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A major breakthrough in non-invasive prenatal screening technology for fetal monogenic diseases

January 22, 2024, Academician Huang Hefeng, together with researchers from Zhejiang University and Fudan University, published the latest clinical research results in Nature Medicine, entitled Prospective Prenatal Cell-Free DNA Screening for Genetic Conditions of Heterogeneous Etiology. Using a new generation of non-invasive prenatal screening technology developed by our team, the clinical effectiveness of prenatal screening for fetal chromosomal diseases, microdeletion microreplication syndrome and monogenic diseases was verified in a prospective multicenter cohort study.

In this study, an innovative comprehensive non-invasive prenatal screening technology-synergistic allele-targeted enrichment sequencing was used to comprehensively screen different types of fetal genetic variation by detecting free DNA in maternal plasma. Studies have shown that this comprehensive non-invasive prenatal screening can accurately identify the fetal pathogenic variation at chromosome and monogenic level in high-risk pregnancy, which may improve the prenatal risk assessment of heterogeneous causes of genetic diseases, realize more accurate prenatal and perinatal medical management, and fill the gap in prenatal screening for new dominant monogenic diseases.

Research publication link:

https://www.nature.com/articles/s41591-023-02774-x#citeas

Academician Qiao Jie, Executive Vice President of Peking University/Director of Medical Department, Academician Yang Zhenglin, Dean of Sichuan Provincial People’s Hospital, Dean of Chongqing Women and Children Hospital (Chongqing Maternal and Child Health Hospital), and Qi Hongbo, Chairman-designate of Perinatal Branch of Chinese Medical Association, commented on this achievement.

Academician Qiao Jie pointed out in his comments, "The biggest innovation of this clinical study by Academician Huang Hefeng is to include monogenic diseases in the scope of non-invasive prenatal screening. This progress not only significantly improves the detection rate of fetal genetic diseases, but also provides safer, timely and accurate information for pregnant women and doctors in the decision-making and management of pregnancy, marking an important breakthrough in the field of genetic diseases and birth defects prevention and control."

Academician Yang Zhenglin pointed out in his comments that "the dominant monogenic disease caused by new mutation is the weak link in the current prenatal screening, and it is an inevitable trend for NIPT to include it in the comprehensive screening of fetal cfDNA. The research of Academician Huang Hefeng’s team not only proposed a novel and efficient technical path, but also demonstrated the clinical effectiveness of related technologies, providing important theoretical and practical basis for further improving prenatal diagnosis and prevention and treatment of hereditary birth defects. "

Dean Qi Hongbo pointed out in his comments, "This three-in-one comprehensive screening method has significantly improved the detection rate and demonstrated high accuracy, which proves its great potential in clinical application. If this method can be popularized in clinic, it will effectively fill the gap in prenatal screening for dominant monogenic diseases, which is of great practical significance for improving China’s prenatal screening system and prevention and control of birth defects. "

What is prenatal non-invasive screening?

Noninvasive prenatal screening (NIPS): It is a kind of prenatal screening technology. The screening targets are mainly trisomy 21, trisomy 18 and trisomy 13, which are common fetal chromosomal diseases. After 2013, it quickly integrated into the prenatal screening system and became the most effective and widely used prenatal screening method.

At present, non-invasive prenatal screening (NIPS) detects aneuploidy or microdeletion/microdeletion syndrome by analyzing fetal free DNA(cfDNA) in maternal peripheral blood. Because most of the maternal plasma cfDNA comes from the mother, it is difficult to detect fetal specific variation in high maternal background, and many hereditary diseases can not be detected at present.

What is comprehensive non-invasive prenatal screening technology?

Comprehensive non-invasive prenatal screening (cfDNA comprehensive screening) technology covers three main human genetic variations, namely chromosome aneuploidy, chromosome microdeletion and single gene variation, which expands the detection range of non-invasive prenatal screening and improves the detection accuracy, and is of great significance in the field of prenatal screening.

What did the study find?

The team established a new targeted enrichment method-COATE-SEQ (Figure 1), which realized multi-dimensional analysis of maternal and fetal free DNA, solved many technical defects of the first generation NIPT, and realized non-invasive prenatal detection of fetal chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic disease at the same time for the first time.

Figure 1 New generation NIPS technical process

This study evaluated the clinical effectiveness and increased detection efficiency of this new generation NIPS technology through a multicenter prospective clinical study lasting nearly 2 years.

During the period from April 24th, 2021 to September 10th, 2022, 1191 pregnant women (age ≥20 years, single pregnancy ≥12 weeks, abnormal fetal structure (including NT≥3mm), high risk of NIPT or maternal serological screening, or high risk of genetic diseases due to previous pregnancy history) from three maternity hospitals in different provinces of China were included in the study, and all the participants underwent a comprehensive prenatal cfDNA screening. Finally, the screening results of 1,090 pregnant women who met the criteria for ovulation were analyzed. Pathogenic genetic variation was detected in 135 cases (12.4%) of pregnancy through comprehensive cfDNA screening, which was confirmed by diagnostic tests, including 89 aneuploidies, 9 microdeletions and 37 single gene variations (Figure 2). Compared with the current standard screening for chromosomal abnormalities (NIPT), the detection rate of diagnostic genetic variation in comprehensive cfDNA screening increased by 60.7%, the sensitivity was 98.5% (95% CI, 94.3%-99.7%), and the specificity was 99.3% (95% CI, 98.4%-99.7%).

Figure 2 Detection rate of genetic variation in pregnancy with abnormal fetal structure

Among 876 cases of pregnancy with abnormal fetal structure, 98 cases (11.2%) detected diagnostic gene variation. Among them, 42 cases were autosomal aneuploidy (42.9%), 13 cases were sex aneuploidy (13.3%), 6 cases were microdeletion (6.1%) and 37 cases were single gene (37.8%). B in 876 cases of pregnancy with abnormal fetal structure, the detection rate of diagnostic genetic variation was the highest in lymphatic or hydrops abnormalities (36.9%), followed by skeletal abnormalities (24.7%) and multiple system abnormalities (23.3%). The highest detection rate of chromosomal abnormalities was lymphatic or hydrops abnormalities (32.6%), followed by multiple system abnormalities (19.2%), thickening of the transparent layer behind the neck (8.8%), heart defects (5.7%) and craniofacial abnormalities (5.7%). The highest detection rate of single gene abnormality is skeletal abnormality (23.5%), followed by lymphatic or hydrops abnormality (4.3%), multi-system abnormality (4.1%), FGR(2.9%) and brain developmental abnormality (2.2%).

What is the significance of this research?

