them have been "living" in the warehouse for decades, and some have just "moved" into the warehouse.

Among them, the latest "check in" are two giant panda specimens. These two giant panda specimens have just been restored by a professional restoration team. Before they were made into specimens, they were the old panda skin specimens in the museum.

Is it difficult to "stand up" the panda skin specimen?

Zhao Liwei said that there is a very difficult link in specimen restoration, that is, to present the specimen with the most natural posture of the animal before its death.

"In order to restore these two giant panda specimens, the restoration experts not only watched various videos of giant pandas repeatedly, but also made a special trip to the zoo to record the movements and expressions of giant pandas at close range." Zhao Liwei said that unlike the giant panda cultural and creative products, the specimen restoration will never adopt the posture that people like but the giant panda itself can’t make. "That is to say, their restored posture is a common state of giant pandas in nature."

So, what is the giant panda that was finally restored? A prone on the rocks, side face spit out the pink small tongue; The other one sat on the ground and gave a grin with his head tilted.

As the oldest natural museum in southwest China, there are several giant panda specimens in the treasures warehouse of Chongqing Natural Museum, which are prone or standing, showing different postures.

Rare albino black bear specimens are hiding in it.

In addition to all kinds of giant panda specimens, there is also an albino black bear specimen in the treasure room, which is also the old collection of Chongqing Natural Museum.

In order to let the audience appreciate this specimen better in the coming open day of the warehouse, the collection manager gave it a "black and white match"-a black bear specimen was placed next to the albino black bear.

Zhao Liwei said that in nature, the phenomenon of albinism of black bears is relatively rare, and albino black bears that can be made into specimens are even rarer.

What exactly is the albino black bear specimen like?

From a distance, it looks like a miniature polar bear. Its front left palm is slightly raised, and its whole body leans forward slightly, as if it is slowly moving forward.

At present, the recorded cases of albino bears are very rare. In 1950s, local residents in Shennongjia, Hubei Province hunted an albino bear. This albino bear in Shennongjia was identified as an albino species of Asian black bear, which was also the earliest case of albino bear found in modern China. In 2000, there were also traces of albino black bears in Shennongjia.

It is understood that albinism exists widely in all kinds of vertebrates, but it is rare. Usually, melanin cannot be synthesized normally in animals due to gene mutation, which makes it appear white, yellow-white or light yellow in external form.

See more head and shoulder specimens donated by the Behring Foundation.

In addition to all kinds of animal specimens placed on the specimen rack, there is a special wall with dozens of head and shoulder specimens hanging on it in the treasure warehouse.

Most of these head and shoulder specimens belong to Cervidae, and they were donated to the Natural Museum by the Bellin Foundation in batches.

Visitors who have been to the Natural History Museum know that there is a Belling Hall on the first floor of the museum.

Since April 2011, kenneth e behring, a world-famous philanthropist, the founder and chairman of the Global Health and Education Foundation and an honorary citizen of Chongqing, has visited Chongqing seven times in succession.

During this period, the old man donated 325 wild animal specimens worth more than $30 million to Chongqing Natural Museum, which together formed the Bellin Hall-Animal Planet Exhibition in the museum. The audience can see nearly 300 rare wild animal specimens here. They are various and lifelike, which can be called a trip to the global animal carnival.

But this is not all the specimens donated by Bellin, because the exhibition hall area is limited, and some duplicate specimens are collected in the treasure warehouse, which also means that the audience can see more wild animal specimens donated by Bellin in the warehouse.

New Chongqing-Chongqing Daily reporter Li Sheng

China Consumers Association named KFC： Using ＂blind boxes＂ to induce excessive food consumption, when boycotting.

On January 12th, China Consumers Association published an article in official website, saying that recently, KFC and POP MART, a blind box seller, jointly launched the "DIMOO joint-brand blind box package", which caused consumers to snap up and aroused widespread concern in society. According to the sales rules of this blind box package, if you want to collect the whole set of dolls, you need to buy at least 6 packages, and the probability of rare hidden models is 1:72. To this end, some consumers will not hesitate to spend 10494 yuan to buy 106 packages at one time; There are also consumers who buy the "substitute food" service for "begging for a baby", hire someone to buy the set meal for them and get a blind box, and even do not rule out throwing away the food that can’t be eaten directly.

China Consumers Association said that in commodity sales, fancy promotion methods such as buying gifts, points, discounts and red envelopes emerged one after another. As long as it is reasonable and legal, the normal profit-making promotion not only increases the sales volume of the merchants, but also benefits the consumers, which is understandable. However, KFC, as a catering enterprise, deals in fast food for limited use, which is characterized by instant consumption on demand. Usually, consumers will not over-purchase, while the sale of limited-edition blind boxes is a means of "hunger marketing" to stimulate consumption, which easily leads consumers to impulse consumption in order to obtain limited-edition blind boxes, and leads to unnecessary food waste due to over-purchase. KFC, as a food operator, uses limited blind box sales to induce and condone consumers to buy food packages irrationally, which is contrary to public order and good customs and the spirit of law.

Can you carry the banner to test SAIC Volkswagen Huiang 380TSI？

● Power and chassis: 2.0T+7, using MLB platform.

　　This test is equipped with the third generation EA888 2.0T, which is matched with the 7-speed G (wet) powershift. This power system is also its star product. The maximum engine horsepower is 224 HP /4500-6250rpm, and the peak value is 350 Nm /1500-4500rpm.