Incorporating chromosome aneuploidy, chromosome microdeletion syndrome and monogenic genetic diseases into fetal cfDNA screening is beneficial to prenatal diagnosis, can be used as an auxiliary tool for early identification in the first trimester of pregnancy, supplement the current imaging-based methods, and is also beneficial to prenatal screening and perinatal management. When pregnant women with abnormal fetus choose to continue pregnancy and refuse invasive surgery, this screening becomes particularly important. Comprehensive NIPS screening can provide more accurate prenatal screening for a wide range of hereditary diseases and provide valuable help for risk assessment and timely management of pregnancy.

Correspondents of this study are Zhejiang University/Director of Key Laboratory of Reproductive Genetics/Academician Huang Hefeng and Researcher Zhang Jinglan of Fudan University, Zhang Dan of Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Xu Chenming of Obstetrics and Gynecology Hospital affiliated to Fudan University and Wang Hua of Hunan Children’s Hospital. The co-first authors are Luo Qiong, the Obstetrics and Gynecology Hospital affiliated to Zhejiang University Medical College, Wu Yiting and Chen Songchang, the Obstetrics and Gynecology Hospital affiliated to Fudan University, and Xi Hui, the Maternal and Child Health Hospital of Hunan Province. Chen Yuan, Jiang Ying, Chen Panpan, Liu Yifeng and Dong Min Yue also participated in the study.

It is the eternal pursuit of the development of non-invasive prenatal screening and the long-term research and development goal of the medical community to screen more kinds of important fetal genetic diseases simultaneously with a tube of maternal peripheral blood more accurately and efficiently.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is the leading unit of Zhejiang Prenatal Diagnosis Center, Zhejiang Fetal Medical Diagnosis and Treatment Center, Zhejiang Prenatal Diagnosis (Screening) Quality Control Center, Zhejiang Obstetric Medical Quality Control Center, Zhejiang Critical Pregnant Women Treatment Center, Zhejiang Remote Fetal Heart Monitoring and Interpretation Center, Zhejiang Labor Analgesia Technical Guidance Center, Zhejiang Maternal and Child Nursing Specialist Nurse Training Base and other institutions.

Obstetrics and Gynecology Hospital affiliated to Zhejiang University School of Medicine is a national key clinical specialty, a key (supporting) discipline in Zhejiang Province, and the leader unit of Zhejiang perinatal health care cooperation group. The annual delivery volume exceeds 20,000 person-times, among which the high-risk pregnancy exceeds 80%, the proportion of serious, difficult and critical cases exceeds 35%, and the success rate of maternal rescue basically reaches 100%. It has formed sub-specialties such as maternal medicine, fetal medicine and general obstetrics, and opened more than 20 specialty clinics such as fetal medicine clinic, prenatal diagnosis consultation clinic and gestational diabetes clinic. It has a very high rescue success rate for difficult and critical patients such as pregnancy complicated with refractory heart failure, pre-eclampsia critical state, acute fatty liver of pregnancy, amniotic fluid embolism, adult respiratory distress syndrome, severe prenatal hemorrhage and severe postpartum hemorrhage. In the basic and clinical research of pregnancy-induced hypertension, the diagnosis and treatment of intrahepatic cholestasis of pregnancy, the treatment of intrauterine growth retardation, the prognosis evaluation of intrauterine brain diseases and intrauterine kidney diseases, intrauterine fetal surgery such as fetal mirror, delivery room surgery, gestational diabetes mellitus, various fetal intrauterine monitoring, painless delivery and other fields, fruitful results have been achieved; He has accumulated rich clinical experience and management ability in premature delivery, premature rupture of membranes, twins, cervical incompetence, early-onset preeclampsia and early-onset intrahepatic cholestasis of pregnancy. It is an early large-scale unit in China to carry out prenatal diagnosis and fetal monitoring, and has established a prenatal screening system-prenatal diagnosis system-prenatal diagnosis management system.To make a multi-level cross-study on complicated and difficult fetal birth defects.

Source | Zhejiang University Women’s Hospital

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2023 People’s Livelihood Answers Thick Planting High Value Ecological ＂Green＂ Background Beautiful China Re-score a new chapter.

　　CCTV News:A good ecological environment is the most inclusive welfare of people’s livelihood. In order to meet the people’s pursuit of a beautiful ecological environment, all relevant state departments and governments at all levels are making unremitting efforts.

　　According to the latest monitoring by the Ministry of Ecology and Environment, from January to 1&mdash in 2023; In November, the national water ecological environment quality was stable and good, and the excellent proportion of surface water was 88.7%, up 1.1 percentage points year-on-year; The proportion of water quality inferior to Grade V was 0.7%, which was flat year-on-year.

　　In terms of air quality, the average concentration of PM2.5 in 339 cities at prefecture level and above was 29 μ g/m3, up by 3.6% over the same period in 2022. This means that the national average concentration of PM2.5 has increased by 1 μ g/m3 compared with the same period in 2022.

　　Liu Bingjiang, chief engineer of the Ministry of Ecology and Environment, said that this achievement was hard-won. Because according to the forecast at the beginning of the year, the national PM2.5 concentration will increase by at least 7 μ g/m3 in 2023. Two major factors lead to severe challenges in the battle against pollution in 2023. After the transition of epidemic prevention and control in 2023, the economy resumed development, which correspondingly brought about an increase in pollutant emissions. In addition, in 2023, China suffered 17 sandstorms, the most in the past 10 years, 50% higher than the average.

　　The achievement of steady progress is that all localities and departments face difficulties, make overall plans, make precise efforts, increase pollution reduction efforts, and effectively slow down the momentum of pollution rebound.

　　In 2023, the ultra-low emission transformation of the national steel industry will add more than 200 million tons, more than the sum of the previous four years. As the "main battlefield" of air pollution control, the green transformation of the steel industry has greatly reduced the annual air pollutant emissions.

　　In 2023, the treatment of volatile organic pollutants involving tens of thousands of enterprises has been completed. This means that the weak links in the field of air pollution control in China are gradually being broken.

　　In 2023, the number of clean heating renovation in the northern region will increase by another 2 million, achieving warmth inside the house and blue sky outside.

　　In 2023, if the blue sky defense battle is a microgram-by-microgram battle, the clear water defense battle is the guardian of fish and grass in the river. Since 2023, many heavy documents such as "Water Ecological Environment Protection Plan for Key Watershed" have been issued one after another. A series of special actions such as the investigation of sewage outlets entering the river into the sea, the remediation of black and odorous water bodies in rural areas, and the environmental protection of drinking water sources continued to be launched.

　　In 2023, both the Yangtze River and the Yellow River will maintain Grade II water quality. The Yangtze River is expected to reach Grade II water quality for four consecutive years, and the Yellow River is expected to reach Grade II water quality for two consecutive years.

　　Pingxiang, Jiangxi: The grapefruit in my hometown is ripe.

　　There is a river at the junction of Jiangxi and Hunan provinces, which is a secondary tributary of the Yangtze River. It is called Pingshui River in Jiangxi and Laishui in Hunan. River basin management needs the joint management of upstream and downstream. In a short period of four years, Pingshui River has entered the top 30 list of water environmental quality changes announced by the Ministry of Ecology and Environment from Grade IV or even worse than Grade V in the national examination section. In this process, the villager Lao He, who lives by the river, is not only the witness and witness of this kind of environmental governance, but also the defender and beneficiary of the ecological environment.

　　In Dayi Village, Pingxiang City, Jiangxi Province, standing on a small bridge on the Pingshui River, there are two small houses in the upper and lower reaches. This is an automatic water quality monitoring station set up by Pingxiang City, Jiangxi Province and Zhuzhou City, Hunan Province near the Jinyushi section of the Pingshui River. At one time, a group of data from here touched many people’s hearts. Before 2018, many water quality indicators of Jinyushi section exceeded Class III water quality standards for a long time, and some months were Class IV or even worse than Class V..

　　After investigation, the relevant departments found that a large number of steel and chemical enterprises gathered in Pingxiang, Jiangxi, upstream of Lishui, while industries such as ceramics and building materials were laid out along the river in Zhuzhou, Hunan, downstream. The worrying monitoring data forced the two sides to break the industrial structure. It is precisely for this reason that He Haiping’s furniture processing factory, which has been in operation for 10 years, is facing a difficult choice.

　　The processing factory opened by Lao He mainly paints furniture. Although this small factory can make a gross profit of 100,000 yuan per year, it pollutes the surrounding air and water sources. In 2019, Pingxiang invested in the construction of sewage treatment facilities, shutting down and banning 107 scattered, chaotic and polluting enterprises, and Lao He’s small processing plant was also shut down after repeated persuasion in the village. Do something more? At the suggestion of the village, Lao Hao tried to plant excellent varieties of rock sugar pomelo on the barren hills.

　　Just when the first grapefruit seedling was planted in CSI, the highlight of the joint governance of the basins in Jiangxi and Hunan provinces also kicked off. In 2019, the two provinces signed a series of horizontal ecological protection agreements. Pingxiang in the upper reaches and Zhuzhou in the lower reaches jointly promoted the protection and governance of backwater in terms of information sharing and joint law enforcement. The two sides agreed that in three years, if the water quality of Jiangxi flowing into Hunan reaches or exceeds the national assessment target Class III, Hunan will compensate Jiangxi ecologically. On the contrary, Jiangxi compensates Hunan.

　　With the implementation of a series of measures, the ecology of Laishui has continued to improve, and the water quality has completely reached the standard. Pingxiang has also received 140 million yuan of river basin compensation from the central and provincial governments and 30 million yuan of ecological gambling compensation from Hunan. In November 2023, the two provinces also reviewed and approved the Pingshui River — The Regulation on Collaborative Protection of the Lishui River Basin has further promoted the co-management and co-governance of the upper and lower reaches through legislation.

　　At the end of the year and the beginning of the year, Lao He had a happy event in his family, watering the sweet river. The rock sugar pomelo he had planted hard for three years successfully bore fruit for the first time, and the quality of the fruit was beyond his expectation.

　　Qitaihe River in Heilongjiang Province: Coal City Becomes Beautiful City

　　There is a small border town called Qitaihe in Heilongjiang Province, which is an industrial city born of coal and prospered by coal. In the process of the city’s high-quality transformation, the "heat" of Qitaihe River in 2023 was a bit high.

　　In winter, the Qitaihe River is colder than 20 degrees below zero. Every day, hundreds of residents and tourists come to the Wanbao Lotus Pond Ice rink to skate, attracting them not only the free ice rink, but also the blue sky and white clouds that can be called the "best background board".

　　The "heat" of Qitaihe in 2023 extends from outdoor to indoor. After the renovation of old pipes in summer, the residents’ homes are as warm as spring, and the temperature remains above 20℃. Different from the past, the heating season in 2023 can no longer smell coal smoke.

　　Xu Quan, stationmaster of Lantian Gas Power Station in qitaihe city, Heilongjiang:In the past, when Qitaihe reached the heating season, the sky was gray and the air was choking. In the words of the people, all the domestic birds flying in the sky are black.

　　Xu Quan’s experience is the epitome of the transformation of Qitaihe River. Having dealt with coal for more than 20 years, what Lao Xu didn’t expect was that gas, the number one "natural enemy" endangering coal mining, has now turned into a "treasure" for power generation and heating. In the past two years, after becoming the stationmaster of the gas power station, Xu Quan, a coal miner, personally devoted himself to the front line of guarding the blue sky.

　　Let the life of ordinary people have temperature and brightness. Qitaihe will fully promote clean energy heating in 2023 and promote the use of biomass stoves for heating in rural areas. Qitaihe closely combined environmental governance with improving people’s livelihood, cured chronic diseases, inserted green at the seams, and the "happiness list" that the masses cared about became a beautiful life within reach today.

　　The beauty of Qitaihe River in winter adds a heroic temperament. There have been 12 world champions of ice and snow sports here, and the reputation of "champion city" has promoted the rapid development of ice and snow economy. In 2023, Qitaihe launched 21 tourist routes and held events such as the legendary ice and snow carnival. The number of tourist receptions reached 670,000, and the tourism income reached 164 million yuan, a year-on-year increase of 50%.

　　Fight the battle of pollution prevention and control, and re-compose a new chapter of beautiful China

　　It is the unshirkable responsibility of government departments to let people breathe fresh air, drink clean water and live in a beautiful environment, and it is also the direction of unremitting efforts. The year 2024 is a crucial year to realize the objectives and tasks of the 14th Five-Year Plan, and it is also an important period for the construction of beautiful China. In 2024, what aspects will the construction of beautiful China continue to exert?

　　According to the relevant person in charge of the Ministry of Ecology and Environment, at present, the structural, root and trend pressures of China’s ecological environment protection have not been fundamentally alleviated, so it is one of the important tasks for the construction of beautiful China in 2024 to fight the tough battle of pollution prevention. In terms of defending the blue sky, China will promote strict control of increments, reduce emissions, accelerate the development of green and low-carbon industries, and strengthen financial, taxation, price and other policy support.

　　In the battle for clear water, in 2024, China will consolidate and improve the quality of water environment, highlighting the protection and restoration of water ecology. Do a good job in the renovation of sewage outlets into the river, and strive to complete the renovation of the whole Yangtze River basin by the end of 2025, and complete the renovation of sewage outlets in the main stream and important tributaries of the Yellow River and other basins. Pilot water ecological assessment will be carried out in 17 provinces in the Yangtze River basin, and more than 2,700 water bodies will be basically built into beautiful rivers and lakes with "clear water and green banks and shallow fish" by 2035. Consolidate and improve the effectiveness of black and odorous water treatment in prefecture-level and above cities, and increase the intensity of black and odorous water treatment in county-level cities.

　　In 2024, China’s ecological environment will be bluer, greener and clearer, and Wan Li’s rivers and mountains will be more colorful!