SAIC Volkswagen Huiang 2016 380TSI Basic Model

SAIC Volkswagen Huiang 2016 380TSI DSG Basic Model

　　Although I look forward to the performance of the 3.0 model as much as everyone else, to be fair, the main sales force of Huiang in China market in the future will definitely be the 2.0T model, and the former has more significance just to prop up the facade of this flagship model.

SAIC Volkswagen Huiang 2016 380TSI DSG Basic Model

　　In terms of chassis, Huiang adopted MLB platform, so the engine was changed to vertical layout. However, the 380 model we tested only adopted a new drive form. According to the news we obtained before, all 3.0 supercharged models will be equipped with four-wheel drive systems. The first five links and the rear trapezoidal link are adopted, and the model tested this time is not equipped with DCC variable suspension system.

● Driving experience: calm and comfortable

　　Just like almost all Volkswagen models I have driven before, Huiang doesn’t need a long time for people and cars, and it can be easily controlled. When I first came into contact with Huiang, I felt very similar to my own Passat. After all, these two models are mainly administrative and business-oriented, and the whole vehicle adjustment is obviously comfortable.

SAIC Volkswagen Huiang 2016 380TSI Basic Model

　　With linear throttle response, moderate steering wheel feedback and soft suspension damping, Huiang can create quite excellent driving quality, which can be summed up in a rotten but easy-to-understand word: solid. I’m sorry I really can’t think of a more appropriate description than this word, but it’s true.

SAIC Volkswagen Huiang 2016 380TSI Basic Model

　　Although the 2.0T engine sounds less exciting than the 3.0L supercharge, it can bring a brisk acceleration feeling in any speed range. The throttle response in D gear mode will be slightly dull, which is estimated to be an adjustment made to take care of passengers’ comfort. After stepping on the accelerator deeply, the downshift is positive, which is consistent with DSG’s consistent performance. In addition, the shift movement at low speed is also quite gentle, which can be compared with the manual transmission.

SAIC Volkswagen Huiang 2016 380TSI Basic Model

　　When it is shifted to S gear, the usual split personality phenomenon of the public has not been reflected much in Hui Ang. The only difference with D gear is that the opportunity to shift gears is greatly delayed. After all, the maximum power speed range of this engine is not low, and the driving computer will maintain the speed above 3000rpm, so that each throttle can urge the vehicle to run forward quickly. But … Hui Ang, flying on the road, doesn’t seem to be in tune with its steady aura.

SAIC Volkswagen Huiang 2016 380TSI Basic Model

　　The feedback of Huiang steering wheel keeps the clear road sense of Volkswagen models, and it is not as if there is a thick sponge between the car body and the road like the new models. As for whether this adjustment is good or bad, it really varies from person to person. Personally, I still prefer this setting. After all, accurate steering and powerful steering wheel feedback can make me feel more practical.

SAIC Volkswagen Huiang 2016 380TSI Basic Model

　　I believe many friends are also curious about the difference in driving experience between Huiang and Passat. In fact, I began to ponder how to describe this car when I got it, but it is really difficult to express it figuratively. If Passat gives me the impression that it is "easy to drive" and "comfortable", then Huiang not only retains the gene of "easy to drive" but also has a great improvement in comfort. The spacious interior space, excellent sound insulation, comfortable seats and properly adjusted suspension system can make Huiang have a great leap in sensory quality. The accumulation of advantages can always achieve the effect of 1+1 > 2, which may explain why Huiang is far superior to his fellow brothers in driving experience.

SAIC Volkswagen Huiang 2016 380TSI Basic Model

　　On the whole, Hui ‘ang has basically nothing to be picky about in driving and riding. The driving experience is steady, the power is brisk, and the excellent riding comfort created by various factors has not sacrificed a certain sense of road, and the overall performance is more balanced. It’s just that our test model is not equipped with DCC. As for whether it can be optional, we are not clear at present. If this system can be blessed, it will perform better.

Besides Tom cruise, why is Mission Impossible 5 worth watching？

Opera assassination in honor of Hitchcock

??1905 movie network news It has been almost 20 years since the first film was released, and it has become a classic spy action series in the hearts of fans. When the fifth film, produced by Paramount and invested by 1905 Pictures and Alibaba Pictures, was released in China this week, word of mouth exploded instantly, and critics and audiences commented on the film one after another: besides Tom cruise, there was a new heroine who could "save the hero with beauty", and the series also experienced the wonders of the fourth film, the drama of the third film and the violence of the second film, and finally returned to the coldness and violence of the first film.

Which bridges are impressive?

Turandot became angry with assassination, tribute and reversal, and the strongest spy girl.

Apart from Tom cruise’s crazy action of plane-scraping and 6-and-a-half-minute anaerobic diving, what the domestic audience praised most was the film’s end-to-end tribute to the classic and retro tone, which made this Hollywood commercial action blockbuster instantly improve its artistic force. The film critic Da Qi said in Weibo that from Ethan’s listening to the task instructions on vinyl records to the fighting assassination of the Vienna Opera House, they all paid tribute to the concert hall assassination drama that was the finale of Hitchcock’s man who knew too much in 1956, and took the rhythm of Turandot’s aria and music score as the soundtrack of the action drama, which was mysterious, assassination and suspense … … These completely different elements are all mixed together to boil the audience’s emotions to the boiling point.

The tone of the film returns to the classic retro style of spy films.