The 2024 League of Legends Global Finals knockout is about to start, and all LPL members will meet in Paris.

The 2024 League of Legends Global Finals knockout is about to start, and all LPL members will meet in Paris.: 2024-10-17 17:51:21.0 Source: Northland. com

With the end of the Swiss round of the League of Legends Global Finals in 2024, the No.1 seed BLG Xingji Meizu, No.2 seed TES Team, No.3 seed Suzhou LNG No.9 Electric and No.4 seed WBG TapTap in LPL Division have all advanced to the knockout stage and successfully joined Paris. The knockout round will officially start at the Adidas Stadium in Paris, France at 20:00 on October 17th, Beijing time, and the eight teams from Switzerland will face greater challenges!

【man of valorfear nothing,LPL gathers in Paris】

In the previous Swiss Round, 16 teams from different divisions competed fiercely, and finally eight teams broke through. They are four teams in ——LPL, BLG, TES, LNG and WBG, HLE, GEN and T1 in LCK, and FLY in LCS, and they will jointly compete for the semi-finals in 2024! It is worth mentioning that the LPL division once again achieved full promotion and jointly fought in the knockout stage!

According to the lottery results of the knockout stage, HLE, the first seed of LNG, WBG, BLG and LCK, gathered in the upper half, while the lower half was composed of TES, T1, GEN and FLY. Eight teams will launch a new round of fighting in their respective halves, and the final winners in the upper and lower halves will travel from Paris to London to compete for the final championship trophy!

【Strong man versus strong man,onestrugglesuperiority or inferiority】

On October 17, the first battle of the knockout will usher in a "LPL civil war", LNG against WBG. The two teams have played several times in the league this year, and they have won and lost each other. This time, the battle will be more intense. In addition to the stable performance of Scout and GALA, LNG’s excellent tactics, strategies and operations also demonstrated the team’s extraordinary strength, which also made them the first team in the Swiss round to advance 3-0. In contrast, WBG’s road to promotion is bumpy, but many experienced players in the team can always bring surprises at critical moments, especially Breathe, who brought five MVP performances, and Tarzan, a wild player from Morgana, who made his debut in this competition under the lock of "life and death". It is expected who will win the first round of the quarter-finals.

On the second day, it was a strong confrontation between the top seeds in the two major divisions, BLG against HLE team. As the last team in LPL Division to advance to the quarter-finals, BLG’s Swiss round competition was not smooth sailing, but in the final match against the No.1 seed G2 team in LEC Division, the summoners also saw the competitive strength of BLG after the state callback. In this match between BLG and HLE, the summoners are most looking forward to the duel between Elk and Viper, both of whom are very comprehensive players, and both of them have played the role of winning the game in previous competitions. At the same time, it will be the first time that HLE has faced the LPL team in this global finals. What is the result, and whether BLG can win the key game, let us wait and see!

The competition on October 19th is also a duel between LPL and LCK. TES will face the T1 team, the champion of last year’s global finals. The two sides met in the previous Swiss round Bo1, when TES won with better team fighting strength. TES performed well in the Swiss round, and Creme, a middle-road player who entered the stage of the global finals for the first time, dared to fight and became the player who scored the highest average injury in the Swiss round. But on the other side, it is the legendary player Faker who holds the "four crowns" in the global finals. His clear game ideas and team battle handling will bring great challenges to TES. The two teams, who are more and more brave, meet again. I believe they will bring a wonderful confrontation to the summoners, and I also look forward to TES’ hard work and further success!

On the fourth day, FLY, the only fire in LCS Division, will face GEN, a strong team in LCK Division. FLY finally defeated the TL team in the same division in the Swiss Round and successfully got the last quarter-finals ticket. They left a deep impression on the summoners with their unique heroic choices in the Swiss Round, and the play of veteran Bwipo may be the key to FLY’s victory. GEN continued their consistent and stable performance in the Swiss round, and the "middle field combination" of Chovy and Canyon always led the team to control the rhythm of the game and break the opponent’s defense line one by one. What kind of confrontation will the two teams bring? Don’t miss it.

Watch the 2024 League of Legends Global Finals. You can watch the whole event through League of Legends client, Pocket League of Legends and League of Legends events, LPL.QQ.COM in official website, Huya Live, DouYu, BILIBILI Live, Migu Video, Tencent Video, Tencent Sports, Sina Weibo, WeChat Video and bestv.

In addition, the 2024 League of Legends Global Finals cinema viewing has also been officially opened. Now, search the movie competition alliance applet to get the billing information of your nearby viewing point, and cheer loudly offline together!

Fight without regret and move forward side by side. I believe that all four LPL teams will meet the upcoming challenges in the best condition. At 20 o’clock on October 17 th, Beijing time, the elimination of the 2024 League of Legends Global Finals officially started! The world focuses, seeing is believing, and we witness it together!

86 yuan, where the roadside stalls buy mala Tang？ Official of Tianxin District, Changsha： Ordering vendors to correct and punish.

　　Cctv newsAccording to the Office of Network Security and Informatization Committee of Tianxin District Committee of Changsha City, on April 22, netizens reported that a customer had a dispute with a mobile vendor selling mala Tang at the downstairs of Yunxi Chaohui in Tianxin District due to price issues. Tianxin District Market Supervision Administration and Tianxin District Urban Management Comprehensive Law Enforcement Brigade conducted investigation and disposal according to law after learning the situation.

　　Tianxin District Urban Management Comprehensive Law Enforcement Brigade has ordered the mobile vendor to correct and punish the illegal stall operation according to the relevant provisions of Changsha City Appearance and Environmental Sanitation Management Measures; Tianxin District Market Supervision and Administration Bureau has dealt with the behavior of the mobile vendor in its business activities without clearly marking the price, which has been handled according to the Price Law of People’s Republic of China (PRC).

　　In the next step, Tianxin District Urban Management Comprehensive Law Enforcement Brigade and Tianxin District Market Supervision and Administration Bureau will jointly carry out centralized rectification of illegal stalls and unmarked business practices to maintain a good market operation order.

Notice of Beijing Municipal Market Supervision Administration and other 10 departments on printing and distributing some measures to further promote the development of advertising industry

Jing Shi Jian Fa [2023] No.81

All relevant units:

　　In order to implement the requirements of the Municipal Party Committee and the Municipal Government on promoting the high-quality development of the capital, develop and expand the advertising market scale, effectively reduce the burden on enterprises, continuously stimulate the vitality of the advertising market, and promote the steady recovery and development of the advertising industry in our city, the Municipal Market Supervision Bureau and other ten departments jointly formulated the "Several Measures on Further Promoting the Development of the Advertising Industry", which was approved by the municipal government and is hereby issued. Please conscientiously implement it in light of the actual work.