The film critic, The Night Knight, was also impressed by the street fighting at the end. "Using the contrast of light and shade to create a sense of tension and excitement, retro shooting techniques inject new ideas into it", returning to London’s cold and spy film classics. The film critic murdered the TV set and commented on it in the column of "Shadow Target": "I appreciate this pursuit of trying to find a certain balance between classical style and modern blockbusters. In the current Hollywood movies, MI5 is a prominent work."

Rebecca, the new "spy girl", looks like ingrid bergman, the goddess who is also from Sweden.

In addition, almost all the viewers who have seen Mission Impossible 5 can’t forget the outstanding performance of this "Mission Impossible Girl" Rebecca Ferguson. Tao Taolinlin, a well-known film critic, thinks that "the most wonderful part of Disc 5 is that it brings a heroine who is not a vase and can fight. She has dedicated many wonderful fights and action scenes, and even the final battle was completed by her, especially the part of the dress with beautiful legs is really handsome!" In 1874, it also said, "This is a feminist victory. This time, the heroine is no longer a vase that can only flirt in all kinds of spy films, but a spy who will really save the soup from the hot water." This unique setting of "beauty saves the hero" also makes the film different from the boring routine of fighting between strong men and strong women in traditional action movies, not to mention Rebecca, who is also from Sweden, has a classical romantic style like ingrid bergman — — From the English drama "White Queen" to the strongest spy girl, she only used a pair of beautiful legs.

It’s true that Tom stole the plane, it’s true, it’s true (the important thing is said three times)

What is the advantage of Mission Impossible 5 over other spy films??

007 British retro, bourne lone wolf, speed and passion racing.

Magasa, a well-known film critic, wrote in Iris magazine: "What is the unique style of Mission Impossible series? I think it is the pursuit of completing a series of difficult action dramas in an increasingly spectacular space. All the plots and characters exist to provide conditions for the difficult action dramas to play. The speed is getting faster and higher, and the height is getting higher and higher. Tom Cruise jumps over skyscrapers all over the world, dives, brags, and even crashes the plane. I won’t be surprised if he goes into space. "

The scene of motorcycle chase is bursting with speed.

There is no denying that Tom, who is over 50 years old, is still telling the world what madness is with his own demonstration, and he is risking all his life just to please the audience. Compared with other spy movies, a major feature of Mission Impossible series is the thrilling scene of Tom’s life. However, this film has been filmed for nearly 20 years, and when it comes to the fifth film, it is by no means limited to this. Mission Impossible 5 not only maintains the spectacular features of this series, but also incorporates the Bond-style British retro and film noir temperament. After reading it, many viewers said that "the cold war, disc theft, alley fighting, cold humor, and the quality of the series is quite high, which is almost 007". However, Tom cruise, who has always loved racing, had a smooth motorcycle chase in Casablanca, and netizen Chen Xiaoming praised that "the sense of speed was directly abused"

In addition, the most difference from the "lone wolf" lone hero is that Tom is not fighting alone! Even if you are desperate, even with all kinds of black technology, "impossible to complete the task" depends on collective wisdom and teamwork. Simon pegg, who loves to gag, Jeremy Renner, who is hard to tell the difference between loyalty and treachery, and Rebecca Ferguson, who is a "black widow", "The netizen’s shadow expressed affectionately:" In the fifth part of Mission Impossible series, appreciate each other, who is also an agent, can already be seen, and the tenderness of "one person, no one of the same kind" is beyond luck. From the first movie, I have been running and running to the old Tom, which is touching. I can’t think of any other way, but I have to do something for my friends, right?’ "This may be the soft place that the Mission Impossible series can touch everyone’s heart most.

Attention! The latest release of Shaanxi CDC

　　Today (June 1), Shaanxi Provincial Center for Disease Control and Prevention issued a health reminder for June, especially reminding people to pay attention to novel coronavirus infection, hand, foot and mouth disease, epidemic hemorrhagic fever, brucellosis, rabies, respiratory infectious diseases and food-borne diseases.

　　First, novel coronavirus infection

　　As of early May, XBB series mutants have become the main epidemic strains in Covid-19, China. Compared with the early epidemic branches in Omicron, the pathogenicity of XBB series mutants has not changed significantly. It is suggested that people should continue to do personal protection and health management.

　　Health tips

　　(1) It is suggested that those who meet the requirements should be vaccinated with Covid-19 vaccine as soon as possible without any contraindications. The target population of vaccination at this stage is: ① people who are not infected and have not completed the established immunization program. Including uninfected people aged 3-17 who have not completed basic immunization, uninfected people aged over 18 who have not completed the first dose of booster immunization, and uninfected people aged over 18 who have not completed the second dose of booster immunization; ② People who have been infected and have not completed basic immunization.

　　(2) Do a good job in daily protection. Wear masks scientifically, pay attention to hygiene habits, wash hands frequently, pay attention to cough etiquette, gather less, open windows regularly at home and workplace for ventilation, and do a good job in daily hygiene in the room.

　　(3) Strengthen personal health management. Pay close attention to your family and your own health every day. If you have symptoms such as fever, dry cough, fatigue, sore throat, decreased sense of smell, diarrhea, etc., avoid going to school or work with illness, and go to a fever clinic in a nearby hospital as appropriate. Wear a mask all the way to the hospital and try to avoid taking public transport.

　　(4) Once infected with Covid-19, it is recommended not to go out unless necessary, to avoid going to crowded public places, not to participate in gathering activities, and to wear masks all the time. During the period of living at home, infected people should reduce close contact with their roommates, do a good job in self-health monitoring, and see a doctor in time if necessary.