Beijing Municipal Market Supervision Administration　　　　

beijing municipal commission of development and reform　　　　

beijing finance bureau　　　　

Beijing Municipal Science and Technology Commission, Zhongguancun Science Park Management Committee　　　　

Beijing Bureau of Economy and Information Technology　　　　

Beijing Municipal Government Affairs Service Management Bureau　　　　

Beijing Intellectual Property Office　　　　

Beijing Supervision Bureau of the State Financial Supervision and Administration Bureau　　　　

Beijing local financial supervision and management bureau　　　　

China People’s Bank Beijing Branch　　　　

October 24, 2023　　

Some measures to further promote the development of advertising industry

　　Advertising plays an important role in promoting consumption, spreading social civilization and absorbing employment, and is an important force to promote the construction of Beijing as a national cultural center and an international consumption center city. In order to further serve and integrate into the new development pattern of the capital, promote the sustained, stable and healthy development of the advertising industry, and fully stimulate the endogenous power and development vitality of the industry, the following measures are formulated according to the work deployment of the municipal government.

　　First, adhere to overall development and safety, revise and improve the guidelines, enhance risk management and control capabilities, and encourage and support advertising in various fields that promote high-quality economic and social development. (Responsible departments: Municipal Market Supervision Bureau and Municipal Financial Supervision Bureau)

　　Two, support advertising enterprises to use the guarantee to increase credit financing. Eligible advertising enterprise loans can obtain government financing guarantee services. (Responsible departments: Municipal Finance Bureau, Municipal Financial Supervision Bureau, Beijing Supervision Bureau of the State Financial Supervision Administration)

　　Third, support small and medium-sized enterprises in the advertising industry to handle the first loan business through the Beijing Loan Service Center and enjoy discount or guarantee fee subsidies. (Responsible departments: Municipal Economic and Information Technology Bureau, Municipal Government Affairs Service Bureau, Municipal Finance Bureau, Municipal Financial Supervision Bureau, Beijing Supervision Bureau of State Financial Supervision and Administration Bureau, Beijing Branch of China People’s Bank)

　　Four, support advertising enterprises to handle intellectual property pledge guarantee business. Discount subsidies will be given to enterprises that have obtained bank intellectual property pledge loans and meet the requirements. (Responsible departments: Municipal Intellectual Property Office, Municipal Finance Bureau, Municipal Financial Supervision Bureau, Beijing Branch of China People’s Bank, Beijing Supervision Bureau of State Financial Supervision and Administration)

　　Five, support advertising enterprises to use accounts receivable, cash flow, equipment, etc. as collateral to apply for mortgage loans from banks to solve short-term financing needs. (Responsible departments: Municipal Financial Supervision Bureau, Beijing Branch of People’s Bank of China, Beijing Supervision Bureau of State Financial Supervision and Administration)

　　Six, support advertising enterprises to apply for the city’s cultural and financial integration development funds, to meet the conditions of advertising enterprises to enjoy investment and loan awards, rent, cultural industry risk compensation policy support. (Responsible department: Municipal Finance Bureau)

　　Seven, formulate a "white list" of advertising enterprises, relying on the Beijing bank-enterprise docking system to achieve accurate and effective docking of bank-enterprise financing in the advertising industry. Create innovative loan support tools for small and micro enterprises in Beijing, and explore the establishment of loan risk compensation and risk sharing mechanism for advertising enterprises. (Responsible departments: Municipal Market Supervision Bureau, Municipal Financial Supervision Bureau, Beijing Branch of China People’s Bank)

　　Eight, encourage qualified advertising enterprises to declare the identification of high-tech enterprises from the perspectives of radio, film and television technology, cultural and creative industry support technology, software, research and development and design services; Support advertising enterprises to unite with related manufacturing enterprises and actively explore the development model of integration of the two industries. (Responsible department: Municipal Science and Technology Commission, Zhongguancun Management Committee, Municipal Development and Reform Commission)

　　Nine, orderly revitalize idle land and space resources to develop the advertising industry, and give the municipal government fixed assets investment subsidy funds to meet the requirements of the transformation and utilization of old factories, inefficient buildings and other stock space to build advertising industrial parks. (Responsible department: Municipal Development and Reform Commission, Municipal Market Supervision Bureau)

　　Ten, encourage all districts to make full use of the relevant funds at the urban level to formulate policies to support the development of the advertising industry, and promote the stable and healthy development of the industry. (Responsible department: Municipal Finance Bureau, district governments)

23 Nissan Tule 4.0 Middle East Edition with a lock from more than 500,000

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　　23 models (configuration | inquiry) XE country VI B

　　White/meter. Black/meter, large screen reflection?

　　White/black. Black/black, no reflection on the small screen, car purchase hotline: Manager Peng: 17720015375 "WeChat"

　　Configuration: 4.0L V6 7-speed automatic, limited slip lock, rear differential lock, front and rear parking radar, front 4 rear 4 electric eyes 8 airbags 18 wheels LED headlights and daytime running lights, electric rearview mirror, cruise fixed speed 7 Yang, dual zone automatic air conditioning, cloth seat

　　Company Name: Tianjin Bangyu International Trade Co., Ltd.

　　Buying Hotline: Manager Peng: 17720015375 WeChat

　　Address: No. 288, Jingmen Avenue, Binhai New Area Free Trade Zone, Tianjin

　　Disclaimer: The above car purchase discount information is provided by the comprehensive dealer on this website. Due to market factors, the price fluctuates greatly, and it is only for car purchase reference. Its authenticity, accuracy and legality are the responsibility of the dealer. This website does not provide any guarantee and does not assume any legal responsibility.

Original Geely Boyue L interior design new highlights interpretation, emotional interaction or the direction of future model development

Geely BoyueLRecently, the interior design of the car was exposed, and the concept car was adopted. "VIsion SThe interior design idea of "tarburst" has added many new design features to the interior, BoyueLThe interior design of Geely Automobile can be said to be the latest design idea of Geely Automobile, from which we can also see the interior design features of Geely Automobile’s next models. There are also some new details in the details, which are very interesting. Let’s take a look today.

Geely officials say BoyueLThe interior design is "Digital Symphony Technology Aesthetics" design concept, which can also be seen from the name, BoyueLThe interior design takes digitalization, intelligence and technology as the main theme of interior design. Among them, Geely launched the first in the brand13.2Inch straight waterfall large screen, surround emotional light curtain, crystal diamond stopper, headrest sound and other details further highlight BoyueLThe sense of interior technology. Interior color scheme BoyueLYes.2A different scheme, one is brown+Blue "Autumn Field Brown", the other is white+Blue "Winter Snow Mountain White".