　　Second, hand, foot and mouth disease

　　Hand, foot and mouth disease (HFMD) is a common infectious disease in children caused by enterovirus infection, mostly in children under 5 years old. The monitoring data over the years show that April-July is the main epidemic season of hand, foot and mouth disease in Shaanxi, and it has entered a high incidence period.

Attention! The latest release of Shaanxi CDC

　　Health tips

　　(1) Vaccination with EV71 vaccine can effectively prevent hand, foot and mouth disease caused by EV71 virus and effectively reduce the risk of severe illness and death.

　　(2) Pay attention to hand hygiene, especially before touching the nose and mouth, before meals, after defecation, or after going out and going home, after touching herpes/respiratory secretions, after changing diapers or handling articles contaminated by feces, wash your hands with flowing clean water+hand sanitizer or soap to guide children to master the "seven-step washing method".

　　(3) Pay attention to ventilation, and open the window for ventilation 2-3 times a day. During the epidemic of hand, foot and mouth disease, try to avoid taking children to places where people gather and the air circulation is poor.

　　(4) Always change and dry clothes, bedding, towels and diapers; Clean and disinfect toys, personal hygiene utensils, tableware and other items every day.

　　(5) Pay attention to the health status of children. Once there is fever, rash (especially perianal rash) or oral ulcer, go to medical institutions in time. Delayed treatment or misdiagnosis may easily lead to the development of children into severe cases and even lead to death.

　　(6) Nursery institutions should strictly implement measures such as morning and afternoon check-up, absence from class due to illness, epidemic report, ventilation and disinfection, etc., report sick children in isolation in time, and do a good job in the discovery, response and disposal of aggregated and outbreak epidemics.

　　Iii. Epidemic hemorrhagic fever

　　Hemorrhagic fever is a natural epidemic disease caused by Hantavirus, with rodents as the main source of infection, and the incidence rate is high among farmers who often work or have activities in the field. In the recent summer harvest season, outdoor activities and field work have increased the chances of contact with rodents and their pollutants. It is recommended that the masses do a good job in protection.

　　Health tips

　　(1) Vaccination is the most important and effective measure to prevent hemorrhagic fever. Vaccination should be carried out in time and in the whole process according to relevant vaccination requirements.

　　(2) Strengthen personal protection and develop good hygiene habits. Try to avoid contact with rats and their excreta pollutants, and don’t stay overnight in outdoor places such as orchards to prevent mites from biting; Rodent control measures can be implemented for a long time in key places such as villages, orchards, vegetable gardens and farms.

　　(3) Do not eat cold food, water, etc., especially those contaminated by rodents; Wear masks, hats and gloves when cleaning up messy things and wastes (such as straw and corn stalks).

　　(4) In case of fever, muscle soreness, skin bleeding and other symptoms, you should go to the hospital in time.

　　Fourth, brucellosis

　　Brucellosis (brucellosis for short), also known as lazy disease, is a zoonotic infectious disease caused by brucellosis. Sheep, cattle and pigs suffering from brucellosis are the main sources of brucellosis in human beings, and it is clinically characterized by long-term fever, sweating, fatigue, joint pain, hepatosplenomegaly and lymphadenopathy.

　　Health tips

　　(1) Buy sheep from a regular sheep farm without brucellosis epidemic, and conduct quarantine and immunization on the sheep regularly.

　　(2) Livestock should be kept in captivity, separated from humans and animals, avoiding water sources, and not scattered and mixed.

　　(3) Occupational people engaged in livestock breeding, fur and milk meat processing, veterinarians, etc., should take personal protection in the process of occupational contact such as breeding, wear work clothes, masks, rubber gloves and other protective articles, and do not directly contact with sick livestock products. At the same time, Ying Qin should wash hands and disinfect, change clothes, maintain environmental hygiene, and conduct regular physical examination, and treat suspicious symptoms in time.

　　(4) Pay attention to food safety, do not drink raw milk or eat raw meat, and separate raw and cooked chopping boards when cooking.

　　Five, rabies

　　Summer is the high incidence of dog injuries. The sultry weather can easily make dogs fidgety and impulsive. At the same time, people wear thin clothes in summer and are easily bitten and scratched by dogs.

Attention! The latest release of Shaanxi CDC

　　Health tips

　　(1) Scientifically manage pets. Families who keep pets should apply for dog registration certificate, vaccinate their pets in time, and keep their pets in captivity, and don’t abandon them at will.

　　(2) When walking dogs, dog chains, muzzle covers and dog cages should be used to control the range of activities and behaviors of dogs and avoid the occurrence of dog injuries.

　　(3) Avoid contact with wild animals and stray animals, do not tease and play with cats, dogs and other animals, do not disturb dogs that are eating, sleeping or caring for their cubs, and do not let animals lick skin wounds.

　　(4) After being bitten by dogs, cats and other animals, you should go to the nearby standardized dog injury treatment clinic as soon as possible.

　　(5) In contrast, children are more dangerous to be bitten. The bitten wound is deep and serious, and the closer it is to the head, neck, face and hands, the more dangerous it is, which requires special attention. It is necessary to strictly wash the wound, inject immunoglobulin, choose more efficient vaccine and vaccinate according to the procedure.

　　Six, respiratory infectious diseases

　　June is still the high incidence season of respiratory infectious diseases such as mumps, scarlet fever, chickenpox, rubella and measles, and schools and kindergartens should be alert to the outbreak of the epidemic.