In terms of interior materials, a large number of suede materials are used in the car, and the use of a large number of soft materials also enhances the luxury experience of users’ daily cars. With the first-ever wraparound emotional light curtain, it is even more interesting. The wraparound emotional light curtain is these vertical strips of different lengths in the interior, and there are a total of light strips27Group, surround the entire center console and the door panel of the front door. The light strip can present lighting effects such as voiceprint, breathing, and water flow changes. When the vehicle is in different states such as music rhythm, nap mode, voice interaction, and air conditioner linkage, it can present different light effects to realize the user’s "emotional" linkage, so that the machine also presents a certain sense of "emotion". This function is personally preferred. Now many young users have similar lighting designs when building their own study or e-sports room. Adding such a design in the car makes the car have "temperature".

BoyueLcarried on13.2Inch touch multimedia screen with a resolution of1440x1920,It is close to the vertical screen in size.4What is it?3Screen, in terms of pixel density, the clarity should be better, and you need to wait for the real car experience. This is also the first time Geely has used it.13.2Inch size screen, the surface of the screen has been treated with anti-fingerprint (oleophobic coating), anti-reflection coating, and anti-glare film, and the effect under strong light is worth looking forward to. The large screen is pre-installed with Geely’s Galaxy.OSIntelligence systemAIR version (specially adapted)13.2Inch brand new version). The screen can also be followed by10.25Inch full LCD meter and25.6inchAR-HUDHead up display linkage, to achieve three-screen linkage function.

Milky WayOSIt is the mainstream on-board intelligent car system on Geely Automobile. The current mainstream configuration is YikatongE02Chip, match12.3Inch multimedia screen. But BoyueLUsed on13.2Inch multimedia screen, and not surprisingly, it will be powered by Qualcomm Snapdragon.8155The car-grade chip acts as the brain of the car-machine system (Xingyue)LAlso carry8155)So in order to adapt to the new hardware, Geely Automobile developed the GalaxyOS AIR version, compared to the mainstream galaxyOSVersion,AIR version adoptsFReed TOuch lightnessUIDesign (that is, the new system interface design), the use of short URL design in the operation interaction, the user’s commonly used functions are just a click away, improve the user’s efficiency.

BoyueLEquipped with a sound system from HARMAN Infinity. Of course, if there is no accident, this is the top configuration, and it may also be presented in the form of an optional package. There are total sound systems11A speaker, among which the more special is the headrest sound arranged at the driver’s headrest, which can separate the driving signal from the entertainment signal, that is, the music and navigation signals are played separately, so that the music navigation does not interfere with each other. The sound system has three music modes: private, driving and sharing. In recent years, Geely cars have often carriedBOSESound system, HARMAN Infinity audio is generally used by Lynk & Co, so BoyueLThe music experience is still worth looking forward to.

BoyueLIt is not a model with an antibacterial steering wheel. Among other Geely models, the antibacterial steering wheel is already one of the more mature configurations. For example, ColorfulCOOL,JiajiLAnd other models are equipped with antibacterial steering wheels or antibacterial interiors. The antibacterial steering wheel will add nano-silver ions to the material during production. Through the sterilization effect of nano-silver ions, common pathogenic bacteria such as Staphylococcus aureus and Escherichia coli can be killed to protect the health of the occupants. BoyueLThe antibacterial steering wheel is designed with an e-sports handle, which is functional in terms of suppression, sterilization, disinfection, and deodorization. Perhaps its process is different from that of other models.

BoyueLThis time, a newly designed electronic stopper is adopted, which is different from other Geely models. Geely’s current electronic stopper handles still have many shapes, XingyueL,EmgrandSThe aircraft-style stopper on the aircraft, the Jiaji Platinum Edition, the diamond-shaped stopper on the Boyue Asian Games Edition, the ColorfulCOOL,BinruiCOOLUse the Thor Black Block handle etc. onLThe crystal diamond stopper used on the phone is more eye-catching than other stoppers, and the shape is thicker. The inner laser of the stopper is engraved with "Thor Power".logo,It’s still nice.

BoyueLThe seat design on the car adopts a new shape, compared to other Geely models, the BoyueLThe seat design strengthens the waist support and shoulder support, and the sitting feeling is worth looking forward to. The waist support position is made of suede, and the use of fur material can also strengthen the friction at the waist to ensure the driver’s intense driving feeling. Compared with other Geely models, BoyueLAdjustable leg rests are added to the seat, making it easier for users of different heights to find a more suitable posture for them. The seat is equipped with seat suction, heating, memory and other functions in the details, and the functionality is in the past.

BoyueLThe sun visor on has made a unique design, and the sun visor adoptsPCOptical materials can block ultraviolet rays during the day and prevent high beams from facing the car at night. Functionally, it is similar to the design of sunglasses. At present, there are no other models on the market with similar designs, but there are similar sunshade accessories sold in some online stores. But from personal experience, it remains to be seen whether sunglasses visors have any value before drawing conclusions. After all, most users will place special sunglasses in the car, and the effect of some advanced polarized sunglasses will definitely be better than that of sunglasses visors. But taking a step back, the industry must have some avant-garde designs if it wants to upgrade and progress. No matter how many functions these new designs have, it is a brave attempt and exploration.

Other details of the design include the double trunk design and small blind spotsAColumn design and so on. BoyueLAs Geely Automobile LayoutAlevelSUVThe heavyweight products in the market have high hopes from Geely Automobile. It is reported that the new car is also standardL2Advanced driver assistance systems,540° Looking around at panoramic images and other functional configurations, I think users don’t have to worry about the overall strength. With more and more information disclosure, BoyueLThe IPO time will not be too far, I think users may pay more attention to the price of this car, if the price is more "close to the people", BoyueLIt is very promising to becomeAThe new "dark horse" model in the first-class market. Everyone thinks BoyueLHow is your strength? Welcome to discuss in the comment section.

I am the wood teacher, I hope you buy a car less detours.

A reliable interpretation of zhenai’s marriage matchmaker： co-production of love The Secret Behind, soul fit is the key.

With the progress of society and the change of ideas, more and more people begin to choose blind date to find their other half. In this fast-paced era, zhenai blind date platform has become the first choice for many single young people. For blind date, many people have a common expectation, that is, to find a partner who fits their soul. In this process, the professional interpretation of zhenai matchmaker played a vital role.

What is soul fit? Soul fit not only refers to the attraction of two people in appearance or the coincidence of interests and hobbies, but more importantly, the two sides have a high degree of fit in emotion, values and ways of thinking. This fit makes it easier for both sides to understand and trust each other, thus establishing a deep emotional connection.

Zhenai matchmaker plays an important role in blind date in zhenai. Through professional interpretation and analysis, they help single young people find a partner who fits their soul more accurately. They will give the most appropriate suggestions and recommendations by analyzing the personality characteristics, living habits and hobbies of both parties.

At the same time, zhenai blind date platform also improves the success rate through systematic matching algorithm. This algorithm will recommend the most suitable potential partner for members according to their personal information, mate selection requirements and other reference factors. In this way, zhenai provides more opportunities for single young people to find suitable partners.