　　Health tips

　　(1) Vaccinate infectious diseases such as measles, chickenpox, mumps, etc. which are prevented by vaccines in time and in the whole process according to relevant vaccination requirements.

　　(2) Pay attention to good personal hygiene habits, wash your hands frequently, cover your nose and mouth with paper towels when sneezing and coughing, and do not touch your eyes, mouth and nose with your hands. Wash and dry clothes and bedding frequently.

　　(3) Open the window regularly for ventilation several times every day to keep the indoor air fresh.

　　(4) Try to avoid going to crowded places, wear a mask when there are symptoms such as fever, sore throat and cough, and reduce contact with others.

　　(5) Schools and child care institutions should focus on preventing small-scale outbreaks of respiratory infectious diseases, strengthen environmental sanitation and ventilation and disinfection of classrooms in schools, and implement measures such as morning and afternoon inspection, absenteeism registration and epidemic report.

　　Seven, food-borne diseases

　　The weather is getting hotter and hotter, and the rising temperature creates conditions for the proliferation of bacteria, food is more prone to decay and deterioration, and food-borne diseases have also entered a high incidence period.

　　Health tips

　　(1) Develop good personal hygiene habits, wash your hands before and after meals, after touching dirty things and before processing and making food, and disinfect tableware regularly.

　　(2) canteens and families should strictly control the quality of food, and must not buy spoiled poultry, eggs, meat and aquatic products for the sake of greed.

　　(3) Pay attention to kitchen and food hygiene, and separate raw and cooked chopping boards when cooking; Do not eat food that is not thoroughly cooked, and do not drink unclean raw water; Eat as much food as possible, eat little or no leftovers, and put them in the refrigerator if there are any leftovers. When eating out, you must pay attention to choosing a regular restaurant or restaurant with good sanitary conditions.

　　(4) Pay attention to insects and rats indoors, and strengthen the sanitary management of feces, garbage and sewage.

　　(5) If there are symptoms such as diarrhea, fever, abdominal pain and bloody stool, you should go to the hospital in time.

　　one

　　Source: Shaanxi CDC

　　Editor | Long Yi

　　Edit | He Ye

[Editor in charge:

]

Announcement of competitive consultation on digital scanning service of archives (secondary)

Project overview

Entrusted, we organized competitive consultation on [350122]YCGC[CS]2025002-1 and digital scanning service of archives (secondary), and now welcome domestic qualified suppliers to attend. The potential supplier of digital archives scanning service (secondary) should apply for an account at Fujian Provincial Government Procurement Network (zfcg.czt.fujian.gov.cn) for free, and obtain procurement documents by project in Fujian Provincial Government Procurement Online Public Information System, and submit the response documents before (Beijing time).

I. Basic information of the project

Project number: [350122]YCGC[CS]2025002-1

Project Name: Archives Digital Scanning Service (Secondary)

Procurement method: competitive negotiation

Budget amount: 395,000.00 yuan

Second, the applicant’s qualification requirements:

Third, the government procurement policies that need to be implemented in procurement projects

Imported products:Not applicable to this project.

Energy-saving products:Not applicable to this project.

Environmental labeling products:Not applicable to this project.

Fourth, obtain the procurement documents

Time: from to (the provision period shall not be less than 5 working days from the date of this announcement), from morning to afternoon every day (Beijing time, except legal holidays).

Location:

Mode:

Price: free of charge

V. Submission of response documents

Deadline: (Beijing time) (not less than 10 days from the date when the consultation document is issued to the date when the supplier submits the first response document).

Location:

Six, open

Time: (Beijing time)

Location:

Seven, the announcement period

Working days from the date of this announcement.

VIII. Other Supplementary Matters

9. Please contact us in the following ways for inquiries about this tender.

Fujian Yuncheng engineering management co., ltd

May 15, 2025

Advanced compulsory course of fruit powder

Lead:

Apple’s new product launch in September every year is a grand ceremony that every fruit powder is looking forward to, and the corresponding topics will also occupy the headlines of major scientific and technological media. What’s special this year is that the newly released iPhone 6s keeps the 16GB version, because there is little storage space left for users after installing the system and application in the previous generation of mobile phones, so the unexpected result has become a hot topic in the network recently. Also facing the problem of storage space are Mac computers. If you want to choose a model with large capacity, the purchase cost will double. Qunhui Technology, which has the reputation of "Apple in NAS", has developed a more convenient and economical data storage solution for Apple users.

Smart devices, led by iPhone, have accelerated the arrival of the digital age, resulting in changes that users use their mobile phones to connect to the Internet to upload and download a large amount of data every day. The 16GB version has experienced six years of wind and rain. Nowadays, in the face of hundreds of megabytes of applications, it is often difficult to download, not to mention saving photos, listening to lossless music, watching HD videos, and even uninstalling the software to make enough space before the system upgrade.

If you are using a 16GB iPhone, the traditional solution is:

"Save food and use" style, diligently clean up the Application cache, selectively install the app, and avoid installing large games. Although photos, music and videos can be stored in the cloud to save local iPhone space, the news of Yanzhaomen is heard from time to time, and the privacy of cloud space is worrying.

Local style, throw away 16GB to buy 128GB version, I believe few people do this.

Compared with traditional imperfect solutions, Qunhui NAS solutions are smarter. Let’s take Qunhui NAS DS215j as an example to introduce how to solve the problem of iPhone space expansion.

DS215j is chosen as an example, because it is not only an entry-level product with high value, and its price is lower than that required for upgrading the iPhone to 128GB capacity, but the storage space and convenience provided by DS215j are far greater than the latter.

DS215j has dual-core CPU, 512 MB DDR3 memory, and two hard disk slots that can support up to 16TB of storage space. It is equipped with a powerful DSM 5.2 operating system, and with the App software carefully developed by Qunhui for iPhone and iPad, such as DS file, DS video and DS audio, it can solve the troubles caused by the lack of iPhone space more intelligently.

DS file centralized file management

DS215j has the advantage of large capacity, which allows you to store documents in NAS centrally, without worrying about taking up iPhone storage space because of too large documents. No matter personal documents or work files, as long as you log in to DS215j through GroupM QuickConnect on DS file, you can view documents and create links wherever you are. Even gigabyte files can be easily shared with friends directly on iPhone.

DS video exclusive video library

In daily life, watching videos and movies is a basic requirement. Through DS video, you can manage and watch the video content in NAS, regardless of American TV series, movies and documentaries, which can meet the use requirements to the maximum extent. You can watch online without downloading to local storage space. In addition, fruit powder can also use DS video to push movies to TV, and iPhone is the most convenient remote control.

In addition, iPhone or iPad has many playback restrictions, such as not being able to play videos in MKV and RMVB formats. Qunhui Play series models-DS 214 Play and DS415play are equipped with hardware transcoding engines, which can convert videos that were not supported by the original iOS device into compatible formats, so that fruit powder can watch MKV and other videos with 1080p image quality smoothly online.

DS audio will carry it through without loss.

If you are a lossless lover, DS215j is undoubtedly your essential weapon. 16TB space can store tens of thousands of lossless music, and DS audio can also provide you with more personalized music audition experience.

DS photo high privacy cloud photo album

Many fruit powders are most proud of the quality of the iPhone camera, but high-quality photos mean that the phone needs more space. DS photo is equipped with automatic photo backup function, which can automatically back up photos to the NAS at home, so there is no need to worry about the lack of storage space on iPhone.

NAS helps OS X cross-platform file sharing

And another brother of the Apple family, the Mac series computer, although it has a simple and beautiful system and gorgeous appearance, you still need to share files with other operating systems in your life. Because of the different sharing mechanisms between different systems, it is difficult to share files, which affects the experience. For example, when you write data to an NTFS format USB flash drive, you are prompted that the operation cannot be completed; When you set up the shared file, the Windows system computer can’t find it, and vice versa. Faced with the above problems, the traditional solutions are:

Install third-party software

The search results will tell you that certain software can read and write NTFS, and the result of the experiment is that it takes a lot of time and has the defect of insufficient stability.

A setup tutorial that is too complicated to be frightened.

Windows file sharing mechanism is very different from OS X, and setting up the tutorial is cumbersome and

The threshold requirement is high, which makes ordinary users discouraged.

Qunhui NAS DS215j is equipped with excellent DSM operating system. With an intuitive and easy-to-use Web management interface, it can provide a barrier-free and smart way for Mac to share files. You only need to log in to the browser to view or download documents, or share them on the LAN through OS X Finder program management network server, which makes the work more efficient.

Qunhui QuickConnect Quick Connect+Browser = Cross-platform file sharing

With Mac’s own browser Safari, you can log in to Qunhui NAS by connecting through Qunhui QuickConnect, whether on the local area network or on the external network, even if there is no public IP, and you don’t need to toss about the routing settings. You just need to enter the link of Qunhui QuickConnect in the browser, such as http://QuickConnect.to/[ your QuickConnect account]. Cross-platform file sharing and exchange can be completed without third-party software and complicated settings.

Finder web server provides a more intimate experience

Not only can cross-platform file sharing and exchange of Mac be realized through the browser, but DSM supports AFP sharing protocol of Mac OS by default. In the local area network, you can find DS215j on the shared device as long as you open the Finder, and you can also share and manage files with Windows computers conveniently on the Mac after logging in to DSM.

A more economical backup method ——NAS turned into a space-time machine

Qunhui NAS can not only provide the above file sharing for Mac, but also support Time Machine backup, achieving the same system backup purpose as Time Capsule, without having to pay a high price to purchase it separately. The following describes how to back up your Mac to Qunhui NAS through Time Machine.

Step 1: Open the Qunhui NAS control panel-Shared Folder, create a new Time Machine folder, and set the permissions to read and write.

Step 3: In the Mac system, open the system preference setting-Time Machine, click "Select Disk", select the Time Machine server created in the previous step, and enter the NAS username and password to complete the setting.

After setting up, Qunhui NAS becomes the backup destination of Time Machine. DS215j provides a large storage space of up to 16TB, so Apple users don’t have to worry about insufficient backup storage space.

With years of efforts, Qunhui NAS has developed many tools to perfectly support Mac computers and iOS mobile devices, solve the problem of insufficient space for Apple users, and provide more possibilities for data sharing and storage.

A major breakthrough in non-invasive prenatal screening technology for fetal monogenic diseases

January 22, 2024, Academician Huang Hefeng, together with researchers from Zhejiang University and Fudan University, published the latest clinical research results in Nature Medicine, entitled Prospective Prenatal Cell-Free DNA Screening for Genetic Conditions of Heterogeneous Etiology. Using a new generation of non-invasive prenatal screening technology developed by our team, the clinical effectiveness of prenatal screening for fetal chromosomal diseases, microdeletion microreplication syndrome and monogenic diseases was verified in a prospective multicenter cohort study.