So, is zhenai reliable? According to statistics, zhenai has helped thousands of single young people find suitable partners successfully. This also proves the reliability and credibility of the blind date platform in zhenai. Through professional service and strict audit, zhenai ensures the authenticity and safety of every member.

In the process of zhenai’s marriage, the change of ideas is also an important factor. In the past, many people paid more attention to appearance and external conditions in blind date, but ignored the fit of soul. Now, more and more people begin to attach importance to the harmony of souls. They hope to find a partner who can understand and support each other and walk through every stage of life together.

The existence and development of blind date platform in zhenai provides more choices and opportunities for single young people to find suitable partners. Through blind date, they can get to know each other more comprehensively and communicate in an open environment. Such communication and getting along with each other will lay a good foundation for them and lead them to a happy married life.

In a word, the love in tune is inseparable from the deep fit of the soul. In the process of blind date in zhenai, soul fit has become the most important consideration. Through the professional interpretation of zhenai matchmaker and the matching algorithm of blind date platform, single young people can find their soul-compatible partners more accurately. The reliability and credibility of the blind date platform in zhenai have been recognized by the majority of single young people. Let’s embrace the changes of this era, believe in the power of zhenai, find a suitable partner and move towards a happy life.

Reporting/feedback

Understanding China’s ＂Harmony＂ Culture

Source: People’s Daily Online-People’s Daily Overseas Edition

The audience enjoyed the "Zhonghe Shaole" musical instrument in Qing Dynasty. Du Jianpo

Qing gan long Jin tai enamel figure holding pot Du Jianpo

Qing gan long Ji Qing Jin Cai hai Yan he Qing Zun Photo courtesy of Guobo

Qing Qianlong’s "seventy-two poems on the imperial month" is colored ink (September and October). Du Jianpo

From ancient stone tools, bone implements, jade articles and pottery to colorful export porcelain and finely carved lacquerware, from the silk painting "Fuxi Nu Wa Tu" drawn by the Tang Dynasty to the Tao Te Ching written by the calligrapher in fine small letters in the Yuan Dynasty … into the China National Museum "Harmony and Symbiosis-the Forbidden City-Guobo Tibetan Cultural Relics Joint Exhibition", rich cultural relics show the long history of Chinese civilization.

This exhibition is the first heavy special exhibition jointly launched by the Palace Museum and the National Museum of China. More than 400 cultural relics are selected from the rich collections of the Palace Museum and Guobo for display. The exhibition is divided into four units, which expounds the historical origin and rich connotation of China’s "harmony" culture from four aspects: the universe, the world, society and morality. The first unit, "Harmony between Heaven and Earth", explains the cosmology of the unity of heaven and man advocated by the Chinese nation since ancient times; The second unit, "Harmony among All Nations", explains the world view of harmony among all nations upheld by the Chinese nation when dealing with foreign relations; The third unit, "Yi Min An He", explains Chinese civilization’s respect and tolerance for the cultural diversity of all social strata and ethnic groups. The fourth unit, "Happiness lies in harmony with people", explains the moral concept of "people’s hearts are kind" of the Chinese nation.

Wisdom of the Unity of Heaven and Man

Stepping into the exhibition hall, the jade ritual vessels of Hongshan culture Yulong, Liangzhu culture Jade Cong and Qijia culture Jade Bi attracted the audience to stop and enjoy. Chinese ancestors collected natural jade and carefully crafted it into a ritual vessel to communicate with heaven and earth and offer sacrifices to ancestors. Today, thousands of years later, when we see these jade articles, we will still be amazed by the superb carving skills and rich imagination of our ancestors.

From chiseling stone, grinding bone and reeling silk to making pottery, smelting copper and painting lacquer, the ancients had a deeper and more comprehensive understanding of the development and utilization of natural materials and the laws of nature, and the emotional resonance and aesthetic concepts caused by natural phenomena were gradually integrated into labor practice and material creation, thus forming a unique ritual and music civilization and social system of the Chinese nation.

In ancient times, the ancestors in the middle and lower reaches of the Yellow River summed up the laws of natural changes according to the climate and four seasons alternately, so as to guide daily life and realize the progress of productive forces. Monthly order, that is, taking the four seasons as the general outline and December as the details, records the astronomical calendar and natural phenology in time, and arranges the decrees of production and life accordingly. In the exhibition hall, Qingganlong’s "Poems of seventy-two waiting for the moon" is the embodiment of the cultural tradition of "obeying the weather and responding to the times". This ink set consists of two boxes, with 6 drawers in each box and 6 spindles in each drawer, totaling 72 spindles. One spindle of ink corresponds to a phenology, with different sizes and shapes, including round, oval, square, hexagonal, leaf, tablet, harp and bell. Ink colors are divided into green, red, white, blue and yellow, which correspond to the traditional five elements in China: spring (first month and February) is wood, which corresponds to green; Summer (April and May) is fire, corresponding to red; Autumn (July and August) is gold, corresponding to white; Winter (October and November) is water, corresponding to blue; The turn of the two seasons (March, June, September and December) is earth, which means activation and hair growth, corresponding to yellow.

Next to the moon-colored ink, there is a set of poems cups with colorful December flowers in Qing Kangxi. This set of multicolored cups consists of 12 pieces. The bright white glaze is decorated with blue and white multicolored flowers. On the one hand, the representative flowers of each month are painted, and on the other hand, the poems corresponding to the flowers are inscribed. Most of the poems are taken from The Whole Tang Poetry. This set of porcelain cups belongs to the imperial wine glasses, with thin and light tires, beautiful patterns and neat styles, which represents the highest level of making blue and white multicolored thin-shell porcelain in Jingdezhen Imperial Kiln Factory in Kangxi Dynasty.

On the one hand, there are bronze bells, chimes and cymbals in the Spring and Autumn Period and the Warring States Period, and on the other hand, there is the glittering "Zhonghe Shaole" musical instrument in the Qing Dynasty. The two sets of exhibits reflect the inheritance and development of Chinese ritual and music culture for thousands of years. Elegant music is the orthodox music used in ancient China to worship heaven and earth, ancestors, and banquets. Its system was formulated in the early years of the Western Zhou Dynasty. The main musical instruments of ancient elegant music are chimes and chimes. The music begins with a bronze bell and ends with a jade chime, which is a combination of many voices and symbolizes "golden sound and jade vibration". "Zhonghe Shaole" has the highest specification in the music system of Ming and Qing Dynasties, and is mainly used for altar and temple sacrifices and national ceremonies above Zhongsi. The bronze-gilded chime with double dragons and dragons’ buttons and dragons’ patterns made during the reign of Emperor Qianlong of Qing Dynasty was hung on the shelf carved with dragons and painted with gold in two layers, showing its dignity and elegance. Matching with it, the jadeite-painted plait with Un-yong Kim pattern is made of precious jade from Hetian, Xinjiang, and both sides of the chime are decorated with Un-yong Kim pattern. The golden yellow of the gold-painted pattern and the emerald green of the jade are brilliant.