In this study, an innovative comprehensive non-invasive prenatal screening technology-synergistic allele-targeted enrichment sequencing was used to comprehensively screen different types of fetal genetic variation by detecting free DNA in maternal plasma. Studies have shown that this comprehensive non-invasive prenatal screening can accurately identify the fetal pathogenic variation at chromosome and monogenic level in high-risk pregnancy, which may improve the prenatal risk assessment of heterogeneous causes of genetic diseases, realize more accurate prenatal and perinatal medical management, and fill the gap in prenatal screening for new dominant monogenic diseases.

Research publication link:

https://www.nature.com/articles/s41591-023-02774-x#citeas

Academician Qiao Jie, Executive Vice President of Peking University/Director of Medical Department, Academician Yang Zhenglin, Dean of Sichuan Provincial People’s Hospital, Dean of Chongqing Women and Children Hospital (Chongqing Maternal and Child Health Hospital), and Qi Hongbo, Chairman-designate of Perinatal Branch of Chinese Medical Association, commented on this achievement.

Academician Qiao Jie pointed out in his comments, "The biggest innovation of this clinical study by Academician Huang Hefeng is to include monogenic diseases in the scope of non-invasive prenatal screening. This progress not only significantly improves the detection rate of fetal genetic diseases, but also provides safer, timely and accurate information for pregnant women and doctors in the decision-making and management of pregnancy, marking an important breakthrough in the field of genetic diseases and birth defects prevention and control."

Academician Yang Zhenglin pointed out in his comments that "the dominant monogenic disease caused by new mutation is the weak link in the current prenatal screening, and it is an inevitable trend for NIPT to include it in the comprehensive screening of fetal cfDNA. The research of Academician Huang Hefeng’s team not only proposed a novel and efficient technical path, but also demonstrated the clinical effectiveness of related technologies, providing important theoretical and practical basis for further improving prenatal diagnosis and prevention and treatment of hereditary birth defects. "

Dean Qi Hongbo pointed out in his comments, "This three-in-one comprehensive screening method has significantly improved the detection rate and demonstrated high accuracy, which proves its great potential in clinical application. If this method can be popularized in clinic, it will effectively fill the gap in prenatal screening for dominant monogenic diseases, which is of great practical significance for improving China’s prenatal screening system and prevention and control of birth defects. "

What is prenatal non-invasive screening?

Noninvasive prenatal screening (NIPS): It is a kind of prenatal screening technology. The screening targets are mainly trisomy 21, trisomy 18 and trisomy 13, which are common fetal chromosomal diseases. After 2013, it quickly integrated into the prenatal screening system and became the most effective and widely used prenatal screening method.

At present, non-invasive prenatal screening (NIPS) detects aneuploidy or microdeletion/microdeletion syndrome by analyzing fetal free DNA(cfDNA) in maternal peripheral blood. Because most of the maternal plasma cfDNA comes from the mother, it is difficult to detect fetal specific variation in high maternal background, and many hereditary diseases can not be detected at present.

What is comprehensive non-invasive prenatal screening technology?

Comprehensive non-invasive prenatal screening (cfDNA comprehensive screening) technology covers three main human genetic variations, namely chromosome aneuploidy, chromosome microdeletion and single gene variation, which expands the detection range of non-invasive prenatal screening and improves the detection accuracy, and is of great significance in the field of prenatal screening.

What did the study find?

The team established a new targeted enrichment method-COATE-SEQ (Figure 1), which realized multi-dimensional analysis of maternal and fetal free DNA, solved many technical defects of the first generation NIPT, and realized non-invasive prenatal detection of fetal chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic disease at the same time for the first time.

Figure 1 New generation NIPS technical process

This study evaluated the clinical effectiveness and increased detection efficiency of this new generation NIPS technology through a multicenter prospective clinical study lasting nearly 2 years.

During the period from April 24th, 2021 to September 10th, 2022, 1191 pregnant women (age ≥20 years, single pregnancy ≥12 weeks, abnormal fetal structure (including NT≥3mm), high risk of NIPT or maternal serological screening, or high risk of genetic diseases due to previous pregnancy history) from three maternity hospitals in different provinces of China were included in the study, and all the participants underwent a comprehensive prenatal cfDNA screening. Finally, the screening results of 1,090 pregnant women who met the criteria for ovulation were analyzed. Pathogenic genetic variation was detected in 135 cases (12.4%) of pregnancy through comprehensive cfDNA screening, which was confirmed by diagnostic tests, including 89 aneuploidies, 9 microdeletions and 37 single gene variations (Figure 2). Compared with the current standard screening for chromosomal abnormalities (NIPT), the detection rate of diagnostic genetic variation in comprehensive cfDNA screening increased by 60.7%, the sensitivity was 98.5% (95% CI, 94.3%-99.7%), and the specificity was 99.3% (95% CI, 98.4%-99.7%).

Figure 2 Detection rate of genetic variation in pregnancy with abnormal fetal structure

Among 876 cases of pregnancy with abnormal fetal structure, 98 cases (11.2%) detected diagnostic gene variation. Among them, 42 cases were autosomal aneuploidy (42.9%), 13 cases were sex aneuploidy (13.3%), 6 cases were microdeletion (6.1%) and 37 cases were single gene (37.8%). B in 876 cases of pregnancy with abnormal fetal structure, the detection rate of diagnostic genetic variation was the highest in lymphatic or hydrops abnormalities (36.9%), followed by skeletal abnormalities (24.7%) and multiple system abnormalities (23.3%). The highest detection rate of chromosomal abnormalities was lymphatic or hydrops abnormalities (32.6%), followed by multiple system abnormalities (19.2%), thickening of the transparent layer behind the neck (8.8%), heart defects (5.7%) and craniofacial abnormalities (5.7%). The highest detection rate of single gene abnormality is skeletal abnormality (23.5%), followed by lymphatic or hydrops abnormality (4.3%), multi-system abnormality (4.1%), FGR(2.9%) and brain developmental abnormality (2.2%).

What is the significance of this research?

Incorporating chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic diseases into fetal cfDNA screening is beneficial to prenatal diagnosis, can be used as an auxiliary tool for early identification in the first trimester of pregnancy, supplement the current imaging-based methods, and is also beneficial to prenatal screening and perinatal management. When pregnant women with abnormal fetus choose to continue pregnancy and refuse invasive surgery, this screening becomes particularly important. Comprehensive NIPS screening can provide more accurate prenatal screening for a wide range of hereditary diseases and provide valuable help for risk assessment and timely management of pregnancy.

Correspondents of this study are Zhejiang University/Director of Key Laboratory of Reproductive Genetics/Academician Huang Hefeng and Researcher Zhang Jinglan of Fudan University, Zhang Dan of Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Xu Chenming of Obstetrics and Gynecology Hospital affiliated to Fudan University and Wang Hua of Hunan Children’s Hospital. The co-first authors are Luo Qiong, the Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Wu Yiting and Chen Songchang, the Obstetrics and Gynecology Hospital affiliated to Fudan University, and Xi Hui, the Maternal and Child Health Hospital of Hunan Province. Chen Yuan, Jiang Ying, Chen Panpan, Liu Yifeng and Dong Min Yue also participated in the study.

It is the eternal pursuit of the development of non-invasive prenatal screening and the long-term research and development goal of the medical community to screen more kinds of important fetal genetic diseases simultaneously with a tube of maternal peripheral blood more accurately and efficiently.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is the leading unit of Zhejiang Prenatal Diagnosis Center, Zhejiang Fetal Medical Diagnosis and Treatment Center, Zhejiang Prenatal Diagnosis (Screening) Quality Control Center, Zhejiang Obstetric Medical Quality Control Center, Zhejiang Critical Pregnant Women Treatment Center, Zhejiang Remote Fetal Heart Monitoring and Interpretation Center, Zhejiang Labor Analgesia Technical Guidance Center, Zhejiang Maternal and Child Nursing Specialist Nurse Training Base and other institutions.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is a national key clinical specialty, a key (supporting) discipline in Zhejiang Province, and the leader unit of Zhejiang perinatal health care cooperation group. The annual delivery volume exceeds 20,000 person-times, among which the high-risk pregnancy exceeds 80%, the proportion of serious, difficult and critical cases exceeds 35%, and the success rate of maternal rescue basically reaches 100%. It has formed sub-specialties such as maternal medicine, fetal medicine and general obstetrics, and opened more than 20 specialty clinics such as fetal medicine clinic, prenatal diagnosis consultation clinic and gestational diabetes clinic. It has a very high rescue success rate for difficult and critical patients such as pregnancy complicated with refractory heart failure, pre-eclampsia critical state, acute fatty liver of pregnancy, amniotic fluid embolism, adult respiratory distress syndrome, severe prenatal hemorrhage and severe postpartum hemorrhage. In the basic and clinical research of pregnancy-induced hypertension, the diagnosis and treatment of intrahepatic cholestasis of pregnancy, the treatment of intrauterine growth retardation, the prognosis evaluation of intrauterine brain diseases and intrauterine kidney diseases, intrauterine fetal surgery such as fetal mirror, delivery room surgery, gestational diabetes mellitus, various fetal intrauterine monitoring, painless delivery and other fields, fruitful results have been achieved; He has accumulated rich clinical experience and management ability in premature delivery, premature rupture of membranes, twins, cervical incompetence, early-onset preeclampsia and early-onset intrahepatic cholestasis of pregnancy. It is an early large-scale unit in China to carry out prenatal diagnosis and fetal monitoring, and has established a prenatal screening system-prenatal diagnosis system-prenatal diagnosis management system.To make a multi-level cross-study on complicated and difficult fetal birth defects.

Source | Zhejiang University Women’s Hospital

Read the original text

作者归档 admin

Decision of the People’s Government of Inner Mongolia Autonomous Region on Abolishing Some Government Regulations

Country Garden is flat!

Chongqing Museum of Natural History will open the first treasure warehouse.

China Consumers Association named KFC： Using ＂blind boxes＂ to induce excessive food consumption, when boycotting.

Can you carry the banner to test SAIC Volkswagen Huiang 380TSI？

Besides Tom cruise, why is Mission Impossible 5 worth watching？

Attention! The latest release of Shaanxi CDC

Announcement of competitive consultation on digital scanning service of archives (secondary)

Project overview

I. Basic information of the project

Second, the applicant’s qualification requirements:

Third, the government procurement policies that need to be implemented in procurement projects

Fourth, obtain the procurement documents

V. Submission of response documents

Six, open

Seven, the announcement period

VIII. Other Supplementary Matters

9. Please contact us in the following ways for inquiries about this tender.

Advanced compulsory course of fruit powder

A major breakthrough in non-invasive prenatal screening technology for fetal monogenic diseases

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