Openness and tolerance

In the independent showcase, a small seal on one side evokes people’s reverie of desert wind and smoke and camel bells. This lute was unearthed from Zhang Qian’s tomb in Chenggu County, Shaanxi Province, and the front is engraved with the words "Bowang-Zao" in Yang. During the period of Emperor Wu of the Han Dynasty, Zhang Qian was ordered to make two missions to the Western Regions, which opened up the world-famous Silk Road and was named Bo Wanghou.

The brocade of the Tang Dynasty with decorative group patterns, knight patterns and pig head patterns tells the story of increasing prosperity after the Silk Road was opened for thousands of years. The exotic patterns are integrated with the traditional auspicious patterns in the Central Plains, presenting an open, inclusive and colorful prosperous scene.

Painted porcelain from Changsha kiln in the Tang Dynasty, celadon from Longquan kiln in the Yuan Dynasty, blue-and-white porcelain from Jingdezhen kiln in the Ming Dynasty, and wide-colored porcelain in the Qing Dynasty … Famous export porcelain products of past dynasties witnessed the prosperity of the Maritime Silk Road. A green glazed phoenix tail statue of Longquan kiln with elegant shape and exquisite decoration attracted the reporter’s attention. This statue has a long neck, rich shoulders, and gradually converges below the abdomen, slightly skimming near the foot and circling the foot. Thick blue glaze is applied inside and outside the porcelain, and the glaze is open. The neck is carved with dense chords, the upper abdomen is carved with branches-bound peony, and the lower abdomen is carved with chrysanthemum petals. According to reports, in a Yuan Dynasty shipwreck full of ceramics in Xin ‘an sea area, South Korea, a phoenix-tailed statue with green glaze and peony pattern in Longquan kiln was found, which proved that Longquan kiln celadon played an important role in the cultural exchange and trade of the Maritime Silk Road in Yuan Dynasty.

Corresponding to these export porcelains, overseas countries learn from China’s porcelain-making technology to produce porcelains. For example, Koryo celadon in the 12th century, Jingdezhen multicolored porcelain imitated by Maisen kiln in Europe in the 18th century, and Dehua kiln white porcelain imitated by Japan in the 19th century. These foreign porcelain products have flowed into China and entered the palace, which has become a much-told story for the exchange and mutual learning between Chinese and foreign civilizations.

Passing through a porch that imitates the panorama of the Forbidden City, a series of exhibits come into view, which reflect the achievements of innovation and development after the introduction of western culture into China. The figurines of the Qing-Gan-Long Golden Fetus Enamel are combined with many techniques such as inlay, engraving, silk-twisting enamel and painting enamel, which are exquisite and amazing. This pot is made of gold, and its shape is gourd-shaped. The whole body is painted with blue enamel, decorated with twisted silk and lotus patterns, and inlaid with pearls and corals in many places. Painted enamels with different sizes and shapes are symmetrically arranged on the lid, neck, lower abdomen and large abdomen, and figures, flowers and courtyard landscapes are painted inside the enamel. Under it, it is equipped with a lotus-carved gold-plated copper seat. Cloisoned enamel and painted enamel are all imported from the west. During Qianlong period, there were few figures decorated in enamel products, so this device can be called a masterpiece. The ladies and courtyard figures painted in the opening of the vessel are traditional paintings in China, but they are expressed by European techniques, which reflects the artistic style of combining Chinese and Western styles.

The morality of harmony and goodness

The third unit of the exhibition presents a picture of the harmonious coexistence of scholars, agriculture, industry and commerce in ancient China. "Han Bao Sai Wu Huan leads many leaders" camel button bronze seal is the official seal awarded by the Eastern Han Dynasty court to the leaders of Wu Huan nationality. Wuhuan is a branch of Donghu people in ancient China. The title of "leading the crowd" is related to his deeds such as leading the crowd to join, guarding the frontier fortress, helping the war and counterinsurgency. Cultural relics with national characteristics, such as the bronze musical instruments of southwest nationalities in Han Dynasty, the jade carvings of "Spring Water" and "Autumn Mountain" in Jin Dynasty, and the "Gong Gong Tu" in Ming and Qing Dynasties, reflect the colorful national culture.

The Southern Tour of Qianlong is a huge historical picture of Qing Dynasty painter Xu Yang’s first southern tour of Jiangsu and Zhejiang in 1751 with "imperial poetry as the picture". The whole picture consists of 12 volumes, which combines poetry, calligraphy and painting, and realistically depicts the scene of Qianlong’s early trip to the south of the Yangtze River, the province asking for customs, inspecting officials and the people, inspecting river workers, reviewing divisions and brigades, offering sacrifices to Yuling and visiting scenic spots in lakes and mountains, which truly reflects the splendid rivers and mountains and social features. In this exhibition, the sixth volume of the Southern Tour of Qianlong was exhibited. This volume is entitled "Zhu Gu Su", which focuses on the landscape from Changmen to Xumen in Suzhou. The whole painting takes the Grand Canal as the main axis, with houses and shops along the banks of the river, which is full of prosperity and prosperity.

The foundation of a harmonious society is the values of "people are kind" and "harmony is the most important". Ming Xianzong Zhu Jianshen painted the axis of "A Harmony Map", depicting three old people huddled together, with the old man on the left wearing a Taoist crown, the old man in the middle dressed as a monk, and a Confucian scholar wearing a square towel on the right. The composition of the whole work is ingenious, and it looks like a smiling Maitreya sitting cross-legged, beaming and harmonious, showing the thought of the unity and harmonious blending of Confucianism, Buddhism and Taoism.

At the end of the exhibition, a piece of green and golden colors, Haiyan River, attracted people’s attention. The outer wall of this device is painted with blue enamel, with gold-painted branches-bound peony, banana leaf pattern, ruyi cloud pattern, etc., and near the foot is decorated with pastel lotus pattern and lotus bead pattern, and a pair of white swallows with wings spread and tails cut are carved between the shoulders and necks as ears. This porcelain statue was fired by Jingdezhen Imperial Kiln in the Qing Dynasty for Haiyan Hall in Yuanmingyuan. It needs to be put into the kiln and painted many times, and its technology is superb, which is a combination of carving, pasting and embossing. The blue color of this statue symbolizes "Heqing", and Yan is homophonic with "Yan", which means that Haiyan River is clear and the world is peaceful.

Romano： Rafinha said he intends to stay in Barcelona.

According to transfer expert Romano, although there are many clubs interested in Rafinha, he said he would stay in Barcelona.

Previous reports pointed out that if Barcelona receives a transfer fee of 80 million euros, then Brazilians may be sent away because the club is working withFiscal equity policyFight.

Rafinha put an end to these rumours, and the former Leeds United winger hopes to stay at the club in the future.

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